1027330-82-0

1027330-82-0 structure

Name: A-940894
Chemical Name: 4-piperazin-1-yl-6,7-dihydro-5H-benzo[1,2]cyclohepta[3,4-b]pyrimidin-2-amine
CAS Number: 1027330-82-0
Molecular Formula: C₁₇H₂₁N₅
Molecular Weight: 295.38200
Catalog: Signaling Pathways GPCR/G Protein Histamine Receptor
Create Date: 2017-09-29 03:55:08
Modify Date: 2024-02-08 20:59:50
A-940894 is a potent histamine H4 receptor antagonist, with Ki values of 7.6 nM (rat H4) and 71 nM (human H4). A-940894 exhibits with anti-inflammatory properties[1].

Name	4-piperazin-1-yl-6,7-dihydro-5H-benzo[1,2]cyclohepta[3,4-b]pyrimidin-2-amine
Synonyms	2,4-diamino-5,6-disubstituted pyrimidine,9 UNII-8U5620H545

Description	A-940894 is a potent histamine H4 receptor antagonist, with Ki values of 7.6 nM (rat H4) and 71 nM (human H4). A-940894 exhibits with anti-inflammatory properties[1].
Related Catalog	Signaling Pathways >> Immunology/Inflammation >> Histamine Receptor Research Areas >> Inflammation/Immunology Signaling Pathways >> GPCR/G Protein >> Histamine Receptor
Target	Ki: 7.6 nM (rat H4), 71 nM (human H4)[1].
References	[1]. M I Strakhova, et al. In vitro and in vivo characterization of A-940894: a potent histamine H4 receptor antagonist with anti-inflammatory properties. Br J Pharmacol. 2009 May;157(1):44-54.