1071-37-0
1071-37-0 structure
- Name: Ethyl carbamimidothioate hydrobromide (1:1)
- Chemical Name: ethyl carbamimidothioate,hydrobromide
- CAS Number: 1071-37-0
- Molecular Formula: C3H9BrN2S
- Molecular Weight: 185.09
- Catalog: Chemical reagent Organic reagent Thiourea
- Create Date: 2018-06-27 18:24:43
- Modify Date: 2024-01-08 23:19:36
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S-EIT (hydrobromide) is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
| Name | ethyl carbamimidothioate,hydrobromide |
|---|---|
| Synonyms |
MFCD00012585
Ethiron S-ethylisothiouronium hydrobromate S-Ethylisothio Urea,Hydrobromide Ethyl carbamimidothioate hydrobromide (1:1) Ethiron bromide USAF EL-18 S-ethylthiouronium bromide 2-Ethyl-2-isothiourea hydrobromide S-Ethylisothiuronium bromide S-Ethylthiuronium bromide 2-Ethyl-2-thiopseudourea hydrobromide 2-ethyl isothiourea hydrobromide Carbamimidothioic acid, ethyl ester, hydrobromide (1:1) Bromide S-ethylisothiuronium etiron S-Ethylisothiouronium hydrobromide ethyl imidothiocarbamate hydrobromide S-ETHYLISOTHIOUREA HYDROBROMIDE |
| Description | S-EIT (hydrobromide) is a biochemical reagent that can be used as a biological material or organic compound for life science related research. |
|---|---|
| Related Catalog | |
| In Vitro | EIT (S-ethylisothiourea) Hydrobromide 是 II 型 NOS 的选择性抑制剂。EIT 对 LPS 诱导的血浆 [NOx] 增加产生剂量依赖性和 > 95% 的抑制。EIT 的 ED50 值为 0.4 mg/kg。用 L-精氨酸（但不是 D-精氨酸）预处理可防止死亡率，同时不影响 II 型 NOS 依赖性 NO 的产生，表明毒性可能是由于抑制其他 NOS 亚型（内皮或神经元）之一 [1 ].选择性 NOS II 拮抗剂减弱但不阻断胎儿肺中剪切应力诱导的血管舒张。NOS II 活性的刺激（可能来自平滑肌细胞）在剪切应力诱导的肺血管舒张过程中部分促成了 NO 介导的 PVR（肺血管阻力）下降。在存在 AMT 或另一种选择性 iNOS 抑制剂 S-乙基异硫脲 (EIT) 的情况下用同种异体抗原刺激的脾细胞比在没有 iNOS 抑制剂的情况下刺激的细胞产生更多的白细胞介素 (IL)-4 和 IL-10。Th1 细胞因子 IL-2 和干扰素 (IFN)-γ 的产生并未因抑制 NO 合成而增强 。急性给予 EIT (380 nmol/h)，另一种诱导型一氧化氮合酶选择性抑制剂，也减弱了妊娠引起的肾小球滤过率和有效肾血浆流量的增加。 |
| Density | 1.19 g/cm3 |
|---|---|
| Boiling Point | 159.6ºC at 760 mmHg |
| Melting Point | 79-81°C |
| Molecular Formula | C3H9BrN2S |
| Molecular Weight | 185.09 |
| Flash Point | 50.3ºC |
| Exact Mass | 183.966980 |
| PSA | 75.17000 |
| LogP | 2.39110 |
| Vapour Pressure | 2.26mmHg at 25°C |
| Index of Refraction | 1.548 |
| Storage condition | 2-8°C |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
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| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| Risk Phrases | R22 |
| Safety Phrases | S22-S36/37 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| RTECS | UM6825000 |
| HS Code | 2930909090 |
|
~99%
1071-37-0 |
| Literature: PROGENICS PHARMACEUTICALS, INC.; HAN, Amy, Qi; WANG, Eric; GAUSS, Carla; XIE, Walter; COBURN, Glen; DEMUYS, Jean-Marc Patent: WO2010/118367 A2, 2010 ; Location in patent: Page/Page column 78 ; |
| Precursor 1 | |
|---|---|
| DownStream 10 | |
![1-[2-(Diphenylmethoxy)ethyl]guanidine structure](https://image.chemsrc.com/caspic/062/16136-32-6.png)
| HS Code | 2930909090 |
|---|---|
| Summary | 2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |