143388-64-1
143388-64-1 structure
- Name: Naratriptan Hydrochloride
- Chemical Name: Naratriptan hydrochloride
- CAS Number: 143388-64-1
- Molecular Formula: C17H26ClN3O2S
- Molecular Weight: 371.925
- Catalog: Biochemical Inhibitor Neuronal Signaling 5-HT Receptor Agonist
- Create Date: 2018-06-25 15:19:30
- Modify Date: 2026-07-01 18:23:02
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Naratriptan hydrochloride is a selective 5-HT1 receptor subtype agonist and is a triptan drug that is used for the treatment of migraine headaches.Target: 5-HT1 ReceptorNaratriptan is a triptan drug marketed by GlaxoSmithKline and is used for the treatment of migraine headaches. Naratriptan is available in 2.5 mg tablets. It is a selective 5-HT1 receptor subtype agonist. Naratriptan is used for the treatment of the acute migraine attacks and the symptoms of migraine, including severe, throbbing headaches that sometimes are accompanied by nausea and sensitivity to sound or light.The causes of migraine are not clearly understood; however, the efficacy of naratriptans and other triptans is believed to be due to their activity as 5HT (serotonin) agonists.A meta-analysis of 53 clinical trials has shown that all triptans are effective for treating migraine at marketed doses and that naratriptan, although less effective than sumatriptan and rizatriptan was more effective than placebo in reducing migraine symptoms at two hours and efficacy was demonstrated in almost two thirds of subjects after four hours of treatment.
| Name | Naratriptan hydrochloride |
|---|---|
| Synonyms |
N-Methyl-3-(1-methyl-4-piperidinyl)-1H-indole-5-ethanesulfonamide hydrochloride
1H-Indole-5-ethanesulfonamide,N-methyl-3-(1-methyl-4-piperidinyl)-,hydrochloride 1H-Indole-5-ethanesulfonaMide,N-Methyl-3-(1-Methyl-4-piperidinyl)-, hydrochloride (1:1) N-Methyl-2-[3-(1-methylpiperidin-4-yl)-1H-indol-5-yl]ethansulfonamidhydrochlorid N-Methyl-3-(1-methyl-4-piperidinyl)-1H-Indole-5-ethanesulfonamide monohydrochloride 1H-Indole-5-ethanesulfonaMide,N-Methyl-3-(1-Methyl-4-piperidinyl N-Methyl-2-[3-(1-methylpiperidin-4-yl)-1H-indol-5-yl]ethanesulfonamide hydrochloride (1:1) Amerge Natryptan hydrochloride 85548A hydrochloride naramig N-Methyl-2-[3-(1-methyl-4-piperidyl)-1H-indol-5-yl]-ethanesulfonamide Hydrochloride N-Methyl-2-(3-(1-Methylpiperidin-4-yl)-1H-indol-5-yl)ethanesulfonaMide hydrochloride NATRIPTAN HYDROCHLORIDE F0C3600.998MG/MG(AI) N-methyl-2-[3-(1-methylpiperidin-4-yl)-1H-indol-5-yl]ethanesulfonamide,hydrochloride Amerge GR-85548A N-Methyl-3-(1-methyl-4-piperidinyl)-1H-indole-5-ethanesulfonamide hydrochloride NATRIPTAN HYDROCHLORIDE F0C36099%8MG/MG(AI) Natriptan HCl -85548A HCl) Natriptan Hydrochloride //BP Niptan Hydrochloride Namig Naratriptan monohydrochloride Natriptan Hydrochloride Natriptan monohydrochloride 1H-Indole-5-ethanesulfonamide, N-methyl-3-(1-methyl-4-piperidinyl)-, hydrochloride (1:1) 2-[3-(1-Methyl- piperidin-4-yl) -1H-indol-5-yl]- ethanesulfonic acid methylamide. Hydrochloride Natriptan HydrochlorideQ: What is Natriptan Hydrochloride Q: What is the CAS Number of Natriptan Hydrochloride Q: What is the storage condition of Natriptan Hydrochloride N-méthyl-2-[3-(1-méthylpipéridin-4-yl)-1H-indol-5-yl]éthanesulfonamide chlorhydrate Amerge,GR-85548A,N-Methyl-3-(1-methyl-4-piperidinyl)-1H-indole-5-ethanesulfonamide hydrochloride Natriptan hydrochloride, 10 mM in DMSO 85548A N-Methyl-2-[3-(1-methyl-4-piperidinyl)-1H-indol-5-yl]ethanesulfonamide hydrochloride (1:1) N-Methyl-3-(1-methylpiperidin-4-yl)-1H-indole-5-ethanesulfonamide hydrochloride Natriptan Nitrate N-Methyl-2-(3-(1-methylpiperidin-4-yl)-1H-indol-5-yl)ethane-1-sulfonamide hydrochloride |
| Description | Naratriptan hydrochloride is a selective 5-HT1 receptor subtype agonist and is a triptan drug that is used for the treatment of migraine headaches.Target: 5-HT1 ReceptorNaratriptan is a triptan drug marketed by GlaxoSmithKline and is used for the treatment of migraine headaches. Naratriptan is available in 2.5 mg tablets. It is a selective 5-HT1 receptor subtype agonist. Naratriptan is used for the treatment of the acute migraine attacks and the symptoms of migraine, including severe, throbbing headaches that sometimes are accompanied by nausea and sensitivity to sound or light.The causes of migraine are not clearly understood; however, the efficacy of naratriptans and other triptans is believed to be due to their activity as 5HT (serotonin) agonists.A meta-analysis of 53 clinical trials has shown that all triptans are effective for treating migraine at marketed doses and that naratriptan, although less effective than sumatriptan and rizatriptan was more effective than placebo in reducing migraine symptoms at two hours and efficacy was demonstrated in almost two thirds of subjects after four hours of treatment. |
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| Related Catalog | |
| References |
| Boiling Point | 541.3ºC at760mmHg |
|---|---|
| Melting Point | 234-236ºC |
| Molecular Formula | C17H26ClN3O2S |
| Molecular Weight | 371.925 |
| Flash Point | 281.2ºC |
| Exact Mass | 371.143433 |
| PSA | 73.58000 |
| LogP | 4.28040 |
| Vapour Pressure | 8.81E-12mmHg at 25°C |
| Storage condition | -20°C Freezer |
| Water Solubility | H2O: ≥10mg/mL |
| Symbol |
GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H319 |
| Precautionary Statements | P305 + P351 + P338 |
| Hazard Codes | Xi |
| Risk Phrases | 36 |
| Safety Phrases | 26 |
| RIDADR | NONH for all modes of transport |