14919-77-8
14919-77-8 structure
- Name: Benserazide hydrochloride
- Chemical Name: benserazide hydrochloride
- CAS Number: 14919-77-8
- Molecular Formula: C10H16ClN3O5
- Molecular Weight: 293.704
- Catalog: API Nervous system medication Anti-shock palsy
- Create Date: 2018-03-18 08:00:00
- Modify Date: 2026-06-30 15:24:37
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Benserazide Hydrochloride is a peripherally-acting aromatic L-amino acid decarboxylase (AAAD) or DOPA decarboxylase inhibitor.Target: DOPA decarboxylaseBenserazide is commonly used for Parkinson's disease in combination with L-DOPA as a peripheral aromatic L-amino acid decarboxylase (AADC) inhibitor. Administration of 5, 10 and 50 mg/kg benserazide to 6-OHDA-lesioned rats showed an identical increase in exogenous L-DOPA-derived extracellular DA levels, the time to reach the peak DA levels were significantly prolonged by benserazide dose-dependently. The AADC activity in the denervated striatal tissues showed a significant decrease by 10 mg/kg and 50 mg/kg benserazide. These results suggest that benserazide reduces the central AADC activity in the striatum of rats with nigrostriatal denervation, which leads to changes in the metabolism of exogenous L-DOPA [1].
| Name | benserazide hydrochloride |
|---|---|
| Synonyms |
Benzhydrazine hydrochloride
Benserazide HCl - Bio-X NC00093 Benserazide hydrochloride (Serazide) Ro 4-4602 Benserazide hydrochloride //BP Benserazide hydrochloride-D3 Benserazide HCl BENPIZDE Benserazide Hydrochloride Benserazide hydrochioride Benserazide hydrochlo Benserazide hydrochloride(Benserazide HCl) 31-6 BENSERAZIDE HYDROCHLORIDE PERIPHERAL D 2-Amino-3-hydroxy-N'-(2,3,4-trihydroxybenzyl)propanehydrazide hydrochloride (1:1) (non-preferred name) MFCD00078571 DL-SERINE 2[(2,3,4-TRIHYDROXYPHENYL)-METHYL] HYDRAZIDE HYDROCHLORIDE DL-Serine 2-(2,3,4-trihydroxybenzyl)hydrazide hydrochloride Benserazide Hydrochloride > BENSERAZIDE HYDROCHLORIDE EP2000 Benserazid hydrochloride BENPARIZDE RO 2 Benzyserazine hydrochloride N'-(2,3,4-Trihydroxybenzyl)-(2S)-Benserazide-d3 BENSERAZIDE HYDROCHLORIDE \ PERIPHERAL D Benserazide DL-SERINE 2-[(2,3,4-TRIHYDROXYPHENYL)METHYL]HYDRAZIDE HCL 2-(2,3,4-TRIHYDROXYBENZYL)HYDRAZIDE Ro 2/001 N-(DL-Seryl)-N'-(2,3,4-trihydroxybenzyl)hydrazine hydrochloride Benserazide HCl (Ro 2) Serine, 2-(2,3,4-trihydroxybenzyl)hydrazide, monohydrochloride (8CI) Benserazide (hydrochloride) DL-Serine N2-(2,3,4-trihydroxybenzyl)hydrazide hydrochloride (2RS)-2-Amino-3-hydroxy-2′-(2,3,4-trihydroxybenzyl)propanohydrazide hydrochloride Madopa (Hoffmann-Loche) SPECTRUM1500137 Benserazide HCl (Serazide) N'-(DL-Seryl)-N''-(2,3,4-trihydroxybenzyl)hydrazine hydrochloride EINECS 238-991-9 D3- Benserazide Hydrochloride N'-(2,3,4-trihydroxybenzyl)-2-amino-3-hydroxypropanehydrazide, hydrochloride(1:1) Benserazide for peak identification CRS 2-(2,3,4-trihydroxybenzyl)hydrazide,monohydrochloride,dl-serin Ro 4-4602/001 2'-(2,3,4-trihydroxybenzyl)-dl-serinohydrazide monohydrochloride dl-serine 2-(2,3,4-trihydroxybenzyl)hydrazide hydrochloride Benserazide hydrochloride CRS Benserazide HCI 2-amino-3-hydroxy-N'-(2,3,4-trihydroxybenzyl)propanohydrazide hydrochloride Benserazide HydrochlorideQ: What is Benserazide Hydrochloride Q: What is the CAS Number of Benserazide Hydrochloride Q: What is the storage condition of Benserazide Hydrochloride Q: What e the applications of Benserazide Hydrochloride BENSERAZIDE HYDROCHLORIDE 2000 Benserazide D3 HydrochlorideQ: What is Benserazide D3 Hydrochloride Q: What is the CAS Number of Benserazide D3 Hydrochloride Q: What is the storage condition of Benserazide D3 Hydrochloride Q: What e the applications of Benserazide D3 Hydrochloride Benserazide hydrochloride peripherally acting DOPA decboxylase inhibitor Serine, 2-[(2,3,4-trihydroxyphenyl)methyl]hydrazide, hydrochloride (1:1) dl-serine2-(2,3,4-trihydroxybenzyl)hydrazinehydrochloride BENSERAZIDE HCL dl-serine,2-((2,3,4-trihydroxyphenyl)methyl)hydrazide,monohydrochloride Serine, 2-[(2,3,4-trihydroxyphenyl)methyl]hydrazide, monohydrochloride (S)-2-Amino-3-hydroxy-N'-(2,3,4-trihydroxybenzyl)propanehydrazide hydrochloride 2-Amino-3-hydroxy-N'-(2,3,4-trihydroxybenzyl)propanehydrazide hydrochloride |
| Description | Benserazide Hydrochloride is a peripherally-acting aromatic L-amino acid decarboxylase (AAAD) or DOPA decarboxylase inhibitor.Target: DOPA decarboxylaseBenserazide is commonly used for Parkinson's disease in combination with L-DOPA as a peripheral aromatic L-amino acid decarboxylase (AADC) inhibitor. Administration of 5, 10 and 50 mg/kg benserazide to 6-OHDA-lesioned rats showed an identical increase in exogenous L-DOPA-derived extracellular DA levels, the time to reach the peak DA levels were significantly prolonged by benserazide dose-dependently. The AADC activity in the denervated striatal tissues showed a significant decrease by 10 mg/kg and 50 mg/kg benserazide. These results suggest that benserazide reduces the central AADC activity in the striatum of rats with nigrostriatal denervation, which leads to changes in the metabolism of exogenous L-DOPA [1]. |
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| Related Catalog | |
| References |
| Boiling Point | 574.2ºC at 760 mmHg |
|---|---|
| Melting Point | 146°C |
| Molecular Formula | C10H16ClN3O5 |
| Molecular Weight | 293.704 |
| Exact Mass | 293.077850 |
| PSA | 148.07000 |
| LogP | 0.52790 |
| Storage condition | -20°C Freezer |
| Water Solubility | H2O: 10 mg/mL |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
MUTATION DATA
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| Symbol |
GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H315-H319-H335 |
| Precautionary Statements | P305 + P351 + P338 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
| Hazard Codes | Xi |
| Risk Phrases | R36/37/38 |
| Safety Phrases | S26-S36 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 2 |
| RTECS | VT9632300 |
| HS Code | 2928000090 |
| HS Code | 2928000090 |
|---|---|
| Summary | 2928000090 other organic derivatives of hydrazine or of hydroxylamine VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0% |