Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Secalciferol
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
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55721-11-4

55721-11-4 structure

Name: Secalciferol
Chemical Name: (24R)-24,25-dihydroxycalciol
CAS Number: 55721-11-4
Molecular Formula: C₂₇H₄₄O₃
Molecular Weight: 416.637
Catalog: Signaling Pathways Vitamin D Related VD/VDR
Create Date: 2018-06-01 08:00:00
Modify Date: 2026-07-01 17:29:21
Secalciferol is a metabolite of Vitamin D, a possibly anti-inflammatory steroid which is involved in bone ossification. IC50 value:Target: In addition, it is known that Secalciferol mediates calcium and phosphorus homeostasis. Also Secalciferol inhibits calcium channels in osteosarcoma cells via suppressing the effects of 1α, 25-dihydroxyvitamin D3 and testosterone. Alternate studies indicate that Secalciferol can decrease the abundance of p53 and Pi-induced cytochrome c translocation. Furthermore, Secalciferol can increase cell proliferation in resting zone (RC) chondrocytes and inhibits matrix enzymes by possibly inhibiting the degradation of the matrix.

Name	(24R)-24,25-dihydroxycalciol
Synonyms	(24r)-hydroxycalcidiol k-dr 24R,25-Dihydroxyvitamin D3 (Solution) Flk Secalciferol, 24R,25-dihydroxycholecalciferol, 24R,25-dihydroxyvitamin D3, 24R 25 DHCC vasculendothelial owth factor rector 2 D3/(24R)-24,25-dihydroxycalciol VGFR2 Secalciferol/ 24R, 25-Dihydroxycholecalciferol (24R)-24,25-Dihydroxyvitamin D3 Stilbitol 24(r),25-dihydroxycholecalciferol ANTI-VEGFR2 (FLK1/KDR)(C-TERMINAL) antibody produced in rabbit Human KDR/VEGFR2 Protein, His & GST Tag Anti-VEGFR2, C-Terminal antibody produced in rabbit 24R,25-Dihydroxyvitamin D3-[d6] kinase insert domain rector Human KDR/VEGFR2 Protein, His Tag ANTI-VGFR2 antibody produced in rabbit osteod Recombinant Human CD309/KDR Protein, His Tag Secalciferol [(24R)-24,25-Dihydroxyvitamin D3 (3S,5Z,7E,14β,24R)-9,10-Secocholesta-5,7,10-triene-3,24,25-triol 24R.25-Dihydroxyvitamin D3-[-d6] in Ethanol Recombinant Human CD309/VEGFR2/KDR Protein, His tag (3R,6R)-6-[(1R,3,4E,7-4-[(2Z)-2-[(5S)-5-hydroxy-2-methylidene-cyclohexylidene]ethylidene]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-1-yl]-2-methyl-htane-2,3-diol 24R.25-Dihydroxyvitamin D3-[13C5] in Ethanol 2,3-Htanediol, 2-methyl-6-[(1R,3aS,4E,7-octahydro-4-[(2Z)-2-[(5S)-5-hydroxy-2-methylenecyclohexylidene]ethylidene]-7a-methyl-1H-inden-1-yl]-, (3R,6R) Human KDR/VEGFR2 Protein, Fc Tag (24R)-24,25-Dihydroxycholecalciferol 7,10-triene-3,24,25-triol,(3-beta,5z,7e,24r)-10-secocholesta-5 CD309 (24R)-24 (3-beta,5z,7e,24r)-9,10-secocholesta-5,7,10-triene-3,24,25-triol protein-tyrosine kinase rector Flk-1 ro21-5816 24R.25-Dihydroxyvitamin D3 in Ethanol

Description	Secalciferol is a metabolite of Vitamin D, a possibly anti-inflammatory steroid which is involved in bone ossification. IC50 value:Target: In addition, it is known that Secalciferol mediates calcium and phosphorus homeostasis. Also Secalciferol inhibits calcium channels in osteosarcoma cells via suppressing the effects of 1α, 25-dihydroxyvitamin D3 and testosterone. Alternate studies indicate that Secalciferol can decrease the abundance of p53 and Pi-induced cytochrome c translocation. Furthermore, Secalciferol can increase cell proliferation in resting zone (RC) chondrocytes and inhibits matrix enzymes by possibly inhibiting the degradation of the matrix.
Related Catalog	Signaling Pathways >> Vitamin D Related >> VD/VDR Research Areas >> Inflammation/Immunology
References	[1]. Yamamoto T, Ozono K, Shima M, et al. 24R,25-dihydroxyvitamin D3 increases cyclic GMP contents, leading to an enhancement of osteocalcin synthesis by 1,25-dihydroxyvitamin D3 in cultured human osteoblastic cells. Exp Cell Res. 1998 Oct 10;244(1):71-6. [2]. Sakaki T, Sawada N, Takeyama K, et al. Enzymatic properties of mouse 25-hydroxyvitamin D3 1 α-hydroxylase expressed in Escherichia coli. Eur J Biochem. 1999 Feb;259(3):731-8. [3]. Norman AW, Okamura WH, Bishop JE, Henry HL. Update on biological actions of 1α,25(OH)2-vitamin D3 (rapid effects) and 24R,25(OH)2-vitamin D3. Mol Cell Endocrinol. 2002 Nov 29;197(1-2):1-13 [4]. Hurst-Kennedy J, Zhong M, Gupta V et al. 24R,25-Dihydroxyvitamin D3, lysophosphatidic acid, and p53: a signaling axis in the inhibition of phosphate-induced chondrocyte apoptosis. J Steroid Biochem Mol Biol. 2010 Oct;122(4):264-71. [5]. Wehmeier KR, Alamir AR, Sultan S, et al. 24, 25-dihydroxycholecalciferol but not 25-hydroxycholecalciferol suppresses apolipoprotein A-I gene expression. Life Sci. 2011 Jan 3;88(1-2):110-6. [6]. Rubin LP, Yeung B, Vouros P et al. Evidence for human placental synthesis of 24,25-dihydroxyvitamin D3 and 23,25-dihydroxyvitamin D3. Pediatr Res. 1993 Jul;34(1):98-104.

Density	1.1±0.1 g/cm3
Boiling Point	571.1±35.0 °C at 760 mmHg
Melting Point	63-65ºC
Molecular Formula	C₂₇H₄₄O₃
Molecular Weight	416.637
Flash Point	241.5±20.5 °C
Exact Mass	416.329041
PSA	60.69000
LogP	5.85
Vapour Pressure	0.0±3.6 mmHg at 25°C
Index of Refraction	1.547
Storage condition	2-8℃

CHEMICAL IDENTIFICATION

RTECS NUMBER :: VS2895000

CHEMICAL NAME :: 9,10-Secocholesta-5,7,10(19)-triene-3,24,25-triol, (3-beta,5Z,7E,24R)-

CAS REGISTRY NUMBER :: 55721-11-4

LAST UPDATED :: 199512

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C27-H44-O3

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >10 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JKXXAF Japanese Kokai Tokyo Koho Patents. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Volume(issue)/page/year: #94-247858

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >2 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JKXXAF Japanese Kokai Tokyo Koho Patents. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Volume(issue)/page/year: #94-247858

Symbol	GHS06, GHS08
Signal Word	Danger
Hazard Statements	H301 + H311-H330-H372
Precautionary Statements	P260-P280-P284-P301 + P310-P310
Personal Protective Equipment	Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
Hazard Codes	T+:Verytoxic;
Risk Phrases	R28
Safety Phrases	S28-S36/37-S45
RIDADR	UN 2811
RTECS	VS2895000

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