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142-46-1

142-46-1 structure
142-46-1 structure

Name Hydrazodicarbothioamide
Synonyms MFCD00014471
DITHIOUREA
bithiourea
bisthiourea
usafb-44
usafb-55
2,5-dithiourea
DITHIODIUREA
2,5-Dithiobiurea
DITHIOBIUREA
EINECS 205-537-6
usafek-p-6281
1,2-Hydrazinedicarbothioamide
1-thiocarbamoylthiosemicarbazide
N,N'-bis-(amidothiocarbonyl)-hydrazine
hydrazodithiocarbamide
hydrazine-1,2-dicarbothioamide
Density 1.6±0.1 g/cm3
Boiling Point 291.6±23.0 °C at 760 mmHg
Melting Point 212 °C (dec.)(lit.)
Molecular Formula C2H6N4S2
Molecular Weight 150.226
Flash Point 130.1±22.6 °C
Exact Mass 150.003387
PSA 140.28000
LogP -1.12
Vapour Pressure 0.0±0.6 mmHg at 25°C
Index of Refraction 1.771
Name: 2 5-Dithiobiurea 99% Material Safety Data Sheet
Synonym: Bisthiocarbamyl Hydrazine; N,N'-Bisthiocarbamyl Hydrazine
CAS: 142-46-1
Section 1 - Chemical Product MSDS Name:2 5-Dithiobiurea 99% Material Safety Data Sheet
Synonym:Bisthiocarbamyl Hydrazine; N,N'-Bisthiocarbamyl Hydrazine

Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS
CAS# Chemical Name content EINECS#
142-46-1 2,5-Dithiobiurea 99 205-537-6
Hazard Symbols: T
Risk Phrases: 23/24/25 43 45

Section 3 - HAZARDS IDENTIFICATION
EMERGENCY OVERVIEW
Toxic by inhalation, in contact with skin and if swallowed. May cause sensitization by skin contact. May cause cancer.The toxicological properties of this material have not been fully investigated.
Potential Health Effects
Eye:
May cause eye irritation.
Skin:
May cause skin irritation. May cause skin sensitization, an allergic reaction, which becomes evident upon re-exposure to this material.
Ingestion:
May cause irritation of the digestive tract. The toxicological properties of this substance have not been fully investigated.
Inhalation:
May cause respiratory tract irritation. The toxicological properties of this substance have not been fully investigated.
Chronic:
Repeated or prolonged exposure may cause allergic reactions in sensitive individuals.

Section 4 - FIRST AID MEASURES
Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.
Skin:
Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse. Destroy contaminated shoes.
Ingestion:
Never give anything by mouth to an unconscious person. Get medical aid. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water.
Inhalation:
Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
Notes to Physician:

Section 5 - FIRE FIGHTING MEASURES
General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion.
Extinguishing Media:
Use agent most appropriate to extinguish fire. Use water spray, dry chemical, carbon dioxide, or appropriate foam.

Section 6 - ACCIDENTAL RELEASE MEASURES
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Vacuum or sweep up material and place into a suitable disposal container. Clean up spills immediately, observing precautions in the Protective Equipment section. Avoid generating dusty conditions.
Provide ventilation.

Section 7 - HANDLING and STORAGE
Handling:
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use with adequate ventilation. Minimize dust generation and accumulation. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation.
Storage:
Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.

Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
Engineering Controls:
Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate ventilation to keep airborne concentrations low.
Exposure Limits CAS# 142-46-1: Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant respirator use.

Section 9 - PHYSICAL AND CHEMICAL PROPERTIES

Physical State: Powder
Color: white
Odor: none reported
pH: Not available.
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: Not available.
Freezing/Melting Point: 200.00 - 203.00 deg C
Autoignition Temperature: Not applicable.
Flash Point: Not applicable.
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature:
Solubility in water: negligible
Specific Gravity/Density:
Molecular Formula: C2H6N4S2
Molecular Weight: 150.22

