Acifran

Modify Date: 2024-01-13 21:17:20

Acifran structure	Common Name	Acifran
	CAS Number	72420-38-3	Molecular Weight	218.20500
	Density	1.343 g/cm3	Boiling Point	378.4ºC at 760 mmHg
	Molecular Formula	C₁₂H₁₀O₄	Melting Point	N/A
	MSDS	N/A	Flash Point	149.4ºC

Use of Acifran

Acifran (AY 25712), an antihyperlipidemic agent, is an orally active agonist of GPR109A (HM74A) and GPR109B, the high and low affinity receptors for Niacin[1][2].

Name	5-methyl-4-oxo-5-phenylfuran-2-carboxylic acid
Synonym	More Synonyms

Description	Acifran (AY 25712), an antihyperlipidemic agent, is an orally active agonist of GPR109A (HM74A) and GPR109B, the high and low affinity receptors for Niacin[1][2].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> GPCR/G Protein >> GPR109A
References	[1]. M N Cayen, et al. The metabolic disposition of acifran, a new antihyperlipidemic agent, in rats and dogs. Xenobiotica. 1986 Mar;16(3):251-63. [2]. Jae-Kyu Jung, et al. Analogues of acifran: agonists of the high and low affinity niacin receptors, GPR109a and GPR109b. J Med Chem. 2007 Apr 5;50(7):1445-8.

Description

Acifran (AY 25712), an antihyperlipidemic agent, is an orally active agonist of GPR109A (HM74A) and GPR109B, the high and low affinity receptors for Niacin[1][2].

Related Catalog

Research Areas >> Cardiovascular Disease

Signaling Pathways >> GPCR/G Protein >> GPR109A

References

[1]. M N Cayen, et al. The metabolic disposition of acifran, a new antihyperlipidemic agent, in rats and dogs. Xenobiotica. 1986 Mar;16(3):251-63.

[2]. Jae-Kyu Jung, et al. Analogues of acifran: agonists of the high and low affinity niacin receptors, GPR109a and GPR109b. J Med Chem. 2007 Apr 5;50(7):1445-8.

Density	1.343 g/cm3
Boiling Point	378.4ºC at 760 mmHg
Molecular Formula	C₁₂H₁₀O₄
Molecular Weight	218.20500
Flash Point	149.4ºC
Exact Mass	218.05800
PSA	63.60000
LogP	1.46960
Index of Refraction	1.591

CHEMICAL IDENTIFICATION

RTECS NUMBER :: LU0222000

CHEMICAL NAME :: 2-Furancarboxylic acid, 4,5-dihydro-5-methyl-4-oxo-5-phenyl-

CAS REGISTRY NUMBER :: 72420-38-3

LAST UPDATED :: 199009

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C12-H10-O4

MOLECULAR WEIGHT :: 218.22

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 25,1154,1982

Reductol

ACIFRAN

DC Chemicals Limited
China
Product Name: Acifran
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

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Acifran

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