Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 1,3-Naphthalenedisulfonicacid,6,6'-[(3,3'-dimethoxy[1,1'-biphenyl]-4,4'-diyl)bis(2,1-diazenediyl)]bis[4-amino-5-hydroxy-,sodium salt (1:4)
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

2610-05-1

2610-05-1 structure

Name: Direct Blue 1
Chemical Name: Chicago Sky Blue 6B,6,6'-[(3,3-Dimethoxy[1,1'-biphenyl]-4,4'-diyl)bis(azo)]bis[4-amino-5-hydroxy-1,3-napthalenedisulphonicacid]tetrasodiumsalt
CAS Number: 2610-05-1
Molecular Formula: C₃₄H₂₄N₆Na₄O₁₆S₄
Molecular Weight: 992.804
Catalog: Biochemical Biochemical reagent Biological dye
Create Date: 2018-04-24 08:00:00
Modify Date: 2026-07-16 21:28:36
Direct Blue 1 (Chicago Sky Blue 6B) is a counterstain for background autofluorescence in immunofluorescence histochemistry. Direct Blue 1, structurally related to glutamate, is a potent and competitive VGLUT inhibitor without affecting plasma membrane transporters. Direct Blue 1 is the first small molecule PrP ligand capable of inhibiting Aβ binding[1].

Name	Chicago Sky Blue 6B,6,6'-[(3,3-Dimethoxy[1,1'-biphenyl]-4,4'-diyl)bis(azo)]bis[4-amino-5-hydroxy-1,3-napthalenedisulphonicacid]tetrasodiumsalt
Synonyms	azinebrilliantblue6b directskyblue6bs chromeleatherskybluegs diazolpureblue6b CartaBlue2G chicago sky blue 6B azocdblue6b Chicago Sky Blue calcodurblue6gfl amanilskyblue6b directblue6bs EINECS 220-026-8 ChlorazolBlueFF directpureblueff CHICAGO BLUE MFCD00004020 atlanticskyblueff c.i.directblue1,tetrasodiumsalt benzanilskyblueff directbrightblue directpureskyblue C.1.DirectBlue2 directbrilliantbluemff Direct Blue 1 Pontamine sky blue benzanilsuprablue2gn diphenylbrilliantblueff nsb6b Pontamine Sky Blue 6B airedaleblueffd tetrasodium 6,6'-[(3,3'-dimethoxy[1,1'-biphenyl]-4,4'-diyl)bis(azo)]bis[4-amino-5-hydroxynaphthalene-1,3-disulphonate] calcodurresinfastblue belamineskyblueff skyblue6b 1,3-naphthalenedisulfonicacid,6,6’-[(3,3’-dimethoxy[1,1’-biphenyl]-4,4’-diyl) diazineskyblueff C. I. Direct blue I atlanticresinfastbluellgg directskybluegs CtaBlue paperblue6b directbrilliantblueff modrprima1 chlorantinefastblueb5gl cidirectblue1 Directturquoiseblue6B Tetrasodium 6,6'-[(3,3'-dimethoxy-4,4'-biphenyldiyl)di-2,1-diazenediyl]bis(4-amino-5-hydroxy-1,3-naphthalenedisulfonate) Chicago Sky Blue 6B directpureblue6b C.I.Directblue1 diaphtaminebluebs chloramineskyblueff Chicago Sky BlueB directskyblueff brilliantbenzoblue6ba-cf amanilskyblueff diacottonskyblue6b inkblue6b atuldirectskybluefb directblue6b directblueffn 1,3-Naphthalenedisulfonic acid, 6,6'-[(3,3'-dimethoxy[1,1'-biphenyl]-4,4'-diyl)di-2,1-diazenediyl]bis[4-amino-5-hydroxy-, sodium salt (1:4) directskyblueeenshade PontamineSkyBlueBX chromeleatherskyblue atlanticresinfastblue benzobrilliantblue6bs directblueff 6,8-naphthalenedisulfonicacid,3,3’-((3,3’-dimethoxy-4,4’-biphenylene)bis(azo) 1,3-Naphthalenedisulfonic acid, 6,6-(3,3-dimethoxy1,1-biphenyl-4,4-diyl)bis(azo)bis4-amino-5-hydroxy-, tetrasodium salt brasilaminaskyblue6b Direct Lake Blue 6B cresotineblue6b atlanticskyblue6b

