98968-94-6

98968-94-6 structure

Name: Adipokinetic Hormone II (Locusta migratoria)
Chemical Name: L-Tryptophanamide, 5-oxo-L-prolyl-L-leucyl-L-asparaginyl-L-phenylalanyl-L-seryl-L-alanylglycyl
CAS Number: 98968-94-6
Molecular Formula: C₄₃H₅₇N₁₁O₁₁
Molecular Weight: 903.98000
Catalog: Research Areas Metabolic Disease
Create Date: 2018-06-12 06:14:19
Modify Date: 2024-01-12 22:43:59
Adipokinetic hormone II (Locusta migratoria) (Lom-AKH-II) is a insect adipokinetic hormone (AKH), enhances fat body cAMP levels in vitro. Insect adipokinetic hormones (AKHs) controls flight-directed mobilization of carbohydrate and lipid from fat body stores, which depends on AKH receptor(s) coupling to cAMP formation and glycogen phosphorylase activation via the stimulatory guanine nucleotide-binding protein (Gs)[1][3].

Name	L-Tryptophanamide, 5-oxo-L-prolyl-L-leucyl-L-asparaginyl-L-phenylalanyl-L-seryl-L-alanylglycyl
Synonyms	Chromatophorotropin, red-pigment-concentrating (Pandalus borealis) 6-L-alanine- ADIPOKINETIC HORMONE II (LOCUSTA MIGRATORIA) Lom-AKH-2 ADIPOKINETIC HORMONE II Adipokinetic hormone II (Locusta migratoria) Locust adipokinetic hormone II Lom-AKH-II

Description	Adipokinetic hormone II (Locusta migratoria) (Lom-AKH-II) is a insect adipokinetic hormone (AKH), enhances fat body cAMP levels in vitro. Insect adipokinetic hormones (AKHs) controls flight-directed mobilization of carbohydrate and lipid from fat body stores, which depends on AKH receptor(s) coupling to cAMP formation and glycogen phosphorylase activation via the stimulatory guanine nucleotide-binding protein (Gs)[1][3].
Related Catalog	Research Areas >> Metabolic Disease
In Vitro	Adipokinetic hormone II (Locusta migratoria) (radiolabeled; 1 pmol in 10 μL of 10% methanol; 30 min on ice, and repeated for 2 h at 30 ℃) shows no association with one of the larger protein components, indicating a lack of separate transporting or carrier protein in the hemolymph[1]. Adipokinetic hormones (AKHs) are known to be involved in insect immunity and shows the mechanism of metabolic stimulation, leading a significant increase in carbon dioxide production, and efficacy increase of toxins produced by I. fumosorosea in the cockroach's body[2]. Adipokinetic hormone II is more effective than hormone I in bringing about an accumulation of cAMP in the fat body[4].
In Vivo	Adipokinetic hormone II (Locusta migratoria) (1 pmol in 10 μL of 10% methanol; injection) plays its own biol. role in the overall syndrome of insect flight, with different half-lives of 40 min and 37 min during rest and flight, respectively[1].