304896-21-7
304896-21-7 structure
- Name: AGK7
- Chemical Name: 2-cyano-3-[5-(2,5-dichlorophenyl)furan-2-yl]-N-quinolin-8-ylprop-2-enamide
- CAS Number: 304896-21-7
- Molecular Formula: C23H13Cl2N3O2
- Molecular Weight: 434.274
- Create Date: 2018-06-21 01:25:34
- Modify Date: 2025-08-25 13:12:00
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AGK7 is a potent inhibitor of sirtuin 2 (SIRT2). AGK7 rescues alpha-synuclein toxicity and modified inclusion morphology in a cellular model of Parkinson's disease. AGK7 protects against dopaminergic cell death both in vitro and in a Drosophila model of Parkinson's disease[1].
| Name | 2-cyano-3-[5-(2,5-dichlorophenyl)furan-2-yl]-N-quinolin-8-ylprop-2-enamide |
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| Synonyms |
(2E)-2-Cyano-3-[5-(2,5-dichlorophenyl)-2-furyl]-N-(8-quinolinyl)acrylamide
2-Propenamide, 2-cyano-3-[5-(2,5-dichlorophenyl)-2-furanyl]-N-8-quinolinyl-, (2E)- (2E)-2-cyano-3-[5-(2,5-dichlorophenyl)furan-2-yl]-N-(quinolin-8-yl)prop-2-enamide (2E)-2-Cyano-3-[5-(2,5-dichlorophenyl)-2-furyl]-N-(quinolin-8-yl)acrylamide SIRT2 Inhibitor,Inactive Control,AGK7 |
| Description | AGK7 is a potent inhibitor of sirtuin 2 (SIRT2). AGK7 rescues alpha-synuclein toxicity and modified inclusion morphology in a cellular model of Parkinson's disease. AGK7 protects against dopaminergic cell death both in vitro and in a Drosophila model of Parkinson's disease[1]. |
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| Related Catalog | |
| References |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 675.1±55.0 °C at 760 mmHg |
| Molecular Formula | C23H13Cl2N3O2 |
| Molecular Weight | 434.274 |
| Flash Point | 362.1±31.5 °C |
| Exact Mass | 433.038483 |
| PSA | 82.41000 |
| LogP | 6.77 |
| Vapour Pressure | 0.0±2.1 mmHg at 25°C |
| Index of Refraction | 1.718 |