184241-44-9
184241-44-9 structure
- Name: NBI 27914 hydrochloride
- Chemical Name: 5-chloro-4-N-(cyclopropylmethyl)-2-methyl-4-N-propyl-6-N-(2,4,6-trichlorophenyl)pyrimidine-4,6-diamine
- CAS Number: 184241-44-9
- Molecular Formula: C18H21Cl5N4
- Molecular Weight: 470.65100
- Create Date: 2016-11-01 07:14:15
- Modify Date: 2025-08-21 14:31:12
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NBI-27914 is a potent and selective antagonist of CRFR1. The CRF receptors, CRFR1 and CRFR2, are members of the G protein-coupled receptor superfamily[1].
| Name | 5-chloro-4-N-(cyclopropylmethyl)-2-methyl-4-N-propyl-6-N-(2,4,6-trichlorophenyl)pyrimidine-4,6-diamine |
|---|---|
| Synonyms |
Lopac-N-3911
5-Chloro-4-(N-(cyclopropyl)methyl-N-propylamino)-2-methyl-6-(2,4,6-trichlorophenyl)aminopyridine Tocris-1591 NBI 27914 hydrochloride |
| Description | NBI-27914 is a potent and selective antagonist of CRFR1. The CRF receptors, CRFR1 and CRFR2, are members of the G protein-coupled receptor superfamily[1]. |
|---|---|
| Related Catalog | |
| References |
| Density | 1.417g/cm3 |
|---|---|
| Boiling Point | 483.7ºC at 760mmHg |
| Molecular Formula | C18H21Cl5N4 |
| Molecular Weight | 470.65100 |
| Flash Point | 246.3ºC |
| Exact Mass | 468.02100 |
| PSA | 41.05000 |
| LogP | 7.64360 |
| Appearance | solid white |
| Vapour Pressure | 1.64E-09mmHg at 25°C |
| Index of Refraction | 1.649 |
| Storage condition | 2-8°C |
| Water Solubility | DMSO: 16 mg/mL at 60 °C, soluble |
| Symbol |
GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H315-H319-H335 |
| Precautionary Statements | P261-P305 + P351 + P338 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
| Hazard Codes | Xi: Irritant; |
| Risk Phrases | R36/37/38 |
| Safety Phrases | S26 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |