16502-01-5
16502-01-5 structure
- Name: Tryptoline
- Chemical Name: 1,2,3,4-tetrahydro-9h-pyrido[3,4-b]indole
- CAS Number: 16502-01-5
- Molecular Formula: C11H12N2
- Molecular Weight: 172.226
- Catalog: Signaling Pathways GPCR/G Protein 5-HT Receptor
- Create Date: 2018-12-28 09:28:08
- Modify Date: 2026-06-30 21:17:28
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Tetrahydro-β-carboline (Tryptoline) is a metabolite of tryptamine, also is a competitive serotonin reuptake inhibitor with an Ki value of 6.1 µM[1].
| Name | 1,2,3,4-tetrahydro-9h-pyrido[3,4-b]indole |
|---|---|
| Synonyms |
1,2,3,4-TETRAHYDRO-BETA-CBOLINE
2,3,4,9-Tetrahydro-1H-b-cboline 1,2,3,4-Tetrahydro-9H-Pyrido[3,4-B]Indole Tetrahydro-beta-carboline NORELEAGNINE Tetrahydro-β-cboline H-Pyrido[3,4-b]indole, 2,3,4,9-tetrahydro 1,2,3,4-Tetrahydro-9H-pyrido[3,4-b]indole, Noreleagnine, Tetrahydronorhman, THBC, Tryptoline 1,2,3,4-tetrahydro-9H-pyridino [3,4-b] indole 1,2,3,4-Tetrahydro-9H-pyrido[3,4-b]indole,1,2,3,4-Tetrahydro-β-cboline, 2,3,4,9-Tetrahydro-1H-pyrido(3,4-b)indole, Tetrahydronorhmane, Tryptoline 2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole TRYPTOLINE 1,2,3,4-Tetrahydro-9H-pyrido[3,4-b]indole TETRAHYDRONORHMAN Triptoline 4-B]INDOLE 1H-Pyrido[3,4-b]indole,2,3,4,9-tetrahydro 2,3,4,9-Tetrahydro-1H-β-cboline 2,3,4,9-Tetrahydro-1H-β-carboline Tetrahydro-b-carboline Tetrahydro-β-carboline 1,2,3,4-Tetrahydro-9H-pyrido[3,4-b]indole-13C,d2 2,3,4,9-TETRAHYDRO-1H-BETA-CBOLINE 1H,2H,3H,4H,9H-pyrido[3,4-b]indole 1,2,3,4-Tetrahydro-b-carboline 1,2,3,4-Tetrahydro-β-cboline, 2,3,4,9-Tetrahydro-1H-pyrido(3,4-b)indole, Tetrahydronorhmane, Tryptoline 1,2,3,4-TetrahydronorhMan 1,2,3,4-Tetrahydro-β-cboline 2,3,4,9-TETRAHYDRO-1H-PYRIDO[3,4-B]INDOLE TETRAHYDRONORHMANE 1,2,3,4-TETRAHYDRO-B-CBOLINE 2,3,4,9-tetrahydro-1H-beta-cboline hydrochloride Norhman,1,2,3,4-tetrahydro MFCD00004954 TETRAHYDRO-BETA-CBOLINE Noreleaginine |
| Description | Tetrahydro-β-carboline (Tryptoline) is a metabolite of tryptamine, also is a competitive serotonin reuptake inhibitor with an Ki value of 6.1 µM[1]. |
|---|---|
| Related Catalog | |
| Target |
serotonin:6.1 μM (Ki) |
| In Vivo | Tetrahydro-β-carboline (20 µg; i.c.v.) increases the serotonin levels in the same part of the brain in rats[1]. Animal Model: 180-200g female Sprague-Dawley rats[1] Dosage: 20 µg Administration: Intraventricular injection Result: Increased of serotonin levels in the same part of the brain whereas the monoamine oxidase activity was not altered. |
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 351.6±32.0 °C at 760 mmHg |
| Melting Point | 206-208 °C(lit.) |
| Molecular Formula | C11H12N2 |
| Molecular Weight | 172.226 |
| Flash Point | 166.5±25.1 °C |
| Exact Mass | 172.100052 |
| PSA | 27.82000 |
| LogP | 1.33 |
| Vapour Pressure | 0.0±0.8 mmHg at 25°C |
| Index of Refraction | 1.670 |
| Storage condition | Refrigerator |
| Symbol |
GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H315-H319-H335 |
| Precautionary Statements | P261-P305 + P351 + P338 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
| Hazard Codes | Xi: Irritant; |
| Risk Phrases | R36/37/38 |
| Safety Phrases | S26-S36 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| HS Code | 2933990090 |
| Precursor 9 | |
|---|---|
| DownStream 10 | |
![1-phenyl-2-(1,3,4,9-tetrahydropyrido[3,4-b]indol-2-yl)ethanone structure](https://image.chemsrc.com/caspic/288/111733-93-8.png)
![7-Nitro-1,2,3,4-tetrahydro-9H-pyrido[3,4-b]indole structure](https://image.chemsrc.com/caspic/196/642412-39-3.png)
![TERT-BUTYL 3,4-DIHYDRO-1H-PYRIDO[3,4-B]INDOLE-2(9H)-CARBOXYLATE structure](https://image.chemsrc.com/caspic/168/168824-94-0.png)
![1,2,3,4-TETRAHYDRO-9-(PHENYLMETHYL)-PYRIDO[3,4-B]INDOLE structure](https://image.chemsrc.com/caspic/131/134331-71-8.png)
![9-Methyl-9H-Pyrido[3,4-b]indole hydrochloride structure](https://image.chemsrc.com/caspic/196/752213-27-7.png)
| HS Code | 2933990090 |
|---|---|
| Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |