S-Methylisothiourea sulfate

Modify Date: 2024-01-02 10:13:14

S-Methylisothiourea sulfate structure	Common Name	S-Methylisothiourea sulfate
	CAS Number	867-44-7	Molecular Weight	188.226
	Density	1.28	Boiling Point	138.8ºC at 760 mmHg
	Molecular Formula	C₂H₈N₂O₄S₂	Melting Point	240-241 °C (dec.)(lit.)
	MSDS	Chinese USA	Flash Point	37.7ºC
	Symbol	GHS07	Signal Word	Warning

Use of S-Methylisothiourea sulfate

S-Methylisothiourea sulfate is a potent, selective and competitive inhibitor of inducible nitric oxide synthase (iNOS). S-Methylisothiourea sulfate exerts beneficial effects in rodent models of septic shock[1].

Name	2-Methyl-2-thiopseudourea sulfate
Synonym	More Synonyms

Description	S-Methylisothiourea sulfate is a potent, selective and competitive inhibitor of inducible nitric oxide synthase (iNOS). S-Methylisothiourea sulfate exerts beneficial effects in rodent models of septic shock[1].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Immunology/Inflammation >> NO Synthase
Target	iNOS[1]
In Vitro	S-Methylisothiourea sulfate is a competitive inhibitor of iNOS activity at the L-arginine site[1]. S-Methylisothiourea sulfate prevents the NO-mediated cytotoxic effect of LPS in cultured macrophages[1]. S-Methylisothiourea sulfate (100 nM-100 μM) exhibits inhibitory effects on LPS (ug/mL)-induced nitrite production in J774.2 macrophages and rat aortic vascular smooth muscle cells[1]. S-Methylisothiourea sulfate(up to 1 mM) does not inhibit the activity of xanthine oxidase, diaphorase, lactate dehydrogenase, monoamine oxidase, catalase, cytochrome P450, or superoxide dismutase[1].
In Vivo	S-Methylisothiourea sulfate (0.01-3 mg/kg; i.v.) dose-dependently reverses the hypotension and the vascular hyporeactivity to vasoconstrictor agents caused by endotoxin LPS in anesthetized rats[1]. S-Methylisothiourea sulfate (5 mg/kg; i.p.; given 2 hr after LPS; 10 mg/kg, i.p.) attenuates the rises in plasma alanine and aspartate aminotransferases, bilirubin, and creatinine and also prevents hypocalcaemia when measured 6 hr after administration of LPS[1]. S-Methylisothiourea sulfate (1 mg/kg; i.p.) improves 24-hr survival of mice treated with a high dose of LPS (60 mg/kg; i.p.)[1]. Animal Model: Male Wistar rats (260-320 g)[1] Dosage: 0.01 mg/kg, 0.1 mg/kg, 1 mg/kg, 3 mg/kg Administration: Intravenous injection Result: Caused a prompt restoration of the blood pressure to pre-LPS levels at 3 mg/kg dose in LPS (10 mg/kg, i.v.)-treated rats; Inhibits iNOS activity measured in homogenates of lung.
References	[1]. C Szabó, et al. Beneficial effects and improved survival in rodent models of septic shock with S-methylisothiourea sulfate, a potent and selective inhibitor of inducible nitric oxide synthase. Proc Natl Acad Sci U S A. 1994 Dec 20; 91(26): 12472–12476.

Density	1.28
Boiling Point	138.8ºC at 760 mmHg
Melting Point	240-241 °C (dec.)(lit.)
Molecular Formula	C₂H₈N₂O₄S₂
Molecular Weight	188.226
Flash Point	37.7ºC
Exact Mass	187.992554
PSA	158.15000
LogP	1.47090
Storage condition	Store at RT
Stability	Stable. Incompatible with strong oxidizing agents.
Water Solubility	260 g/L (20 ºC)

S-Methylisothiourea sulfate MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UM9200000

CAS REGISTRY NUMBER :: 867-44-7

LAST UPDATED :: 199701

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C4-H12-N4-S2.H2-O4-S

MOLECULAR WEIGHT :: 278.40

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 400 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: AD438-895

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 180 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#05644

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 663 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: THERAP Therapie. (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris, France) V.1- 1946- Volume(issue)/page/year: 14,700,1959

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xn:Harmful;
Risk Phrases	R22
Safety Phrases	S22-S24/25
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	UM9200000
HS Code	2930909090

Precursor 0
DownStream 10
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HS Code	2930909090
Summary	2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

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S-Methyl-isothiouronium Hemisulfate

S-METHYLTHIOPSEUDOUREA SULPHATE

2-Methyl-2-thiopseudourea sulfate

2-Methyl-2-thiopseudourea hemisulfate

S-METHYLISOTHIOHARNSTOFF HEMISULFAT

S-methylisothiourea sulfuric acid salt 1:1

S-EIT hemihydrate

2-methyl-2-thiopseudouronium sulfate

S-METHYLISOTHIOURONIUM SULPHATE

2-Methyl-2-thiopseudoureasulfate

S-METHYL-ISO-THIOUREA SULFATE

S-Methylisothiourea Hemisulfate Salt

S-METHYLISOTHIOURONIUM SULPHATE/S-METHYLISOTHIOUREA SULPHATE/2-METHYL-2-THIOPSEUDOUREA SULPHATE

2-METHYL-2-THIOPSEUDOUREA SULFATE (S-METHYLISOTHIOUREA SULFATE)

MFCD00129752

methyl imidothiocarbamate

S-METHYL ISOTHIOUREA SULFATE

Carbamimidothioic acid, methyl ester, sulfate (2:1)

S-methyl-2-thiopseudourea hydrogen sulfate

S-METHYLTHIOURONIUM SULFATE

S-methylisothiourea hydrogensulfate

S-Methyl-ITU

S-MethyliSothourea Sulfate

methyl imidothiocarbamate sulfate

2-Methyl-2-thiopseud

EINECS 212-759-7

S-methyl isothiourea sultate

2-METHYL-2-THIOPSEUDO UREA 14C SULFATE

S-METHYL-ISO-THIOUREA

S-methyl Isothiourea (hemisulfate)

S-METHYLISOTHIOURONIUM SULFATE

5-METHYLISOTHIOUREA HEMISULFATE

Carbamimidothioic acid, methyl ester, sulfate (1:1)

(S)-METHYLISOTHIOUREA SULFATE

METHYLTHIOURONIUMSULPHATE

Methyl carbamimidothioate sulfate (1:1)

S-METHYLTHIOUREA

S-METHYL-2-ISOTHIOUREA HEMISULPHATE

S-methylisothiouronium hydrogensulfate

methyl carbamimidothioate

S-METHYLISOTHIOUREASULFATE

S-METHYLTHIOURONIUM SULFATE FOR SYNTHESIS

S-Methylisothiourea hemisulfate

S-METHYLISOTHIOUREA HEMISULFATE SALT _X000D_

S-Methylisothiourea sulfate

IMINO(METHYLSULFANYL)METHYLAMINE

Amino(methylsulfanyl)methaniminium hydrogen sulfate (1:1:1)

S-Methyl-ITU . sulfate

S-METHYLTHIOURONIUMSULFATE(2:1)

METHYLTHIURONIUMSULPHATE

2-METHYL-ISOTHIOUREA

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: S-Methylisothiourea sulfate
Price: Click To Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: S-Methylisothiourea sulfate
Price: ￥88.0/100g ￥258.0/500g
Purity: 98.0%
Delivery: 2 Day
Contact: Liu jia
Email: 2130147988@qq.com

DC Chemicals Limited
China
Product Name: S-Methylisothiourea sulfate
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
Purity: 98.0%
Delivery: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 2-Methyl-2-thiopseudourea sulfate
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

Henan Tianfu Chemical Co., Ltd.
China
Product Name: (S)-Methylisothiourea sulfate
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Delivery: Inquiry
Contact: Anson
Email: info@tianfuchem.com

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