73-78-9
73-78-9 structure
- Name: Lidocaine hydrochloride
- Chemical Name: lidocaine hydrochloride
- CAS Number: 73-78-9
- Molecular Formula: C14H23ClN2O
- Molecular Weight: 270.798
- Catalog: API Anesthetic Agents Local anesthetics
- Create Date: 2018-02-03 08:00:00
- Modify Date: 2026-06-30 17:23:58
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Lidocaine Hcl salt, an amide local anesthetic, has anti-inflammatory properties in vitro and in vivo, possibly due to an attenuation of pro-inflammatory cytokines, intracellular adhesion molecule-1 (ICAM-1), and reduction of neutrophils influx.Target: Lidocaine is a common local anesthetic and antiarrhythmic drug. Lidocaine is used topically to relieve itching, burning and pain from skin inflammations, injected as a dental anesthetic or as a local anesthetic for minor surgery. Lidocaine, the first amino amide–type local anesthetic, was first synthesized under the name xylocaine by Swedish chemist Nils Lofgren in 1943. His colleague Bengt Lundqvist performed the first injection anesthesia experiments on himself.Lidocaine is approximately 95% metabolized (dealkylated) in the liver by CYP3A4 to the pharmacologically-active metabolites monoethylglycinexylidide (MEGX) and then subsequently to the inactive glycine xylidide. MEGX has a longer half life than lidocaine but also is a less potent sodium channel blocker. The elimination half-life of lidocaine is approximately 90–120 minutes in most patients. This may be prolonged in patients with hepatic impairment (average 343 minutes) or congestive heart failure (average 136 minutes).
| Name | lidocaine hydrochloride |
|---|---|
| Synonyms |
Lidocaine hydrochloride 2000,BP98
Lidocaine (hydrochloride) 2-(diethylamino)-N-(2,6-dimethylphenyl)acetamide,hydrochloride 2-diethylamino-2’,6’-acetoxylididehydrochloride xylocd n-(diethylaminoacetyl)-2,6-dimethylanilinehydrochloride 2-(Diethylamino)-N-(2,6-dimethylphenyl)acetamidhydrochlorid XYLOCAINE HYDROCHLORIDE omega-diethylamino-2,6-dimethylacetanilidehydrochloride N-(2,6-Dimethylphenyl)-N,N-diethylglycinamide hydrochloride (1:1) leostesinhydrochloride v262 xylestesinhydrochloride xyloneural MFCD00034865 A-(DIETHYLAMINO)-2 6-DIMETHYLACETANILIDE HYDROCHLORIDE 2-(diéthylamino)-N-(2,6-diméthylphényl)acétamide chlorhydrate Licain Monohydrate Basicaina Monohydrate LIGNOCAINE HYDROCHLORIDE isicainehydrochloride Lidocaie Hydrochloride LIDOCAINE HYDROCHLORIDE (LIGNOCAINE HYDROCHLORIDE) Heweneural Monohydrate 2-(Diethylamino)-N-(2,6-dimethylphenyl)acetamide, hydrochloride (1:1) Acetamide, 2-(diethylamino)-N-(2,6-dimethylphenyl)-, monohydrochloride 2-(diethylamino)-n-(2,6-dimethylphenyl)-acetamid monohydrochloride alpha-diethylamino-2,6-acetoxylidine hydrochloride anestacon hydrochloride duncaine hydrochloride N-(2,6-dimethylphenyl)-N,N-diethylglycinamide hydrochloride A-(DIETHYLAMINO)-2 6-DIMETHYLACETANILIDE H lignocaine hydrochloride xycainehydrochloride ALPHA-(DIETHYLAMINO)-2',6'-ACETOXYLIDIDE HYDROCHLORIDE Acetamide, 2-(diethylamino)-N-(2,6-dimethylphenyl)-, hydrochloride (1:1) anestaconhydrochloride avocainhydrochloride Lidothesin Laryng-O-jet N-(2,6-dimethylphenyl)-N2,N2-diethylglycinamide hydrochloride Lidocaine HCL (BP alpha-diethylamino-2,6-acetoxylidinehydrochloride Lidocaine HCl Phmaceutical Raw Material Lidocaine kf-wang(at)kf-chem.com 2-(diethylamino)-n-(2,6-dimethylphenyl)-acetamidmonohydrochloride 2-(diethylamino)-N-(2,6-dimethylphenyl)acetamide hydrochloride Lidocaine hydrochloride 2-(Diethylamino)-N-(2,6-dimethylphenyl)-acetamide hydrochloride duncainehydrochloride EINECS 200-803-8 2',6'-Acetoxylidide, 2-(diethylamino)-, monohydrochloride (8CI) Xylocard lidocainhydrochloride LIONCAINEHYDROCHLORIDE Dynexan Monohydrate Lidocaine Hydrochloride Phmaceutical Raw Materials -9 Lidocaine HCl CAS NO.