25392-41-0

25392-41-0 structure

Name: 4-(Chloromethyl)-7-hydroxy-2H-chromen-2-one
Chemical Name: 4-(chloromethyl)-7-hydroxychromen-2-one
CAS Number: 25392-41-0
Molecular Formula: C₁₀H₇ClO₃
Molecular Weight: 210.614
Catalog: Research Areas Cancer
Create Date: 2018-11-23 16:43:34
Modify Date: 2024-01-02 12:54:04
4-(Chloromethyl)-7-hydroxycoumarin (compound 4) is a hydroxycoumarin derivative with potent antioxidant effect and high hydroxyl radical-scavenging property. 4-(Chloromethyl)-7-hydroxycoumarin contains a methyl group and a chlorine group in the heterocyclic ring. A series of coumarins incorporating hydroxy-, chloro- and/or chloromethyl-moieties has been investigated as potent inhibitors of the zinc enzyme carbonic anhydrase, expecially tumor-associated isoforms CA IX and XII[1][2].

Name	4-(chloromethyl)-7-hydroxychromen-2-one
Synonyms	2H-1-Benzopyran-2-one, 4-(chloromethyl)-7-hydroxy- 4-Chloromethyl-7-hydroxychromen-2-one 6-hydroxy-1-chloromethyl-3-oxo-3H-benzopyran 4-(chloromethyl)-7-hydroxy-2H-2-chromenone 4-(chloromethyl)-7-hydroxy-2H-chrome-2-one chloromethylhydroxychromenone 4-(Chloromethyl)-7-hydroxy-2H-chromen-2-one CellHunt Blue CMHC [4-Chloromethyl-7-hydroxycoumarin] 4-(Chloromethyl)-7-hydroxycoumarin 7-hydroxy-4-chloromethylcoumarin

Description	4-(Chloromethyl)-7-hydroxycoumarin (compound 4) is a hydroxycoumarin derivative with potent antioxidant effect and high hydroxyl radical-scavenging property. 4-(Chloromethyl)-7-hydroxycoumarin contains a methyl group and a chlorine group in the heterocyclic ring. A series of coumarins incorporating hydroxy-, chloro- and/or chloromethyl-moieties has been investigated as potent inhibitors of the zinc enzyme carbonic anhydrase, expecially tumor-associated isoforms CA IX and XII[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others
References	[1]. Fernanda Pérez-Cruz, et al. Selected hydroxycoumarins as antioxidants in cells: physicochemical and reactive oxygen species scavenging studies. 2013, Oct. 26(10):773-783. [2]. Knaus E E , et al. Phenylethynylbenzenesulfonamide regioisomers strongly and selectively inhibit the transmembrane, tumor-associated carbonic anhydrase isoforms IX and XII over the cytosolic isoforms I and II[J]. Bioorganic & Medicinal Chemistry Letters, 2011, 21(19):5892-5896.

Hazard Codes	Xi
HS Code	2932209090

638-07-3

108-46-3

~94%

25392-41-0

32807-28-6

108-46-3

~85%

25392-41-0

Literature: Sharghi, Hashem; Jokar, Mahboubeh Heterocycles, 2007 , vol. 71, # 12 p. 2721 - 2733

HS Code	2932209090
Summary	2932209090. other lactones. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%