Section 10 - STABILITY AND REACTIVITY
Chemical Stability:
Stable under normal temperatures and pressures.
Conditions to Avoid:
Incompatible materials, dust generation, excess heat, strong oxidants.
Incompatibilities with Other Materials:
Oxidizing agents.
Hazardous Decomposition Products:
Nitrogen oxides, carbon monoxide, irritating and toxic fumes and gases, carbon dioxide, hydrogen sulfide, sulfur oxides (SOx), including sulfur oxide and sulfur dioxide.
Hazardous Polymerization: Has not been reported

Section 11 - TOXICOLOGICAL INFORMATION
RTECS#:
CAS# 142-46-1: EC1460000 LD50/LC50:
Not available.
Carcinogenicity:
2,5-Dithiobiurea - Not listed by ACGIH, IARC, or NTP.
Other:
See actual entry in RTECS for complete information.

Section 12 - ECOLOGICAL INFORMATION


Section 13 - DISPOSAL CONSIDERATIONS
Dispose of in a manner consistent with federal, state, and local regulations.

Section 14 - TRANSPORT INFORMATION

IATA
Not regulated as a hazardous material.
IMO
Not regulated as a hazardous material.
RID/ADR
Not regulated as a hazardous material.

Section 15 - REGULATORY INFORMATION

European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: T
Risk Phrases:
R 45 May cause cancer.
R 23/24/25 Toxic by inhalation, in contact with skin
and if swallowed.
R 43 May cause sensitization by skin contact.
Safety Phrases:
S 53 Avoid exposure - obtain special instructions
before use.
S 28A After contact with skin, wash immediately with
plenty of water.
S 37 Wear suitable gloves.
S 45 In case of accident or if you feel unwell, seek
medical advice immediately (show the label where
possible).
WGK (Water Danger/Protection)
CAS# 142-46-1: No information available.
Canada
CAS# 142-46-1 is listed on Canada's NDSL List.
CAS# 142-46-1 is not listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 142-46-1 is listed on the TSCA inventory.


SECTION 16 - ADDITIONAL INFORMATION
N/A

CHEMICAL IDENTIFICATION

RTECS NUMBER :
EC1460000
CHEMICAL NAME :
Biurea, 2,5-dithio-
CAS REGISTRY NUMBER :
142-46-1
BEILSTEIN REFERENCE NO. :
1723178
LAST UPDATED :
199701
DATA ITEMS CITED :
7
MOLECULAR FORMULA :
C2-H6-N4-S2
MOLECULAR WEIGHT :
150.24
WISWESSER LINE NOTATION :
SUYZMMYZUS

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD - Lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
655 gm/kg/78W-C
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria Liver - tumors
TYPE OF TEST :
TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1310 gm/kg/78W-C
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria Liver - tumors

MUTATION DATA

TYPE OF TEST :
Sister chromatid exchange
TEST SYSTEM :
Rodent - hamster Ovary
DOSE/DURATION :
145 mg/L
REFERENCE :
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987- Volume(issue)/page/year: 10(Suppl 10),1,1987
Hazard Codes Xi:Irritant;
Risk Phrases R36/37/38
Safety Phrases S26-S37/39
WGK Germany 3
RTECS EC1460000
HS Code 2930909090

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142-46-1 structure

142-46-1

Literature: Lee, Boong Won; Lee, Seung Dal Tetrahedron Letters, 2000 , vol. 41, # 20 p. 3883 - 3886

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142-46-1 structure

142-46-1

Literature: European Journal of Medicinal Chemistry, , vol. 64, p. 54 - 61

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142-46-1 structure

142-46-1

Literature: Chemische Berichte, , vol. 29, p. 2510

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142-46-1 structure

142-46-1

Literature: Chemische Berichte, , vol. 28, p. 949

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142-46-1 structure

142-46-1

Detail
Literature: Journal of Organic Chemistry USSR (English Translation), , vol. 18, p. 2273 - 2276 Zhurnal Organicheskoi Khimii, , vol. 18, # 12 p. 2577 - 2580

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142-46-1 structure

142-46-1

Literature: Svensk Kemisk Tidskrift, , vol. 67, p. 361,363

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142-46-1 structure

142-46-1

Literature: Svensk Kemisk Tidskrift, , vol. 64, p. 121,129
HS Code 2930909090
Summary 2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%