Direct Blue 1

Modify Date: 2025-08-20 18:52:15

Direct Blue 1 structure	Common Name	Direct Blue 1
	CAS Number	2610-05-1	Molecular Weight	992.804
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₃₄H₂₄N₆Na₄O₁₆S₄	Melting Point	N/A
	MSDS	Chinese USA	Flash Point	N/A
	Symbol	GHS08	Signal Word	Danger

Use of Direct Blue 1

Direct Blue 1 (Chicago Sky Blue 6B) is a counterstain for background autofluorescence in immunofluorescence histochemistry. Direct Blue 1, structurally related to glutamate, is a potent and competitive VGLUT inhibitor without affecting plasma membrane transporters. Direct Blue 1 is the first small molecule PrP ligand capable of inhibiting Aβ binding[1].

Name	Chicago Sky Blue 6B,6,6'-[(3,3-Dimethoxy[1,1'-biphenyl]-4,4'-diyl)bis(azo)]bis[4-amino-5-hydroxy-1,3-napthalenedisulphonicacid]tetrasodiumsalt
Synonym	More Synonyms

Description	Direct Blue 1 (Chicago Sky Blue 6B) is a counterstain for background autofluorescence in immunofluorescence histochemistry. Direct Blue 1, structurally related to glutamate, is a potent and competitive VGLUT inhibitor without affecting plasma membrane transporters. Direct Blue 1 is the first small molecule PrP ligand capable of inhibiting Aβ binding[1].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease
References	[1]. Lodha N, Poojary SA. A Novel Contrast Stain for the Rapid Diagnosis of Pityriasis Versicolor: A Comparison of Chicago Sky Blue 6B Stain, Potassium Hydroxide Mount and Culture. Indian J Dermatol. 2015;60(4):340-344. [2]. Yu G, et al. The antinociceptive effects of intracerebroventricular administration of Chicago sky blue 6B, a vesicular glutamate transporter inhibitor. Behav Pharmacol. 2013;24(8):653-658. [3]. Risse E, et al. Identification of a Compound That Disrupts Binding of Amyloid-β to the Prion Protein Using a Novel Fluorescence-based Assay. J Biol Chem. 2015;290(27):17020-17028.

Description

Related Catalog

Signaling Pathways >> Others >> Others

Research Areas >> Neurological Disease

References

[1]. Lodha N, Poojary SA. A Novel Contrast Stain for the Rapid Diagnosis of Pityriasis Versicolor: A Comparison of Chicago Sky Blue 6B Stain, Potassium Hydroxide Mount and Culture. Indian J Dermatol. 2015;60(4):340-344.

[2]. Yu G, et al. The antinociceptive effects of intracerebroventricular administration of Chicago sky blue 6B, a vesicular glutamate transporter inhibitor. Behav Pharmacol. 2013;24(8):653-658.

[3]. Risse E, et al. Identification of a Compound That Disrupts Binding of Amyloid-β to the Prion Protein Using a Novel Fluorescence-based Assay. J Biol Chem. 2015;290(27):17020-17028.

Molecular Formula	C₃₄H₂₄N₆Na₄O₁₆S₄
Molecular Weight	992.804
Exact Mass	991.972229
PSA	422.72000
LogP	10.18560
InChIKey	BPHHNXJPFPEJOF-UHFFFAOYSA-J
SMILES	COc1cc(-c2ccc(N=Nc3ccc4c(S(=O)(=O)[O-])cc(S(=O)(=O)[O-])c(N)c4c3O)c(OC)c2)ccc1N=Nc1ccc2c(S(=O)(=O)[O-])cc(S(=O)(=O)[O-])c(N)c2c1O.[Na+].[Na+].[Na+].[Na+]
Storage condition	Store at RT

Direct Blue 1 MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: QJ6430000

CHEMICAL NAME :: 6,8-Naphthalenedisulfonic acid, 3,3'-((3,3'-dimethoxy-4,4'-biphenylene)bis(azo))bis( 5-amino-4-hydroxy-, tetrasodium salt

CAS REGISTRY NUMBER :: 2610-05-1

LAST UPDATED :: 199710

DATA ITEMS CITED :: 13

MOLECULAR FORMULA :: C34-H28-N6-O16-S4.4Na

MOLECULAR WEIGHT :: 996.88

WISWESSER LINE NOTATION :: L66J BZ CSWO ESWO JQ INUNR BO1 DR CO1 DNUN- IL66J BZ CSWO ESWO JQ &-NA- 4

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2260 mg/kg

TOXIC EFFECTS :: Cardiac - other changes Lungs, Thorax, or Respiration - other changes

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 200 mg/kg

SEX/DURATION :: female 8 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - Central Nervous System Reproductive - Specific Developmental Abnormalities - eye/ear Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 140 mg/kg

SEX/DURATION :: female 8 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 200 mg/kg

SEX/DURATION :: female 8 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - other effects to embryo

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 100 mg/kg

SEX/DURATION :: female 9 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - eye/ear

