Direct Blue 1

Modify Date: 2024-01-12 10:47:05

Direct Blue 1 Structure
Direct Blue 1 structure
 Common Name Direct Blue 1
CAS Number 2610-05-1 Molecular Weight 992.804
Density N/A Boiling Point N/A
Molecular Formula C34H24N6Na4O16S4 Melting Point N/A
MSDS Chinese USA Flash Point N/A
Symbol GHS08
GHS08		 Signal Word Danger

 Use of Direct Blue 1


Direct Blue 1 (Chicago Sky Blue 6B) is a counterstain for background autofluorescence in immunofluorescence histochemistry. Direct Blue 1, structurally related to glutamate, is a potent and competitive VGLUT inhibitor without affecting plasma membrane transporters. Direct Blue 1 is the first small molecule PrP ligand capable of inhibiting Aβ binding[1].

 Names

Name Chicago Sky Blue 6B,6,6'-[(3,3-Dimethoxy[1,1'-biphenyl]-4,4'-diyl)bis(azo)]bis[4-amino-5-hydroxy-1,3-napthalenedisulphonicacid]tetrasodiumsalt
Synonym More Synonyms

 Direct Blue 1 Biological Activity

Description Direct Blue 1 (Chicago Sky Blue 6B) is a counterstain for background autofluorescence in immunofluorescence histochemistry. Direct Blue 1, structurally related to glutamate, is a potent and competitive VGLUT inhibitor without affecting plasma membrane transporters. Direct Blue 1 is the first small molecule PrP ligand capable of inhibiting Aβ binding[1].
Related Catalog
References

[1]. Lodha N, Poojary SA. A Novel Contrast Stain for the Rapid Diagnosis of Pityriasis Versicolor: A Comparison of Chicago Sky Blue 6B Stain, Potassium Hydroxide Mount and Culture. Indian J Dermatol. 2015;60(4):340-344.

[2]. Yu G, et al. The antinociceptive effects of intracerebroventricular administration of Chicago sky blue 6B, a vesicular glutamate transporter inhibitor. Behav Pharmacol. 2013;24(8):653-658.

[3]. Risse E, et al. Identification of a Compound That Disrupts Binding of Amyloid-β to the Prion Protein Using a Novel Fluorescence-based Assay. J Biol Chem. 2015;290(27):17020-17028.

 Chemical & Physical Properties

Molecular Formula C34H24N6Na4O16S4
Molecular Weight 992.804
Exact Mass 991.972229
PSA 422.72000
LogP 10.18560
Storage condition Store at RT

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
QJ6430000
CHEMICAL NAME :
6,8-Naphthalenedisulfonic acid, 3,3'-((3,3'-dimethoxy-4,4'-biphenylene)bis(azo))bis( 5-amino-4-hydroxy-, tetrasodium salt
CAS REGISTRY NUMBER :
2610-05-1
LAST UPDATED :
199710
DATA ITEMS CITED :
13
MOLECULAR FORMULA :
C34-H28-N6-O16-S4.4Na
MOLECULAR WEIGHT :
996.88
WISWESSER LINE NOTATION :
L66J BZ CSWO ESWO JQ INUNR BO1 DR CO1 DNUN- IL66J BZ CSWO ESWO JQ &-NA- 4

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
2260 mg/kg
TOXIC EFFECTS :
Cardiac - other changes Lungs, Thorax, or Respiration - other changes
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
DOSE :
200 mg/kg
SEX/DURATION :
female 8 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - Central Nervous System Reproductive - Specific Developmental Abnormalities - eye/ear Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
DOSE :
140 mg/kg
SEX/DURATION :
female 8 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
DOSE :
200 mg/kg
SEX/DURATION :
female 8 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - other effects to embryo
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
DOSE :
100 mg/kg
SEX/DURATION :
female 9 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - eye/ear

MUTATION DATA

TYPE OF TEST :
Mutation in microorganisms
TEST SYSTEM :
Bacteria - Salmonella typhimurium
DOSE/DURATION :
100 nmol/plate
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 97,103,1982 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M2162 No. of Facilities: 53 (estimated) No. of Industries: 4 No. of Occupations: 6 No. of Employees: 1141 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M2162 No. of Facilities: 156 (estimated) No. of Industries: 7 No. of Occupations: 14 No. of Employees: 10195 (estimated) No. of Female Employees: 6491 (estimated)

 Safety Information

Symbol GHS08
GHS08
Signal Word Danger
Hazard Statements H350
Precautionary Statements P201-P308 + P313
Hazard Codes Xn: Harmful;
Risk Phrases R20/21/22
Safety Phrases S24/25
RIDADR UN 3143
WGK Germany 3
RTECS QJ6430000

 Articles29

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Short-term in vivo evaluation of novel vital dyes for intraocular surgery.

Retina (Philadelphia, Pa.) 26(6) , 673-8, (2006)

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 Synonyms

paperblue6b
modrprima1
CartaBlue2G
Direct Blue 1
Direct Blue 1 Pontamine sky blue
1,3-Naphthalenedisulfonic acid, 6,6'-[(3,3'-dimethoxy[1,1'-biphenyl]-4,4'-diyl)di-2,1-diazenediyl]bis[4-amino-5-hydroxy-, sodium salt (1:4)
Chicago Sky Blue
nsb6b
Tetrasodium 6,6'-[(3,3'-dimethoxy-4,4'-biphenyldiyl)di-2,1-diazenediyl]bis(4-amino-5-hydroxy-1,3-naphthalenedisulfonate)
Chicago Sky Blue 6B
Pontamine Sky Blue 6B
EINECS 220-026-8
CHICAGO BLUE
MFCD00004020
skyblue6b
C. I. Direct blue I
inkblue6b
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Chemsrc provides Direct Blue 1(CAS#:2610-05-1) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of Direct Blue 1 are included as well.>> amp version: Direct Blue 1

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