925681-41-0

925681-41-0 structure

Name: 10-DEBC hydrochloride
Chemical Name: 10H-Phenoxazine-10-butanamine, 2-chloro-N,N-diethyl-, hydrochloride
CAS Number: 925681-41-0
Molecular Formula: C₂₀H₂₆Cl₂N₂O
Molecular Weight: 381.34
Catalog: Signaling Pathways Anti-infection Bacterial
Create Date: 2017-11-14 22:43:22
Modify Date: 2025-08-27 12:25:50
10-DEBC hydrochloride is a selective Akt inhibitor, with an IC50 of 1.28 μM. 10-DEBC hydrochloride is a novel anti-TB compound[1][2].

Name	10H-Phenoxazine-10-butanamine, 2-chloro-N,N-diethyl-, hydrochloride
Synonyms	4-(2-Chloro-10H-phenoxazin-10-yl)-N,N-diethyl-1-butanamine hydrochloride (1:1) 10H-Phenoxazine-10-butanamine, 2-chloro-N,N-diethyl-, hydrochloride (1:1) AKT INHIBITOR X 10-DEBC hydrochloride 4-(2-Chloro-10H-phenoxazin-10-yl)-N,N-diethylbutan-1-amine hydrochloride (1:1)

Description	10-DEBC hydrochloride is a selective Akt inhibitor, with an IC50 of 1.28 μM. 10-DEBC hydrochloride is a novel anti-TB compound[1][2].
Related Catalog	Research Areas >> Infection Signaling Pathways >> PI3K/Akt/mTOR >> Akt Research Areas >> Inflammation/Immunology Signaling Pathways >> Anti-infection >> Bacterial
In Vitro	10-DEBC is found to inhibit the growth of Mtb in whole-cell assay with an IC50 of 12.8 μM, while inhibiting replication of Mtb inside iMACs with an IC50 of 1.5 μM, without host cell toxicity even at the highest concentration of 25 μM[2].
References	[1]. Wei Li, et al. More than just a GPCR ligand: structure-based discovery of thioridazine derivatives as Pim-1 kinase inhibitors. Medicinal Chemistry Communications. [2]. Hyo-Won Han, et al. Drug Discovery Platform Targeting M. tuberculosis with Human Embryonic Stem Cell-Derived Macrophages. Stem Cell Reports. 2019 Dec 10;13(6):980-991.