Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Acifran
Price: Check
Purity: 98.0%
Stocking Period: 10 Day
Contact: Yang
Email: sales@echemcloud.com

DC Chemicals Limited
China
Product Name: Acifran
Price: $650.0/100mg $1100.0/250mg $2200.0/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

72420-38-3

72420-38-3 structure

72420-38-3 structure

Name: Acifran
Chemical Name: 5-methyl-4-oxo-5-phenylfuran-2-carboxylic acid
CAS Number: 72420-38-3
Molecular Formula: C₁₂H₁₀O₄
Molecular Weight: 218.20500
Catalog: Signaling Pathways GPCR/G Protein GPR109A
Create Date: 2018-02-11 08:00:00
Modify Date: 2025-08-25 08:29:02
Acifran (AY 25712), an antihyperlipidemic agent, is an orally active agonist of GPR109A (HM74A) and GPR109B, the high and low affinity receptors for Niacin[1][2].

Name	5-methyl-4-oxo-5-phenylfuran-2-carboxylic acid
Synonyms	Reductol ACIFRAN

Description	Acifran (AY 25712), an antihyperlipidemic agent, is an orally active agonist of GPR109A (HM74A) and GPR109B, the high and low affinity receptors for Niacin[1][2].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> GPCR/G Protein >> GPR109A
References	[1]. M N Cayen, et al. The metabolic disposition of acifran, a new antihyperlipidemic agent, in rats and dogs. Xenobiotica. 1986 Mar;16(3):251-63. [2]. Jae-Kyu Jung, et al. Analogues of acifran: agonists of the high and low affinity niacin receptors, GPR109a and GPR109b. J Med Chem. 2007 Apr 5;50(7):1445-8.

Density	1.343 g/cm3
Boiling Point	378.4ºC at 760 mmHg
Molecular Formula	C₁₂H₁₀O₄
Molecular Weight	218.20500
Flash Point	149.4ºC
Exact Mass	218.05800
PSA	63.60000
LogP	1.46960
Index of Refraction	1.591

CHEMICAL IDENTIFICATION

RTECS NUMBER :: LU0222000

CHEMICAL NAME :: 2-Furancarboxylic acid, 4,5-dihydro-5-methyl-4-oxo-5-phenyl-

CAS REGISTRY NUMBER :: 72420-38-3

LAST UPDATED :: 199009

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C12-H10-O4

MOLECULAR WEIGHT :: 218.22

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 25,1154,1982

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