MUTATION DATA

TYPE OF TEST :: Mutation in microorganisms

TEST SYSTEM :: Bacteria - Salmonella typhimurium

DOSE/DURATION :: 100 nmol/plate

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 97,103,1982 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M2162 No. of Facilities: 53 (estimated) No. of Industries: 4 No. of Occupations: 6 No. of Employees: 1141 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M2162 No. of Facilities: 156 (estimated) No. of Industries: 7 No. of Occupations: 14 No. of Employees: 10195 (estimated) No. of Female Employees: 6491 (estimated)

Symbol	GHS08
Signal Word	Danger
Hazard Statements	H350
Precautionary Statements	P201-P308 + P313
Hazard Codes	Xn: Harmful;
Risk Phrases	R20/21/22
Safety Phrases	S24/25
RIDADR	UN 3143
WGK Germany	3
RTECS	QJ6430000

A comparison of the contrast stains, Chicago blue, chlorazole black, and Parker ink, for the rapid diagnosis of skin and nail infections.

Int. J. Dermatol. 51(8) , 935-8, (2012)

The cheapest, most rapid method for the diagnosis of mycotic skin and nail infections is direct examination of samples using a KOH preparation. The standard KOH wet mount lacks a color contrast. Vario...

Short-term in vivo evaluation of novel vital dyes for intraocular surgery.

Retina (Philadelphia, Pa.) 26(6) , 673-8, (2006)

To evaluate the staining characteristics and safety of potential new dyes for intraocular surgery in porcine eyes.Four dyes in different solutions (light green SF yellowish [LGSF]: 2%; copper(II) phth...

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To investigate the effect of intravitreal injections of new vital dyes on the retina, the retinal pigment epithelium (RPE) and the choroid in an in vivo rat model.Rats were injected intravitreally wit...

Name: Antiviral activity against HIV1 infected in human HeLa cells expressing CD4-LTR asses...
Source: ChEMBL
Target: Human immunodeficiency virus 1
External Id: CHEMBL1054765

Name: Chemical Probes of Kaposi's Sarcoma Herpes Virus Latent Infection
Source: ICCB-Longwood/NSRB Screening Facility, Harvard Medical School
Target: ORF 73 [Human herpesvirus 8 type M]
External Id: HMS791

Name: Inhibition of synthetic amyloid beta42 oligomer formation by Western blot
Source: ChEMBL
Target: N/A
External Id: CHEMBL936122

Name: Inhibition of synthetic amyloid beta-42 fibrillation by ThT fluorescence analysis rel...
Source: ChEMBL
Target: N/A
External Id: CHEMBL936124

Name: Inhibition of synthetic amyloid beta-42 fibrillation by light scattering analysis rel...
Source: ChEMBL
Target: N/A
External Id: CHEMBL936125

Name: Antiviral activity against HIV1 infected in human HeLa cells expressing CD4-LTR asses...
Source: ChEMBL
Target: Human immunodeficiency virus 1
External Id: CHEMBL1054771

Name: Inhibition of synthetic amyloid beta-42 oligomerization by ELISA
Source: ChEMBL
Target: N/A
External Id: CHEMBL936123

Name: Dicer-mediated maturation of pre-microRNA
Source: Center for Chemical Genomics, University of Michigan
Target: N/A
External Id: TargetID_659_CEMA

Name: qHTS for Inhibitors of binding or entry into cells for Marburg Virus
Source: NCGC
Target: gene 4 small orf - Marburg virus
External Id: VSVM-OFFLINE

Name: qHTS for Inhibitors of binding or entry into cells for Lassa Virus
Source: NCGC
Target: N/A
External Id: VSVL-OFFLINE

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paperblue6b

modrprima1

CartaBlue2G

Direct Blue 1

Direct Blue 1 Pontamine sky blue

1,3-Naphthalenedisulfonic acid, 6,6'-[(3,3'-dimethoxy[1,1'-biphenyl]-4,4'-diyl)di-2,1-diazenediyl]bis[4-amino-5-hydroxy-, sodium salt (1:4)

Chicago Sky Blue

nsb6b

Tetrasodium 6,6'-[(3,3'-dimethoxy-4,4'-biphenyldiyl)di-2,1-diazenediyl]bis(4-amino-5-hydroxy-1,3-naphthalenedisulfonate)

Chicago Sky Blue 6B

Pontamine Sky Blue 6B

EINECS 220-026-8

CHICAGO BLUE

MFCD00004020

skyblue6b

C. I. Direct blue I

inkblue6b

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Product Name: 1,3-Naphthalenedisulfonicacid,6,6'-[(3,3'-dimethoxy[1,1'-biphenyl]-4,4'-diyl)bis(2,1-diazenediyl)]bis[4-amino-5-hydroxy-,sodium salt (1:4)
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Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Direct Blue 1
Price: ￥118.0/5g ￥358.0/25g
Purity: 98.0%
Delivery: Inquiry
Contact: Liu jia
Email: 2130147988@qq.com

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HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

Safety Information

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Direct Blue 1Bioassay

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