149719-06-2

149719-06-2 structure

Name: RS 23597-190
Chemical Name: 3-piperidin-1-ylpropyl 4-amino-5-chloro-2-methoxybenzoate,hydrochloride
CAS Number: 149719-06-2
Molecular Formula: C₁₆H₂₄Cl₂N₂O₃
Molecular Weight: 363.27900
Catalog: Signaling Pathways GPCR/G Protein 5-HT Receptor
Create Date: 2018-06-20 00:57:10
Modify Date: 2024-01-10 12:42:13
RS 23597-190 (EP-A-501322) is a high affinity and selective 5-HT4 receptor antagonist. RS 23597-190 inhibits 5-HT-induced tachycardia. RS 23597-190 significantly inhibits superoxide production in high glucose[1][2].

Name	3-piperidin-1-ylpropyl 4-amino-5-chloro-2-methoxybenzoate,hydrochloride
Synonyms	Trequinsin hydrochloride

Description	RS 23597-190 (EP-A-501322) is a high affinity and selective 5-HT4 receptor antagonist. RS 23597-190 inhibits 5-HT-induced tachycardia. RS 23597-190 significantly inhibits superoxide production in high glucose[1][2].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor
Target	5-HT4 Receptor
In Vitro	RS 23597-190 (10 µM; 4 days) 在高葡萄糖 (30 mM)条件下显着抑制661W 细胞中超氧化物的产生[2]。
In Vivo	RS 23597-190 (6.0 mg/kg；静脉注射) 抑制微型猪中 5-HT 诱导的心动过速[1]. Animal Model: Bilaterally vagotomized micropig[1] Dosage: 6.0 mg/kg Administration: I.v. Result: Antagonized 5-HT-induced tachycardia with a half-life of 77 (63-99) min.
References	[1]. Eglen RM, et al. RS 23597-190: a potent and selective 5-HT4 receptor antagonist. Br J Pharmacol. 1993 Sep;110(1):119-26. [2]. Du Y, et al. Adrenergic and serotonin receptors affect retinal superoxide generation in diabetic mice: relationship to capillary degeneration and permeability. FASEB J. 2015 May;29(5):2194-204.

Hazard Codes	Xn
HS Code	2933399090

HS Code	2933399090
Summary	2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%