-9 LIDOCAINE HCL lidothesinhydrochloride Xyloneural Lidocaine for Local anesthesia Acetamide,2-(diethylamino)-N-(2,6-dimethylphenyl)-,monohydrochloride 6’-acetoxylidide,2-(diethylamino)-2monohydrochloride (Diethylamino)-2',6'-acetoxylidide Monohydrochloride Coluracetam powder s202 Lithium Claviate Lidociane Hydrochloride Xilina hydrochloride Acetamide,2-(diethylamino)-N-(2,6-diethylphenyl)-,monohydrochloride 2-(Diethylamino)-N-(2,6-dimethylphenyl)-acetamide hydrochloride 6’-acetoxylidide,2-(diethylamino)-2hydrochloride Lidocaine hydrochloride (skype：lisa_21819) 2-DIETHYLAMINO-N-(2'6'-DIMETHYLPHENYL)ACETAMIDE HCL a-(diethylamino)-26-acetoxylidideHCl 2-(Diethylamino)-N-(2,6-dimethylphenyl)acetamide monohydrochloride rucainahydrochloride 2-DIETHYLAMINO-N-[2,6-DIMETHYLPHENYL]ACETAMIDE HCL Lidocaton Batixim Monohydrate a-(diethylamino)-26-acetoxylididehydrochloride xylocainehydrochloride LIDOCAINE HYDROCHLORIDE ANHYDROUS Lidocainhydrochlorid Lidocaine hcl powder xylotoxhydrochloride 2N2&1VMR B1 F1 &&HCl xylocitinhydrochloride |
| Description | Lidocaine Hcl salt, an amide local anesthetic, has anti-inflammatory properties in vitro and in vivo, possibly due to an attenuation of pro-inflammatory cytokines, intracellular adhesion molecule-1 (ICAM-1), and reduction of neutrophils influx.Target: Lidocaine is a common local anesthetic and antiarrhythmic drug. Lidocaine is used topically to relieve itching, burning and pain from skin inflammations, injected as a dental anesthetic or as a local anesthetic for minor surgery. Lidocaine, the first amino amide–type local anesthetic, was first synthesized under the name xylocaine by Swedish chemist Nils Lofgren in 1943. His colleague Bengt Lundqvist performed the first injection anesthesia experiments on himself.Lidocaine is approximately 95% metabolized (dealkylated) in the liver by CYP3A4 to the pharmacologically-active metabolites monoethylglycinexylidide (MEGX) and then subsequently to the inactive glycine xylidide. MEGX has a longer half life than lidocaine but also is a less potent sodium channel blocker. The elimination half-life of lidocaine is approximately 90–120 minutes in most patients. This may be prolonged in patients with hepatic impairment (average 343 minutes) or congestive heart failure (average 136 minutes). |
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| Related Catalog | |
| References |
| Boiling Point | 350.8ºC at 760 mmHg |
|---|---|
| Melting Point | 80-82°C |
| Molecular Formula | C14H23ClN2O |
| Molecular Weight | 270.798 |
| Flash Point | 166ºC |
| Exact Mass | 270.149902 |
| PSA | 32.34000 |
| LogP | 3.45870 |
| Storage condition | Refrigerator |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
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| RIDADR | 3249 |
|---|---|
| Packaging Group | III |
| Hazard Class | 6.1(b) |
| HS Code | 2924299090 |
| Precursor 0 | |
|---|---|
| DownStream 2 | |
| HS Code | 2924299090 |
|---|---|
| Summary | 2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |