Pargyline

Modify Date: 2026-08-02 08:13:59

Pargyline structure	Common Name	Pargyline
	CAS Number	555-57-7	Molecular Weight	159.22800
	Density	0.94	Boiling Point	86-88ºC(4 torr)
	Molecular Formula	C₁₁H₁₃N	Melting Point	156 - 160ºC
	MSDS	N/A	Flash Point	83ºC

Use of Pargyline

Pargyline is an irreversible non-selective monoamine oxidase (MAO) inhibitor drug (IC50 for MAO-A is 11.52 nM and for MAO-B is 8.2 nM) .

This table lists Chinese names, IUPAC names and various aliases of this chemical substance.

Name	N-Methyl-N-propargylbenzylamine
Synonym	More Synonyms

This table contains bioactivity, target information and biological‑assay experimental data of this compound.

Description	Pargyline is an irreversible non-selective monoamine oxidase (MAO) inhibitor drug (IC50 for MAO-A is 11.52 nM and for MAO-B is 8.2 nM) .
Related Catalog	Signaling Pathways >> Neuronal Signaling >> Monoamine Oxidase Research Areas >> Neurological Disease

This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.

Density	0.94
Boiling Point	86-88ºC(4 torr)
Melting Point	156 - 160ºC
Molecular Formula	C₁₁H₁₃N
Molecular Weight	159.22800
Flash Point	83ºC
Exact Mass	159.10500
PSA	3.24000
LogP	1.75160
Index of Refraction	n20/D 1.522(lit.)
InChIKey	DPWPWRLQFGFJFI-UHFFFAOYSA-N
SMILES	C#CCN(C)Cc1ccccc1

This table provides MSDS information including hazard classification, first‑aid, fire‑fighting, spill handling, operation and storage instructions.

Pargyline MSDS(Chinese)

This table summarizes toxicological test data, acute & chronic toxicity and ecological hazard parameters for this chemical.

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DP6475000

CHEMICAL NAME :: Benzylamine, N-methyl-N-2-propynyl-

CAS REGISTRY NUMBER :: 555-57-7

BEILSTEIN REFERENCE NO. :: 1938132

LAST UPDATED :: 199612

DATA ITEMS CITED :: 10

MOLECULAR FORMULA :: C11-H13-N

MOLECULAR WEIGHT :: 159.25

WISWESSER LINE NOTATION :: 1UU2N1&1R

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - child

DOSE/DURATION :: 8750 ug/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Olfaction) - effect, not otherwise specified Sense Organs and Special Senses (Eye) - lacrimation Lungs, Thorax, or Respiration - other changes

REFERENCE :: 34ZIAG "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969 Volume(issue)/page/year: -,452,1969

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 300 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 14,913,1971

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 680 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 14,913,1971

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 290 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: THERAP Therapie. (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris, France) V.1- 1946- Volume(issue)/page/year: 22,367,1967

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 380 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958- Volume(issue)/page/year: 17,369,1968

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 56 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#02420 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 180 mg/kg

SEX/DURATION :: male 12 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - testes, epididymis, sperm duct Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland, accessory glands

REFERENCE :: FESTAS Fertility and Sterility. (American Fertility Soc., 608 13th Ave. S, Birmingham, AL 35282) V.1- 1950- Volume(issue)/page/year: 27,1326,1976

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Implant

DOSE :: 100 mg/kg

SEX/DURATION :: male 21 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - testes, epididymis, sperm duct Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland, accessory glands

REFERENCE :: FESTAS Fertility and Sterility. (American Fertility Soc., 608 13th Ave. S, Birmingham, AL 35282) V.1- 1950- Volume(issue)/page/year: 27,1326,1976

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intratesticular

DOSE :: 138 mg/kg

SEX/DURATION :: male 21 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - testes, epididymis, sperm duct

REFERENCE :: FESTAS Fertility and Sterility. (American Fertility Soc., 608 13th Ave. S, Birmingham, AL 35282) V.1- 1950- Volume(issue)/page/year: 27,1326,1976

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intratesticular

DOSE :: 200 mg/kg

SEX/DURATION :: male 21 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland, accessory glands

REFERENCE :: FESTAS Fertility and Sterility. (American Fertility Soc., 608 13th Ave. S, Birmingham, AL 35282) V.1- 1950- Volume(issue)/page/year: 27,1326,1976

This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.

Hazard Codes	Xn:Harmful;
Risk Phrases	R22
Safety Phrases	S23
RIDADR	UN 2810 6.1/PG 3
WGK Germany	3
RTECS	DP6475000
Packaging Group	III
Hazard Class	6.1(b)

This table presents publicly reported synthetic routes, reaction conditions, reactants and product information of the compound.

