Trichostatin A S-isomer

Modify Date: 2025-08-25 18:06:36

Trichostatin A S-isomer Structure
Trichostatin A S-isomer structure
 Common Name Trichostatin A S-isomer
CAS Number 122292-85-7 Molecular Weight 302.36800
Density N/A Boiling Point N/A
Molecular Formula C17H22N2O3 Melting Point N/A
MSDS N/A Flash Point N/A

 Names

Name Trichostatin A
Synonym More Synonyms

 Trichostatin A S-isomer Biological Activity

Description (S)-Trichostatin A ((S)-TSA) 是一种 HDAC6 选择性抑制剂，对斑马鱼 HDAC6 和人 HDAC6 的 IC50 值分别为 9.88 nM和 11.1 nM。(S)-Trichostatin A 弱抑制其他人 HDAC。
Related Catalog
Target

hHDAC6:11.1 nM (IC50)

Zebrafish HDAC6:9.88 nM (IC50)

hHDAC1:206.3 nM (IC50)

hHDAC2:612.65 nM (IC50)

hHDAC3:320.8 nM (IC50)

hHDAC4:6341 nM (IC50)

hHDAC5:6325 nM (IC50)

hHDAC7:1823.5 nM (IC50)

hHDAC8:312.2 nM (IC50)

hHDAC9:4824 nM (IC50)

hHDAC10:403.35 nM (IC50)

hHDAC11:2684 nM (IC50)

References

[1]. Yasuyuki Miyake, et al. Structural insights into HDAC6 tubulin deacetylation and its selective inhibition. Nat Chem Biol. 2016 Sep;12(9):748-54.  

 Chemical & Physical Properties

Molecular Formula C17H22N2O3
Molecular Weight 302.36800
Exact Mass 302.16300
PSA 69.64000
LogP 2.97020

 Precursor & DownStream

Precursor  2

DownStream  0

 Synonyms

.TSA
.(R)-trichostatin A
.(R)-(+)-trichostatin A
.(7-[4-(dimethylamino)phenyl]-N-hydroxy-4,6-dimethyl-7-oxohepta-2,4-dienamide)
(+)-TSA
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Related Compounds: More...
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(4R)-5-[2-[3-[[(2R)-4-[[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxy-2-hydroxy-3,3-dimethylbutanoyl]amino]propanoylamino]ethylsulfanyl]-4-hydroxy-5-oxopentanoic acid
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[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [(3R)-4-[[3-(2-dimethylarsanylsulfanylethylamino)-3-oxopropyl]amino]-3-hydroxy-2,2-dimethyl-4-oxobutyl] hydrogen phosphate
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Exiguaflavanone A
142608-98-8
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Coenzyme A, S-(2-carboxy-γ-oxobenzenebutanoate)
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Coenzyme A, S-(15Z)-15-tetracosenoate
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trifarienol A
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Ethyl 3-chloro-4-hydroxyphenylacetate
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2-[(2,6-Dichlorophenyl)amino]benzeneacetyl chloride
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4-Chloro-1-(2-methylpropyl)-1H-imidazo[4,5-c]quinoline-2-methanol benzoate ester
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benzyl N-[(2R)-2-hydroxy-2-(4-methoxyphenyl)ethyl]carbamate
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4-(1-Ethylhexyl)-2,6-dinitrophenyl butenoate
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4-(1-Propylpentyl)-2,6-dinitrophenyl butenoate
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2-(1-Ethylhexyl)-4,6-dinitrophenyl butenoate
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