168982-69-2

168982-69-2 structure

Name: N-3-oxo-dodecanoyl-L-homoserine lactone
Chemical Name: 3-oxo-N-[(3S)-2-oxooxolan-3-yl]dodecanamide
CAS Number: 168982-69-2
Molecular Formula: C₁₆H₂₇NO₄
Molecular Weight: 297.390
Catalog: Signaling Pathways Anti-infection Bacterial
Create Date: 2018-10-23 18:03:02
Modify Date: 2024-01-02 11:05:39
N-3-oxo-dodecanoyl-L-Homoserine lactone (3-oxo-C12-HSL) is a bacterial quorum-sensing signaling molecule produced by P. aeruginosa and strains of the B. cepacia complex[1][2].Quorum sensing is a regulatory system used by bacteria for controlling gene expression in response to increasing cell density.N-3-oxo-dodecanoyl-L-Homoserine lactone induces the production of IL-8 in 16HBE human bronchial epithelial cells[3].

Name	3-oxo-N-[(3S)-2-oxooxolan-3-yl]dodecanamide
Synonyms	Dodecanamide, 3-oxo-N-[(3S)-tetrahydro-2-oxo-3-furanyl]- OHN 3-oxo-C12-HSL 3-oxo-C12-AHL 3-Oxo-N-[(3S)-2-oxotetrahydro-3-furanyl]dodecanamide

Description	N-3-oxo-dodecanoyl-L-Homoserine lactone (3-oxo-C12-HSL) is a bacterial quorum-sensing signaling molecule produced by P. aeruginosa and strains of the B. cepacia complex[1][2].Quorum sensing is a regulatory system used by bacteria for controlling gene expression in response to increasing cell density.N-3-oxo-dodecanoyl-L-Homoserine lactone induces the production of IL-8 in 16HBE human bronchial epithelial cells[3].
Related Catalog	Research Areas >> Others Signaling Pathways >> Anti-infection >> Bacterial
References	[1]. Pearson JP, Gray KM, Passador L, Tucker KD, Eberhard A, Iglewski BH, Greenberg EP. Structure of the autoinducer required for expression of Pseudomonas aeruginosa virulence genes. Proc Natl Acad Sci U S A. 1994 Jan 4;91(1):197-201. [2]. Chambers CE, Visser MB, Schwab U, Sokol PA. Identification of N-acylhomoserine lactones in mucopurulent respiratory secretions from cystic fibrosis patients. FEMS Microbiol Lett. 2005 Mar 15;244(2):297-304. [3]. Smith RS, Fedyk ER, Springer TA, Mukaida N, Iglewski BH, Phipps RP. IL-8 production in human lung fibroblasts and epithelial cells activated by the Pseudomonas autoinducer N-3-oxododecanoyl homoserine lactone is transcriptionally regulated by NF-kappa B a

Hazard Codes	Xn
HS Code	2932209090

HS Code	2932209090
Summary	2932209090. other lactones. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%