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555-57-7 306-07-0
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555-57-7

555-57-7 structure
555-57-7 structure
  • Name: Pargyline
  • Chemical Name: N-Methyl-N-propargylbenzylamine
  • CAS Number: 555-57-7
  • Molecular Formula: C11H13N
  • Molecular Weight: 159.22800
  • Catalog: API Circulatory system medication Antihypertensive drug
  • Create Date: 2018-05-13 08:00:00
  • Modify Date: 2024-01-09 18:37:37
  • Pargyline is an irreversible non-selective monoamine oxidase (MAO) inhibitor drug (IC50 for MAO-A is 11.52 nM and for MAO-B is 8.2 nM) .
Name N-Methyl-N-propargylbenzylamine
Synonyms EINECS 209-101-6
N-benzyl-N-methylprop-2-yn-1-amine
MFCD00008576
Pargyline
Description Pargyline is an irreversible non-selective monoamine oxidase (MAO) inhibitor drug (IC50 for MAO-A is 11.52 nM and for MAO-B is 8.2 nM) .
Related Catalog
Density 0.94
Boiling Point 86-88ºC(4 torr)
Melting Point 156 - 160ºC
Molecular Formula C11H13N
Molecular Weight 159.22800
Flash Point 83ºC
Exact Mass 159.10500
PSA 3.24000
LogP 1.75160
Index of Refraction n20/D 1.522(lit.)

CHEMICAL IDENTIFICATION

RTECS NUMBER :
DP6475000
CHEMICAL NAME :
Benzylamine, N-methyl-N-2-propynyl-
CAS REGISTRY NUMBER :
555-57-7
BEILSTEIN REFERENCE NO. :
1938132
LAST UPDATED :
199612
DATA ITEMS CITED :
10
MOLECULAR FORMULA :
C11-H13-N
MOLECULAR WEIGHT :
159.25
WISWESSER LINE NOTATION :
1UU2N1&1R

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human - child
DOSE/DURATION :
8750 ug/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Olfaction) - effect, not otherwise specified Sense Organs and Special Senses (Eye) - lacrimation Lungs, Thorax, or Respiration - other changes
REFERENCE :
34ZIAG "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969 Volume(issue)/page/year: -,452,1969
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
300 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 14,913,1971
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
680 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 14,913,1971
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
290 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
THERAP Therapie. (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris, France) V.1- 1946- Volume(issue)/page/year: 22,367,1967
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
380 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958- Volume(issue)/page/year: 17,369,1968
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
56 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#02420 ** REPRODUCTIVE DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
DOSE :
180 mg/kg
SEX/DURATION :
male 12 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - testes, epididymis, sperm duct Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland, accessory glands
REFERENCE :
FESTAS Fertility and Sterility. (American Fertility Soc., 608 13th Ave. S, Birmingham, AL 35282) V.1- 1950- Volume(issue)/page/year: 27,1326,1976
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Implant
DOSE :
100 mg/kg
SEX/DURATION :
male 21 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - testes, epididymis, sperm duct Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland, accessory glands
REFERENCE :
FESTAS Fertility and Sterility. (American Fertility Soc., 608 13th Ave. S, Birmingham, AL 35282) V.1- 1950- Volume(issue)/page/year: 27,1326,1976
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intratesticular
DOSE :
138 mg/kg
SEX/DURATION :
male 21 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - testes, epididymis, sperm duct
REFERENCE :
FESTAS Fertility and Sterility. (American Fertility Soc., 608 13th Ave. S, Birmingham, AL 35282) V.1- 1950- Volume(issue)/page/year: 27,1326,1976
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intratesticular
DOSE :
200 mg/kg
SEX/DURATION :
male 21 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland, accessory glands
REFERENCE :
FESTAS Fertility and Sterility. (American Fertility Soc., 608 13th Ave. S, Birmingham, AL 35282) V.1- 1950- Volume(issue)/page/year: 27,1326,1976
Hazard Codes Xn:Harmful;
Risk Phrases R22
Safety Phrases S23
RIDADR UN 2810 6.1/PG 3
WGK Germany 3
RTECS DP6475000
Packaging Group III
Hazard Class 6.1(b)
106-96-7 structure

106-96-7

103-67-3 structure

103-67-3

~85%

555-57-7 structure

555-57-7

Literature: Crock, Piero Dalla; Ferraccioli, Raffaella; Rosa, Concetta L.A. Gazzetta Chimica Italiana, 1996 , vol. 126, # 2 p. 107 - 109
103-67-3 structure

103-67-3

~%

555-57-7 structure

555-57-7

Literature: Justus Liebigs Annalen der Chemie, , vol. 445, p. 207 Justus Liebigs Annalen der Chemie, , vol. 449, p. 258
35161-71-8 structure

35161-71-8

100-52-7 structure

100-52-7

~%

555-57-7 structure

555-57-7

Literature: Journal of Pharmacy and Pharmacology, , vol. 43, # 11 p. 750 - 757
111831-90-4 structure

111831-90-4

~%

555-57-7 structure

555-57-7

Literature: Justus Liebigs Annalen der Chemie, , vol. 445, p. 207 Justus Liebigs Annalen der Chemie, , vol. 449, p. 258
62505-91-3 structure

62505-91-3

~%

555-57-7 structure

555-57-7

Literature: The Journal of organic chemistry, , vol. 42, # 15 p. 2637 - 2637

Chemsrc provides CAS#:555-57-7 MSDS, density, melting point, boiling point, structure, formula, molecular weight, synthetic route, etc.
title: CAS No. 555-57-7 | Chemsrc address: https://m.chemsrc.com/en/baike/586153.html

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