SYM2206

Modify Date: 2024-01-11 16:25:18

SYM2206 Structure
SYM2206 structure
Common Name SYM2206
CAS Number 173952-44-8 Molecular Weight 366.41400
Density 1.37g/cm3 Boiling Point N/A
Molecular Formula C20H22N4O3 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of SYM2206


SYM 2206 is a novel, potent, non-competitive AMPA receptor antagonist (IC50= 2.8 μM).IC50 value: 2.8 μMTarget: AMPA receptorSYM 2206 exerts anticonvulsant effects, elevates the threshold for maximal electroshock-induced seizures in mice. TID20 and TID50(threshold increasing doses by 20% and 50%) values for SYM 2206 are 4.25 and 10.56 mg/kg in the MEST test in mice, respectively.

 Names

Name SYM 2206,(±)-4-(4-Aminophenyl)-1,2-dihydro-1-methyl-2-propylcarbamoyl-6,7-methylenedioxyphthalazine
Synonym More Synonyms

 SYM2206 Biological Activity

Description SYM 2206 is a novel, potent, non-competitive AMPA receptor antagonist (IC50= 2.8 μM).IC50 value: 2.8 μMTarget: AMPA receptorSYM 2206 exerts anticonvulsant effects, elevates the threshold for maximal electroshock-induced seizures in mice. TID20 and TID50(threshold increasing doses by 20% and 50%) values for SYM 2206 are 4.25 and 10.56 mg/kg in the MEST test in mice, respectively.
Related Catalog
References

[1]. Jarogniew J. Luszczki,et al. SYM 2206 (a potent non-competitive AMPA receptor antagonist) elevates the threshold for maximal electroshock-induced seizures in mice. Curr. Issues Pharm. Med. Sci., Vol. 27, No. 2, Pages 80-83

 Chemical & Physical Properties

Density 1.37g/cm3
Molecular Formula C20H22N4O3
Molecular Weight 366.41400
Exact Mass 366.16900
PSA 89.18000
LogP 3.59170
Index of Refraction 1.673
Storage condition 2-8℃

 Synonyms

TRIS hydrochloride
SYM 2206
SYM2206
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