154226-60-5
154226-60-5 structure
- Name: Omuralide
- Chemical Name: CLASTO-LACTACYSTIN β-LACTONE
- CAS Number: 154226-60-5
- Molecular Formula: C10H15NO4
- Molecular Weight: 213.230
- Create Date: 2017-07-14 19:53:55
- Modify Date: 2026-07-03 13:25:41
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A potent 20S proteasome inhibitor with IC50 of 49 nM (inhibition of proteasomal chymotrypsin-like proteolytic activity)..
| Name | CLASTO-LACTACYSTIN β-LACTONE |
|---|---|
| Synonyms |
Clasto-lactacystin (OMuralide)
LACTACYSTIN, CLASTO-, BETA-LACTONE (3S,4S,7R,8S)-8-Hydroxy-3-isopropyl-7-methyl-2-oxa-5-azaspiro[3.4]octane-1,6-dione Tri-p-tolylstibine Clasto-Lactacystin Beta-lactone 1-(1-Hydroxy-2-methylpropyl)-4-methyl-6-oxa-2-azabicyclo[3.2.0]heptane-3,7-dione Stibine,tri-p-tolyl OMURALIDE clasto-Lactacystin beta-lactone, 20S proteasome inhibitor 5,6,7,12,6'-pentamethoxy-2-methyl-berbam-1'-ene BETA-CLASTOLACTACYSTIN clasto-lactacystin β-lactone (1R,4R,5S)-1-[(1S)-1-Hydroxy-2-Methylpropyl]-4-Methyl-6-oxa-2-azabicyclo[3.2.0]htane-3,7-dione 6-Oxa-2-azabicyclo[3.2.0]htane-3,7-dione, 1-[(1S)-1-hydroxy-2-methylpropyl]-4-methyl-, (1R,4R,5S) CLASTO-LACTACYSTIN BETA-LACTONE Tri-p-tolylantimony 1R-[1S-1HYDROXY-2-METHYLPROPYL]-4R-METHYL-6-OXA-2-AZABICYCLO[3.2.0]HTANE-3,7-DIONE |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 462.9±45.0 °C at 760 mmHg |
| Molecular Formula | C10H15NO4 |
| Molecular Weight | 213.230 |
| Flash Point | 233.7±28.7 °C |
| Exact Mass | 213.100113 |
| PSA | 75.63000 |
| LogP | -1.40 |
| Vapour Pressure | 0.0±2.6 mmHg at 25°C |
| Index of Refraction | 1.534 |
| Symbol |
GHS06 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H301-H315-H319-H335 |
| Precautionary Statements | P261-P301 + P310-P305 + P351 + P338 |
| RIDADR | UN 2811 6.1 / PGIII |
| Precursor 4 | |
|---|---|
| DownStream 0 | |
![(1R,4R,5S)-1-((S)-1-hydroxy-2-methylpropyl)-2-(4-methoxybenzyl)-4-methyl-6-oxa-2-azabicyclo[3.2.0]heptane-3,7-dione structure](https://image.chemsrc.com/caspic/081/212772-65-1.png)
