173952-44-8

173952-44-8 structure

Name: SYM2206
Chemical Name: SYM 2206,(±)-4-(4-Aminophenyl)-1,2-dihydro-1-methyl-2-propylcarbamoyl-6,7-methylenedioxyphthalazine
CAS Number: 173952-44-8
Molecular Formula: C₂₀H₂₂N₄O₃
Molecular Weight: 366.41400
Catalog: Signaling Pathways Membrane Transporter/Ion Channel iGluR
Create Date: 2016-03-25 16:24:40
Modify Date: 2024-01-11 16:25:18
SYM 2206 is a novel, potent, non-competitive AMPA receptor antagonist (IC50= 2.8 μM).IC50 value: 2.8 μMTarget: AMPA receptorSYM 2206 exerts anticonvulsant effects, elevates the threshold for maximal electroshock-induced seizures in mice. TID20 and TID50(threshold increasing doses by 20% and 50%) values for SYM 2206 are 4.25 and 10.56 mg/kg in the MEST test in mice, respectively.

Name	SYM 2206,(±)-4-(4-Aminophenyl)-1,2-dihydro-1-methyl-2-propylcarbamoyl-6,7-methylenedioxyphthalazine
Synonyms	TRIS hydrochloride SYM 2206 SYM2206

Description	SYM 2206 is a novel, potent, non-competitive AMPA receptor antagonist (IC50= 2.8 μM).IC50 value: 2.8 μMTarget: AMPA receptorSYM 2206 exerts anticonvulsant effects, elevates the threshold for maximal electroshock-induced seizures in mice. TID20 and TID50(threshold increasing doses by 20% and 50%) values for SYM 2206 are 4.25 and 10.56 mg/kg in the MEST test in mice, respectively.
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> iGluR Signaling Pathways >> Neuronal Signaling >> iGluR Research Areas >> Neurological Disease
References	[1]. Jarogniew J. Luszczki,et al. SYM 2206 (a potent non-competitive AMPA receptor antagonist) elevates the threshold for maximal electroshock-induced seizures in mice. Curr. Issues Pharm. Med. Sci., Vol. 27, No. 2, Pages 80-83