103429-32-9

103429-32-9 structure

Name: H-D-Phe-Cys-Tyr-D-Trp-Arg-Thr-Pen-Thr-NH2 (Disulfide bond between Cys2 and Pen7)
Chemical Name: ctap
CAS Number: 103429-32-9
Molecular Formula: C₅₁H₆₉N₁₃O₁₁S₂
Molecular Weight: 1104.304
Catalog: Signaling Pathways GPCR/G Protein Opioid Receptor
Create Date: 2018-12-28 21:02:18
Modify Date: 2026-07-09 10:45:11
CTAP is a potent, highly selective, and brain penetrant μ opioid receptor antagonist (IC50=3.5 nM) and displays over 1200-fold selectivity over δ opioid (IC50=4500 nM) and somatostatin receptors. CTAP can be used for the study of L-DOPA-induced dyskinesia (LID)[1].

Name	ctap
Synonyms	L-Threoninamide, D-phenylalanyl-L-cysteinyl-L-tyrosyl-D-tryptophyl-L-ginyl-L-threonyl-3-mercapto-L-valyl-, cyclic (2→7)-disulfide CYS2,TYR3,ARG5,PEN7-AMIDE H-D-Phe-Cys-Tyr-D-Trp-g-Thr-Pen-Thr-NH (Disulfide bond between Cys and Pen) D-PHE-CYS-TYR-D-TRP-G-THR-PEN-THR-NH2(DISULFIDE BRIDGE:CYS2-PEN7) H-D-Phe-Cys-Tyr-D-Trp-g-Thr-Pen-Thr-NH2(Cys2-Pen7) CTAP,CTA cyclic D-Pen-Cys-Tyr-D-Trp-Arg-ThrPen-Thr-NH2 L-Threoninamide,D-phenylalanyl-L-cysteinyl-L-tyrosyl-D-tryptophyl-L-ginyl-L-threonyl-3-mercapto-L-valyl-,cyclic (2® CTAP-NH2 H-D-PHE-CYS-TYR-D-TRP-ARG-THR-PEN-THR-NH2 H-D-Phe-Cys-Tyr-D-Trp-g-Thr-Pen-Thr-NH2 (Disulfide bond between Cys2 and Pen7) (7S,10S,13R,16S,19R)-N-[(2S,3R)-1-Amino-3-hydroxy-1-oxo-2-butanyl]-10-(3-carbamimidamidopropyl)-16-(4-hydroxybenzyl)-7-[(1R)-1-hydroxyethyl]-13-(1H-indol-3-ylmethyl)-3,3-dimethyl-6,9,12,15,18-pentaoxo-19-(D-phenylalanylamino)-1,2-dithia-5,8,11,14,17-pentaazacycloicosane-4-carboxamide D-Phenylalanyl-L-cysteinyl-L-tyrosyl-D-tryptophyl-L-ginyl-L-threonyl-3-mercapto-L-valyl-L-threoninamide cyclic -disulfide 7)-disulfide CYS2, TYR3, G5, PEN7-AMIDE (4R,7S,10S,13R,16S,19R)-N-[(2S,3R)-1-Amino-3-hydroxy-1-oxo-2-butanyl]-10-(3-carbamimidamidopropyl)-16-(4-hydroxybenzyl)-7-[(1R)-1-hydroxyethyl]-13-(1H-indol-3-ylmethyl)-3,3-dimethyl-6,9,12,15,18-pentaoxo-19-(D-phenylalanylamino)-1,2-dithia-5,8,11,14,17-pentaazacycloicosane-4-carboxamide D-Phe-Cys-Tyr-D-Trp-Arg-Thr-Pen-Thr-NH2 D-Phe-L-Cys-L-Tyr-D-Trp-L-Arg-L-Thr-L-Pen-L-Thr-NH2 M.W. 1104.30 C51H69N13O11S2 CTAP, mu opioid antagonist C51H69N13O11S2 H-D-PHE-CYS-TYR-D-TRP-G-THR-PEN-THR-NH2 D-PHE-CYS-TYR-D-TRP-G-THR-PEN-THR-NH2 D-Phe-L-Cys-L-Tyr-D-Trp-L-g-L-Thr-L-Pen-L-Thr-NH2

Description	CTAP is a potent, highly selective, and brain penetrant μ opioid receptor antagonist (IC50=3.5 nM) and displays over 1200-fold selectivity over δ opioid (IC50=4500 nM) and somatostatin receptors. CTAP can be used for the study of L-DOPA-induced dyskinesia (LID)[1].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Opioid Receptor Signaling Pathways >> Neuronal Signaling >> Opioid Receptor Research Areas >> Neurological Disease
Target	IC50: 3.5 nM (μ opioid receptor) IC50: 4500 nM (δ opioid receptor)[1]
References	[1]. Mitchell J Bartlett, et al. Highly-selective µ-opioid Receptor Antagonism Does Not Block L-DOPA-induced Dyskinesia in a Rodent Model.BMC Res Notes

Density	1.5±0.1 g/cm3
Molecular Formula	C₅₁H₆₉N₁₃O₁₁S₂
Molecular Weight	1104.304
Exact Mass	1103.468140
PSA	461.79000
LogP	0.44
Index of Refraction	1.699
Storage condition	-20°C

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	Xi
RIDADR	NONH for all modes of transport
WGK Germany	3.0