Description	Direct Blue 1 (Chicago Sky Blue 6B) is a counterstain for background autofluorescence in immunofluorescence histochemistry. Direct Blue 1, structurally related to glutamate, is a potent and competitive VGLUT inhibitor without affecting plasma membrane transporters. Direct Blue 1 is the first small molecule PrP ligand capable of inhibiting Aβ binding[1].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease
References	[1]. Lodha N, Poojary SA. A Novel Contrast Stain for the Rapid Diagnosis of Pityriasis Versicolor: A Comparison of Chicago Sky Blue 6B Stain, Potassium Hydroxide Mount and Culture. Indian J Dermatol. 2015;60(4):340-344. [2]. Yu G, et al. The antinociceptive effects of intracerebroventricular administration of Chicago sky blue 6B, a vesicular glutamate transporter inhibitor. Behav Pharmacol. 2013;24(8):653-658. [3]. Risse E, et al. Identification of a Compound That Disrupts Binding of Amyloid-β to the Prion Protein Using a Novel Fluorescence-based Assay. J Biol Chem. 2015;290(27):17020-17028.

Molecular Formula	C₃₄H₂₄N₆Na₄O₁₆S₄
Molecular Weight	992.804
Exact Mass	991.972229
PSA	422.72000
LogP	10.18560
Storage condition	Store at RT

CHEMICAL IDENTIFICATION

RTECS NUMBER :: QJ6430000

CHEMICAL NAME :: 6,8-Naphthalenedisulfonic acid, 3,3'-((3,3'-dimethoxy-4,4'-biphenylene)bis(azo))bis( 5-amino-4-hydroxy-, tetrasodium salt

CAS REGISTRY NUMBER :: 2610-05-1

LAST UPDATED :: 199710

DATA ITEMS CITED :: 13

MOLECULAR FORMULA :: C34-H28-N6-O16-S4.4Na

MOLECULAR WEIGHT :: 996.88

WISWESSER LINE NOTATION :: L66J BZ CSWO ESWO JQ INUNR BO1 DR CO1 DNUN- IL66J BZ CSWO ESWO JQ &-NA- 4

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2260 mg/kg

TOXIC EFFECTS :: Cardiac - other changes Lungs, Thorax, or Respiration - other changes

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 200 mg/kg

SEX/DURATION :: female 8 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - Central Nervous System Reproductive - Specific Developmental Abnormalities - eye/ear Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 140 mg/kg

SEX/DURATION :: female 8 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 200 mg/kg

SEX/DURATION :: female 8 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - other effects to embryo

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 100 mg/kg

SEX/DURATION :: female 9 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - eye/ear

MUTATION DATA

TYPE OF TEST :: Mutation in microorganisms

TEST SYSTEM :: Bacteria - Salmonella typhimurium

DOSE/DURATION :: 100 nmol/plate

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 97,103,1982 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M2162 No. of Facilities: 53 (estimated) No. of Industries: 4 No. of Occupations: 6 No. of Employees: 1141 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M2162 No. of Facilities: 156 (estimated) No. of Industries: 7 No. of Occupations: 14 No. of Employees: 10195 (estimated) No. of Female Employees: 6491 (estimated)

Symbol	GHS08
Signal Word	Danger
Hazard Statements	H350
Precautionary Statements	P201-P308 + P313
Hazard Codes	Xn: Harmful;
Risk Phrases	R20/21/22
Safety Phrases	S24/25
RIDADR	UN 3143
WGK Germany	3
RTECS	QJ6430000

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