867-44-7
867-44-7 structure
- Name: S-Methylisothiourea sulfate
- Chemical Name: 2-Methyl-2-thiopseudourea sulfate
- CAS Number: 867-44-7
- Molecular Formula: C2H8N2O4S2
- Molecular Weight: 188.226
- Catalog: Organic raw materials Organic sulfur compound
- Create Date: 2018-10-04 21:10:24
- Modify Date: 2026-07-01 17:02:10
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S-Methylisothiourea sulfate is a potent, selective and competitive inhibitor of inducible nitric oxide synthase (iNOS). S-Methylisothiourea sulfate exerts beneficial effects in rodent models of septic shock[1].
| Name | 2-Methyl-2-thiopseudourea sulfate |
|---|---|
| Synonyms |
S-Methyl-isothiouronium Hemisulfate
S-METHYLTHIOPSEUDOUREA SULPHATE CbaMiMidothioic acid Methyl ester,sulphate salt forM 2-Methyl-2-thiopseudourea hemisulfate cbamimidothioicacid,methylester,sulfate(2:1) S-METHYLISOTHIOHARNSTOFF HEMISULFAT 2-Methyl-2-thiopseudourea hemisulfate hemihydrate S-methylisothiourea sulfuric acid salt 1:1 2-METHYL-2-THIOSEUDOUREA SULFATE S-Methylisothiouroniumsulfate Methyl cbaMiMidothioate bis(sulfate) S-METHYLTHIOURONIUM SULFATE FOR SYNTHESI S-EIT hemihydrate 2-methyl-2-thiopseudouronium sulfate S-METHYLISOTHIOURONIUM SULPHATE Bis(2-methylisothiouronium) sulphate (2-6) 2-methyl-2-thiopseudourea sulfate S-Methylthioureasulfat Bis(S-methyl isothiourea) sulfate s-Methylthiuronium sulphate 2-Methyl-2-thiopseudourea sulphate methylsulfanylmethanimidamide S-Methylisothiourea sulfate(2:1)or(2-methyl-2-thiopseudourea sulfate) S-Methyl isothiourea sulfate 2-METHYL-ISOTHIOUREA 2-Methyl-2-thiopseudoureasulfate s-methylthiouroniumsulfate(2:1) S-METHYL-ISO-THIOUREA SULFATE S-Methylisothiourea Hemisulfate Salt S-METHYLISOTHIOURONIUM SULPHATE/S-METHYLISOTHIOUREA SULPHATE/2-METHYL-2-THIOPSEUDOUREA SULPHATE 2-METHYL-2-THIOPSEUDOUREA SULFATE (S-METHYLISOTHIOUREA SULFATE) MFCD00129752 2-Methyl-2-thiopseudourea heMisulfate, R S-MethylisothioureaSulfate> Bis(2-methylthiouronium) sulphate methylcbamimidothioate sulfate methyl imidothiocarbamate S-Methylisothiourea heMisulfate salt 2-Methyl-2-thiopseudourea sulfate ISO 9001：2015 REACH S-METHYL ISOTHIOUREA SULFATE Carbamimidothioic acid, methyl ester, sulfate (2:1) S-methyl-2-thiopseudourea hydrogen sulfate S-METHYLTHIOURONIUM SULFATE S-Methylthioureasulfate=2-Methyl-2-thiopseudoureasulfate s-methylisothioureasulfate(2:1) 2-Methyl-2-thiopseudourea hemisulfate salt, S-Methyl-ITU, S-Methylthiuronium sulfate, SMT 2-Methyl-2-Thiopseudourea S-methylisothiourea hydrogensulfate S-Methyl-ITU S-MethyliSothourea Sulfate Methyl cbamimidothioate hemisulphate methyl imidothiocarbamate sulfate 2-Methyl-2-thiopseud EINECS 212-759-7 S-methyl isothiourea sultate Methyl isothiourea disulfate 2-METHYL-2-THIOPSEUDO UREA 14C SULFATE 2-methyl-2-thio-pseudouresulfate(2:1) 2-methylisothiourea sulfuric acid S-METHYL-ISO-THIOUREA S-methyl Isothiourea (hemisulfate) [amino-(methylthio)methylidene]ammonium S-METHYLISOTHIOURONIUM SULFATE S-Methylthiouronium sulfate S-METHYLISOTHIOUREA HEMISULFATE NITRIC O XIDE SYNTHASE 5-METHYLISOTHIOUREA HEMISULFATE Carbamimidothioic acid, methyl ester, sulfate (1:1) (S)-METHYLISOTHIOUREA SULFATE METHYLTHIOURONIUMSULPHATE Methyl imidothiocbamate sulfate Methyl carbamimidothioate sulfate (1:1) methylcbamimidothioatesulfate(2:1) S-METHYLTHIOUREA S-METHYL-2-ISOTHIOUREA HEMISULPHATE 5-METHYLISOTHIOUREAHEMISULFATE isothiouronium suL S-methylisothiouronium hydrogensulfate methyl carbamimidothioate S-METHYLISOTHIOUREASULFATE Methylisothioureahydrogensulfate S-METHYLTHIOURONIUM SULFATE FOR SYNTHESIS S-Methylisothiourea hemisulfate S-METHYLISOTHIOUREA HEMISULFATE SALT _X000D_ S-MethylisothiouroniuM sulfate 2-methyl-2-thio-pseudoure sulfate IMINO(METHYLSULFANYL)METHYLAMINE Amino(methylsulfanyl)methaniminium hydrogen sulfate (1:1:1) S-Methyl-ITU . sulfate S-METHYLTHIOURONIUMSULFATE(2:1) S-Methyl-2-isothiourea hemisulphate METHYLTHIURONIUMSULPHATE S-Methyl-isothiouroniuM HeMisulfate |
| Description | S-Methylisothiourea sulfate is a potent, selective and competitive inhibitor of inducible nitric oxide synthase (iNOS). S-Methylisothiourea sulfate exerts beneficial effects in rodent models of septic shock[1]. |
|---|---|
| Related Catalog | |
| Target |
iNOS[1] |
| In Vitro | S-Methylisothiourea sulfate is a competitive inhibitor of iNOS activity at the L-arginine site[1]. S-Methylisothiourea sulfate prevents the NO-mediated cytotoxic effect of LPS in cultured macrophages[1]. S-Methylisothiourea sulfate (100 nM-100 μM) exhibits inhibitory effects on LPS (ug/mL)-induced nitrite production in J774.2 macrophages and rat aortic vascular smooth muscle cells[1]. S-Methylisothiourea sulfate(up to 1 mM) does not inhibit the activity of xanthine oxidase, diaphorase, lactate dehydrogenase, monoamine oxidase, catalase, cytochrome P450, or superoxide dismutase[1]. |
| In Vivo | S-Methylisothiourea sulfate (0.01-3 mg/kg; i.v.) dose-dependently reverses the hypotension and the vascular hyporeactivity to vasoconstrictor agents caused by endotoxin LPS in anesthetized rats[1]. S-Methylisothiourea sulfate (5 mg/kg; i.p.; given 2 hr after LPS; 10 mg/kg, i.p.) attenuates the rises in plasma alanine and aspartate aminotransferases, bilirubin, and creatinine and also prevents hypocalcaemia when measured 6 hr after administration of LPS[1]. S-Methylisothiourea sulfate (1 mg/kg; i.p.) improves 24-hr survival of mice treated with a high dose of LPS (60 mg/kg; i.p.)[1]. Animal Model: Male Wistar rats (260-320 g)[1] Dosage: 0.01 mg/kg, 0.1 mg/kg, 1 mg/kg, 3 mg/kg Administration: Intravenous injection Result: Caused a prompt restoration of the blood pressure to pre-LPS levels at 3 mg/kg dose in LPS (10 mg/kg, i.v.)-treated rats; Inhibits iNOS activity measured in homogenates of lung. |
| References |
| Density | 1.28 |
|---|---|
| Boiling Point | 138.8ºC at 760 mmHg |
| Melting Point | 240-241 °C (dec.)(lit.) |
| Molecular Formula | C2H8N2O4S2 |
| Molecular Weight | 188.226 |
| Flash Point | 37.7ºC |
| Exact Mass | 187.992554 |
| PSA | 158.15000 |
| LogP | 1.47090 |
| Storage condition | Store at RT |
| Stability | Stable. Incompatible with strong oxidizing agents. |
| Water Solubility | 260 g/L (20 ºC) |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
|
| Symbol |
GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H302 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
| Hazard Codes | Xn:Harmful; |
| Risk Phrases | R22 |
| Safety Phrases | S22-S24/25 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| RTECS | UM9200000 |
| HS Code | 2930909090 |
| Precursor 0 | |
|---|---|
| DownStream 10 | |
![2-[2-(isoquinolin-5-ylsulfonylamino)ethyl]guanidine,hydrochloride structure](https://image.chemsrc.com/caspic/489/92564-34-6.png)
| HS Code | 2930909090 |
|---|---|
| Summary | 2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |