Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Trichostatin A S-isomer
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DC Chemicals Limited
China
Product Name: Trichostatin A S-isomer
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Purity: 98.0%
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ShangHai DC Chemicals Co.,Ltd
China
Product Name: Trichostatin A S-isomer
Price: ￥Inquiry/1g
Purity: 98.9%
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122292-85-7

122292-85-7 structure

122292-85-7 structure

Name: Trichostatin A S-isomer
Chemical Name: Trichostatin A
CAS Number: 122292-85-7
Molecular Formula: C₁₇H₂₂N₂O₃
Molecular Weight: 302.36800
Catalog: Signaling Pathways Cell Cycle/DNA Damage HDAC
Create Date: 2016-02-14 06:38:39
Modify Date: 2025-08-25 18:06:36

Name	Trichostatin A
Synonyms	.TSA .(R)-trichostatin A .(R)-(+)-trichostatin A .(7-[4-(dimethylamino)phenyl]-N-hydroxy-4,6-dimethyl-7-oxohepta-2,4-dienamide) (+)-TSA

Description	(S)-Trichostatin A ((S)-TSA) 是一种 HDAC6 选择性抑制剂，对斑马鱼 HDAC6 和人 HDAC6 的 IC50 值分别为 9.88 nM和 11.1 nM。(S)-Trichostatin A 弱抑制其他人 HDAC。
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> HDAC Signaling Pathways >> Epigenetics >> HDAC
Target	hHDAC6:11.1 nM (IC50) Zebrafish HDAC6:9.88 nM (IC50) hHDAC1:206.3 nM (IC50) hHDAC2:612.65 nM (IC50) hHDAC3:320.8 nM (IC50) hHDAC4:6341 nM (IC50) hHDAC5:6325 nM (IC50) hHDAC7:1823.5 nM (IC50) hHDAC8:312.2 nM (IC50) hHDAC9:4824 nM (IC50) hHDAC10:403.35 nM (IC50) hHDAC11:2684 nM (IC50)
References	[1]. Yasuyuki Miyake, et al. Structural insights into HDAC6 tubulin deacetylation and its selective inhibition. Nat Chem Biol. 2016 Sep;12(9):748-54.

Molecular Formula	C₁₇H₂₂N₂O₃
Molecular Weight	302.36800
Exact Mass	302.16300
PSA	69.64000
LogP	2.97020

114127-18-3 structure

114127-18-3

~%

122292-85-7 structure

122292-85-7

Literature: Mori, Kenji; Koseki, Koshi Tetrahedron, 1988 , vol. 44, # 19 p. 6013 - 6020

122222-78-0 structure

122222-78-0

~%

122292-85-7 structure

122292-85-7

Literature: Mori, Kenji; Koseki, Koshi Tetrahedron, 1988 , vol. 44, # 19 p. 6013 - 6020

Precursor 2
114127-18-3 122222-78-0
DownStream 0

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