SCH-202676

Modify Date: 2024-04-02 15:13:04

SCH-202676 structure	Common Name	SCH-202676
	CAS Number	70375-43-8	Molecular Weight	348.26100
	Density	N/A	Boiling Point	392ºC at 760 mmHg
	Molecular Formula	C₁₅H₁₄BrN₃S	Melting Point	240.0-240.8ºC(lit.)
	MSDS	N/A	Flash Point	190.9ºC

Use of SCH-202676

SCH-202676 is an allosteric modulator of G protein-coupled receptors (GPCRs) and adenosine receptor (AR). SCH-202676 has antiviral activity and inhibits 3CLpro in a time-dependent manner with an IC50 value of 0.655 µM[1][2][3][4].

Name	(Z)-N-(2,3-diphenyl-1,2,4-thiadiazol-5(2H)-ylidene)methanamine
Synonym	More Synonyms

Description	SCH-202676 is an allosteric modulator of G protein-coupled receptors (GPCRs) and adenosine receptor (AR). SCH-202676 has antiviral activity and inhibits 3CLpro in a time-dependent manner with an IC50 value of 0.655 µM[1][2][3][4].
Related Catalog	Signaling Pathways >> Anti-infection >> Influenza Virus Research Areas >> Infection Signaling Pathways >> GPCR/G Protein >> GPCR19 Signaling Pathways >> GPCR/G Protein >> Adenosine Receptor
Target	Adenosine A3 receptor
In Vitro	SCH-202676 (compound 6a) 具有抗病毒活性并以时间依赖的方式抑制 3CLpro，在 0、5、10 和 20 分钟的 IC50 值分别为 0.409、0.302、0.206 和 0.191 µM[1]。 SCH-202676 (10 μM；90 min) 加强了大鼠前脑膜中 [35S]GTPγS 的标记[2]。 SCH-202676 抑制激动剂 [3H]UK-14,304 (HY-B0659) 和拮抗剂 [3H] 育亨宾 (Yohimbine，HY-12715) 与 α2a 肾上腺素能受体的结合[3]。 SCH-202676 (10 μM) 选择性地加速了激动剂在腺苷 A3 受体上的解离，减慢了拮抗剂在腺苷 Ai 受体上的解离，或加速了拮抗剂在腺苷 AzA 受体上的解离[4]。
References	[1]. Ren P, et al. Discovery, synthesis and mechanism study of 2,3,5-substituted [1,2,4]-thiadiazoles as covalent inhibitors targeting 3C-Like protease of SARS-CoV-2. Eur J Med Chem. 2023 Jan 18;249:115129. [2]. Lewandowicz AM, et al. The 'allosteric modulator' SCH-202676 disrupts G protein-coupled receptor function via sulphydryl-sensitive mechanisms. Br J Pharmacol. 2006 Feb;147(4):422-9. [3]. Fawzi A B, et al. SCH-202676: an allosteric modulator of both agonist and antagonist binding to G protein-coupled receptors[J]. Molecular Pharmacology, 2001, 59(1): 30-37. [4]. Gao ZG, et al. Effects of the allosteric modulator SCH-202676 on adenosine and P2Y receptors. Life Sci. 2004 May 7;74(25):3173-80.

Boiling Point	392ºC at 760 mmHg
Melting Point	240.0-240.8ºC(lit.)
Molecular Formula	C₁₅H₁₄BrN₃S
Molecular Weight	348.26100
Flash Point	190.9ºC
Exact Mass	347.00900
PSA	58.42000
LogP	4.08940

Hazard Codes	Xi
Risk Phrases	36/37/38
Safety Phrases	26-36

1-methyl-3-[(ph...

CAS#:70375-39-2

SCH-202676

CAS#:70375-43-8

Literature: Goerdeler,J. et al. Chemische Berichte, 1979 , vol. 112, p. 1288 - 1296

1-chloro-N,1-di...

CAS#:4903-36-0

SCH-202676

CAS#:70375-43-8

Literature: Goerdeler,J. et al. Chemische Berichte, 1979 , vol. 112, p. 1288 - 1296

Precursor 2
CAS#:70375-39-2 1-methyl-3-[(ph... CAS#:4903-36-0 1-chloro-N,1-di...
DownStream 0

aurora ka-7903

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: SCH-202676
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Purity: 98.0%
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