2304-81-6

2304-81-6 structure

Name: C18 CERAMIDE
Chemical Name: c18 ceramide
CAS Number: 2304-81-6
Molecular Formula: C₃₆H₇₁NO₃
Molecular Weight: 565.95400
Catalog: Chemical reagent Organic reagent Fatty alcohol
Create Date: 2018-04-09 08:00:00
Modify Date: 2024-01-21 09:25:38
C18-Ceramide can promote exocytosis of glutamate from damaged neurons. C18-Ceramide promotes cell death in glioma cells. Ceramides is involved in diverse cellular functions, such as differentiation, cell cycle progression, cell-cell adhesion, senescence, and apoptosis[1].

Name	c18 ceramide
Synonyms	STEAROYL CERAMIDE ceramide c18 N-((2S,3R,E)-1,3-dihydroxyoctadec-4-en-2-yl)stearamide N-Stearoyl-D-erythro-sphingosine N-stearoylsphingosine Cer(d18:1/18:0) N-STEAROYLSPHINGANINE C18 DIHYDROCERAMIDE N-(octadecanoyl)-sphing-4-enine N-18:0 SPHINGANINE C18-D-ERYTHRO-CERAMIDE N-stearoyl-D-erythro-sphingosine N-Stearoyl-D-sphingosine 18:0 CERAMIDE N-((2S,3R,4E)-1,3-dihydroxyoctadec-4-en-2-yl)stearamide (2S,3R,4E)-2-(N-stearoylamino)-4-octadecene-1,3-diol N-STEAROYL CERAMIDE

Description	C18-Ceramide can promote exocytosis of glutamate from damaged neurons. C18-Ceramide promotes cell death in glioma cells. Ceramides is involved in diverse cellular functions, such as differentiation, cell cycle progression, cell-cell adhesion, senescence, and apoptosis[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease
References	[1]. Tang N, et al. Differential effects of ceramide species on exocytosis in rat PC12 cells. Exp Brain Res. 2007 Nov;183(2):241-7. [2]. Wang Z, et al. Overexpression of ceramide synthase 1 increases C18-ceramide and leads to lethal autophagy in human glioma. Oncotarget. 2017 Oct 23;8(61):104022-104036.

Density	0.915g/cm3
Boiling Point	694.5ºC at 760 mmHg
Melting Point	99 - 101ºC
Molecular Formula	C₃₆H₇₁NO₃
Molecular Weight	565.95400
Flash Point	373.8ºC
Exact Mass	565.54300
PSA	69.56000
LogP	10.73410
Vapour Pressure	2.59E-22mmHg at 25°C
Index of Refraction	1.479
Storage condition	−20°C
Stability	Stable, but may be heat sensitive - store below 4 C. Incompatible with strong oxidizing agents.

Name:	N-Stearoyl-D-erythro-spinghosine synthetical 99+% Material Safety Data Sheet
Synonym:	Ceramide C1
CAS:	2304-81-6

Section 1 - Chemical Product MSDS Name:N-Stearoyl-D-erythro-spinghosine synthetical 99+% Material Safety Data Sheet
Synonym:Ceramide C1

Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS

CAS#	Chemical Name	content	EINECS#
2304-81-6	N-Stearoyl-D-erythro-spinghosine, synt	99+%	unlisted

Hazard Symbols: None Listed.
Risk Phrases: None Listed.

Section 3 - HAZARDS IDENTIFICATION

EMERGENCY OVERVIEW
Not available.
Potential Health Effects
Eye:
May cause eye irritation.
Skin:
May cause skin irritation.
Ingestion:
May cause irritation of the digestive tract. The toxicological properties of this substance have not been fully investigated.
Inhalation:
May cause respiratory tract irritation.
Chronic:
Not available.

Section 4 - FIRST AID MEASURES
Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.
Skin:
Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes.
Ingestion:
Get medical aid. Wash mouth out with water.
Inhalation:
Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
Notes to Physician:

Section 5 - FIRE FIGHTING MEASURES
General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear.
Extinguishing Media:
Use extinguishing media most appropriate for the surrounding fire.

Section 6 - ACCIDENTAL RELEASE MEASURES
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Vacuum or sweep up material and place into a suitable disposal container.

Section 7 - HANDLING and STORAGE
Handling:
Avoid breathing dust, vapor, mist, or gas. Avoid contact with skin and eyes.
Storage:
Store in a tightly closed container. Deep freeze (below -20C). Keep refrigerated. (Store below 4C/39F.)

Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
Engineering Controls:
Use adequate ventilation to keep airborne concentrations low.
Exposure Limits CAS# 2304-81-6: Personal Protective Equipment Eyes: Not available.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.

Section 9 - PHYSICAL AND CHEMICAL PROPERTIES

Physical State: Powder
Color: white
Odor: Not available.
pH: Not available.
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: Not available.
Freezing/Melting Point: 99 - 101 deg C
Autoignition Temperature: Not available.
Flash Point: Not available.
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature:
Solubility in water: insoluble
Specific Gravity/Density:
Molecular Formula:
Molecular Weight: 565.96

Section 10 - STABILITY AND REACTIVITY
Chemical Stability:
Not available.
Conditions to Avoid:
Incompatible materials.
Incompatibilities with Other Materials:
Strong oxidizing agents.
Hazardous Decomposition Products:
Carbon monoxide, oxides of nitrogen, carbon dioxide.
Hazardous Polymerization: Has not been reported

Section 11 - TOXICOLOGICAL INFORMATION
RTECS#:
CAS# 2304-81-6 unlisted.
LD50/LC50:
Not available.
Carcinogenicity:
N-Stearoyl-D-erythro-spinghosine, synthetical - Not listed by ACGIH, IARC, or NTP.

Section 12 - ECOLOGICAL INFORMATION

Section 13 - DISPOSAL CONSIDERATIONS
Dispose of in a manner consistent with federal, state, and local regulations.

Section 14 - TRANSPORT INFORMATION

IATA
Shipping Name: Not regulated.
Hazard Class:
UN Number:
Packing Group:
IMO
Shipping Name: Not regulated.
Hazard Class:
UN Number:
Packing Group:
RID/ADR
Shipping Name: Not regulated.
Hazard Class:
UN Number:
Packing group:

Section 15 - REGULATORY INFORMATION

European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: Not available.
Risk Phrases:
Safety Phrases:
S 24/25 Avoid contact with skin and eyes.
WGK (Water Danger/Protection)
CAS# 2304-81-6: No information available.
Canada
None of the chemicals in this product are listed on the DSL/NDSL list.
CAS# 2304-81-6 is not listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 2304-81-6 is not listed on the TSCA inventory.
It is for research and development use only.

SECTION 16 - ADDITIONAL INFORMATION
N/A

Safety Phrases	S24/25
HS Code	29225000

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