70375-43-8
70375-43-8 structure
- Name: SCH-202676
- Chemical Name: (Z)-N-(2,3-diphenyl-1,2,4-thiadiazol-5(2H)-ylidene)methanamine
- CAS Number: 70375-43-8
- Molecular Formula: C15H14BrN3S
- Molecular Weight: 348.26100
- Catalog: Signaling Pathways Anti-infection Influenza Virus
- Create Date: 2016-07-02 12:26:18
- Modify Date: 2024-04-02 15:13:04
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SCH-202676 is an allosteric modulator of G protein-coupled receptors (GPCRs) and adenosine receptor (AR). SCH-202676 has antiviral activity and inhibits 3CLpro in a time-dependent manner with an IC50 value of 0.655 µM[1][2][3][4].
| Name | (Z)-N-(2,3-diphenyl-1,2,4-thiadiazol-5(2H)-ylidene)methanamine |
|---|---|
| Synonyms | aurora ka-7903 |
| Description | SCH-202676 is an allosteric modulator of G protein-coupled receptors (GPCRs) and adenosine receptor (AR). SCH-202676 has antiviral activity and inhibits 3CLpro in a time-dependent manner with an IC50 value of 0.655 µM[1][2][3][4]. |
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| Related Catalog | |
| Target |
Adenosine A3 receptor |
| In Vitro | SCH-202676 (compound 6a) 具有抗病毒活性并以时间依赖的方式抑制 3CLpro，在 0、5、10 和 20 分钟的 IC50 值分别为 0.409、0.302、0.206 和 0.191 µM[1]。 SCH-202676 (10 μM；90 min) 加强了大鼠前脑膜中 [35S]GTPγS 的标记[2]。 SCH-202676 抑制激动剂 [3H]UK-14,304 (HY-B0659) 和拮抗剂 [3H] 育亨宾 (Yohimbine，HY-12715) 与 α2a 肾上腺素能受体的结合[3]。 SCH-202676 (10 μM) 选择性地加速了激动剂在腺苷 A3 受体上的解离，减慢了拮抗剂在腺苷 Ai 受体上的解离，或加速了拮抗剂在腺苷 AzA 受体上的解离[4]。 |
| References |
| Boiling Point | 392ºC at 760 mmHg |
|---|---|
| Melting Point | 240.0-240.8ºC(lit.) |
| Molecular Formula | C15H14BrN3S |
| Molecular Weight | 348.26100 |
| Flash Point | 190.9ºC |
| Exact Mass | 347.00900 |
| PSA | 58.42000 |
| LogP | 4.08940 |
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70375-43-8 |
| Literature: Goerdeler,J. et al. Chemische Berichte, 1979 , vol. 112, p. 1288 - 1296 |
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70375-43-8 |
| Literature: Goerdeler,J. et al. Chemische Berichte, 1979 , vol. 112, p. 1288 - 1296 |
| Precursor 2 | |
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| DownStream 0 | |