3-Bromopropyne

CAS#:106-96-7

N-Methylbenzylamine

CAS#:103-67-3

~85%

Pargyline

CAS#:555-57-7

Learn More

Literature: Crock, Piero Dalla; Ferraccioli, Raffaella; Rosa, Concetta L.A. Gazzetta Chimica Italiana, 1996 , vol. 126, # 2 p. 107 - 109

N-Methylbenzylamine

CAS#:103-67-3

Pargyline

CAS#:555-57-7

Learn More

Literature: Justus Liebigs Annalen der Chemie, , vol. 445, p. 207 Justus Liebigs Annalen der Chemie, , vol. 449, p. 258

N-Methylproparg...

CAS#:35161-71-8

Benzaldehyde

CAS#:100-52-7

Pargyline

CAS#:555-57-7

Learn More

Literature: Journal of Pharmacy and Pharmacology, , vol. 43, # 11 p. 750 - 757

N-Benzyl-2-brom...

CAS#:111831-90-4

Pargyline

CAS#:555-57-7

Learn More

Literature: Justus Liebigs Annalen der Chemie, , vol. 445, p. 207 Justus Liebigs Annalen der Chemie, , vol. 449, p. 258

5-[benzyl(methy...

CAS#:62505-91-3

Pargyline

CAS#:555-57-7

Learn More

Literature: The Journal of organic chemistry, , vol. 42, # 15 p. 2637 - 2637

This table lists upstream starting materials and downstream derivative products related to this chemical.

Precursor 6
CAS#:106-96-7 3-Bromopropyne CAS#:103-67-3 N-Methylbenzylamine CAS#:35161-71-8 N-Methylproparg... CAS#:100-52-7 Benzaldehyde
CAS#:111831-90-4 N-Benzyl-2-brom... CAS#:62505-91-3 5-[benzyl(methy...
DownStream 3
CAS#:622-29-7 N-Benzylideneme... CAS#:1197-51-9 Benzenemethanam... CAS#:100-52-7 Benzaldehyde

This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.

EINECS 209-101-6

N-benzyl-N-methylprop-2-yn-1-amine

MFCD00008576

Pargyline

This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.

Q: What English synonyms does N-Methyl-N-propargylbenzylamine have?

A: English synonyms of N-Methyl-N-propargylbenzylamine: EINECS 209-101-6, N-benzyl-N-methylprop-2-yn-1-amine, MFCD00008576, Pargyline.

Q: What are the downstream products of N-Methyl-N-propargylbenzylamine?

A: Related downstream products(CAS) of N-Methyl-N-propargylbenzylamine: 622-29-7;1197-51-9;100-52-7.

Q: What is the molecular formula of N-Methyl-N-propargylbenzylamine?

A: Molecular formula of N-Methyl-N-propargylbenzylamine is C11H13N.

Q: What is the polar surface area (PSA) of N-Methyl-N-propargylbenzylamine?

A: Polar surface area (PSA) of N-Methyl-N-propargylbenzylamine is 3.24000.

Q: What is the InChIKey of N-Methyl-N-propargylbenzylamine?

A: InChIKey of N-Methyl-N-propargylbenzylamine is DPWPWRLQFGFJFI-UHFFFAOYSA-N.

Q: What is the melting point of N-Methyl-N-propargylbenzylamine?

A: Melting point of N-Methyl-N-propargylbenzylamine is 156 - 160ºC.

Q: What is the LogP of N-Methyl-N-propargylbenzylamine?

A: LogP of N-Methyl-N-propargylbenzylamine is 1.75160.

Q: What are the uses of N-Methyl-N-propargylbenzylamine?

A: Main uses of N-Methyl-N-propargylbenzylamine: Pargyline is an irreversible non-selective monoamine oxidase (MAO) inhibitor drug (IC50 for MAO-A is 11.52 nM and for MAO-B is 8.2 nM) .

Q: What are the upstream materials of N-Methyl-N-propargylbenzylamine?

A: Related upstream materials(CAS) of N-Methyl-N-propargylbenzylamine: 106-96-7;103-67-3;35161-71-8;100-52-7;111831-90-4;62505-91-3.

Q: What is the SMILES notation of N-Methyl-N-propargylbenzylamine?

A: SMILES notation of N-Methyl-N-propargylbenzylamine is C#CCN(C)Cc1ccccc1.

This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.

Shanghai Nianxing Industrial Co., Ltd

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Pargyline
Price: Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

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Pargyline suppliers

Price: $60/500mg

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Pargyline

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Pargyline Biological Activity

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The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.