- Shanghai Jizhi Biochemical Technology Co., Ltd
- China
- Product Name: 3-Chlorodiphenylamine
- Price: ￥5269.0/5g ￥Inquiry/1mg ￥1759.0/1g
- Purity: 97.0%
- Stocking Period: 3 Day
- Contact: Liu jia
- DC Chemicals Limited
- China
- Product Name: 3 Cl-DPA
- Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
- Purity: 98.0%
- Stocking Period: 3 Day
- Contact: Tony Cao
- Dayang Chem (Hangzhou) Co., Ltd.
- China
- Product Name: 3-Chlorodiphenylamine
- Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
- Purity: 98.0%
- Stocking Period: Inquiry
- Contact: Ms Wang
- Zhejiang Hangyu API Co., Ltd
- China
- Product Name: 3-CHLORODIPHENYLAMINE
- Price: ￥Inquiry/1kg
- Purity: 99.5%
- Stocking Period: Inquiry
- Contact: Vinnie
101-17-7
101-17-7 structure
- Name: 3-Chlorodiphenylamine
- Chemical Name: 3-chloro-N-phenylaniline
- CAS Number: 101-17-7
- Molecular Formula: C12H10ClN
- Molecular Weight: 203.667
- Catalog: Pharmaceutical intermediate Diphenylamine intermediate
- Create Date: 2018-04-08 08:00:00
- Modify Date: 2024-01-02 22:17:54
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3-Chlorodiphenylamine is a high affinity Ca2+ sensitizer of cardiac muscle. 3-Chlorodiphenylamine is based on diphenylamine and binds to the isolated N-domain of cardiac troponin C (cTnC) (Kd=6 µM). 3-Chlorodiphenylamine is an excellent starting scaffold for the development of more potent Ca2+-sensitizing compounds due to its small size, and can be used for systolic heart failure research[1].
| Name | 3-chloro-N-phenylaniline |
|---|---|
| Synonyms |
Benzenamine, 3-chloro-N-phenyl-
(3-Chlor-phenyl)-phenyl-amin EINECS 202-922-0 3-chloro-N-phenyl-aniline 3-Chloro-N-phenyl-benzenamine N-(3-Chlorophenyl)aniline MFCD00000590 N-(m-Chlorophenyl)aniline (3-chlorophenyl)phenylamine (3-Cl-C6H4)PhNH m-Chlorodiphenylamine 3-Chloro-N-phenylaniline 3-Chlorodiphenylamine Benzenamine,3-chloro-N-phenyl N-(3-chlorophenyl)-N-phenylamine |
| Description | 3-Chlorodiphenylamine is a high affinity Ca2+ sensitizer of cardiac muscle. 3-Chlorodiphenylamine is based on diphenylamine and binds to the isolated N-domain of cardiac troponin C (cTnC) (Kd=6 µM). 3-Chlorodiphenylamine is an excellent starting scaffold for the development of more potent Ca2+-sensitizing compounds due to its small size, and can be used for systolic heart failure research[1]. |
|---|---|
| Related Catalog | |
| Target |
Kd: 6 µM (N-domain of cardiac troponin C (cTnC)) Kd: 10 µM (cNTnC–cSp chimera)[1] |
| In Vitro | 3-Chlorodiphenylamine is able to bind highly (Kd=10 µM) to a chimeric protein consisting of the regulatory N-domain of cTnC (cNTnC) and the switch region of cTnI (cNTnC–cSp chimera)[1]. 3-Chlorodiphenylamine (100 µM) results in a 1.5-fold increase in the Ca2+ sensitivity of force development without altering the maximal or resting forces in skinned ventricular trabeculae[1]. 3-Chlorodiphenylamine (25-100 µM) increases Ca2+ sensitivity of the N-domain of intact cTnC after reconstitution into the cTn complex (cTnC complexed with cTnI and cTnT) in a concentration-dependent manner. It exhibits pCa50s with 6.39±0.01, 6.65±0.01, and 6.73±0.02 in the presence of 25, 50, and 100 µM 3-Chlorodiphenylamine, respectively[1]. |
| References |
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 337.8±0.0 °C at 760 mmHg |
| Melting Point | 112 °C |
| Molecular Formula | C12H10ClN |
| Molecular Weight | 203.667 |
| Flash Point | 147.4±23.2 °C |
| Exact Mass | 203.050171 |
| PSA | 12.03000 |
| LogP | 3.86 |
| Vapour Pressure | 0.0±0.7 mmHg at 25°C |
| Index of Refraction | 1.643 |
| Hazard Codes | Xn |
|---|---|
| Risk Phrases | R20/21/22 |
| Safety Phrases | S28-S36/37 |
| HS Code | 2921440000 |
| Precursor 9 | |
|---|---|
| DownStream 10 | |
| HS Code | 2921440000 |
|---|---|
| Summary | 2921440000. diphenylamine and its derivatives; salts thereof. VAT:17.0%. Tax rebate rate:17.0%. . MFN tariff:6.5%. General tariff:30.0% |