RS 23597-190

Modify Date: 2024-01-10 12:42:13

RS 23597-190 structure	Common Name	RS 23597-190
	CAS Number	149719-06-2	Molecular Weight	363.27900
	Density	N/A	Boiling Point	486.5ºC at 760 mmHg
	Molecular Formula	C₁₆H₂₄Cl₂N₂O₃	Melting Point	N/A
	MSDS	Chinese	Flash Point	248ºC

Use of RS 23597-190

RS 23597-190 (EP-A-501322) is a high affinity and selective 5-HT4 receptor antagonist. RS 23597-190 inhibits 5-HT-induced tachycardia. RS 23597-190 significantly inhibits superoxide production in high glucose[1][2].

Name	3-piperidin-1-ylpropyl 4-amino-5-chloro-2-methoxybenzoate,hydrochloride
Synonym	More Synonyms

Description	RS 23597-190 (EP-A-501322) is a high affinity and selective 5-HT4 receptor antagonist. RS 23597-190 inhibits 5-HT-induced tachycardia. RS 23597-190 significantly inhibits superoxide production in high glucose[1][2].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor
Target	5-HT4 Receptor
In Vitro	RS 23597-190 (10 µM; 4 days) 在高葡萄糖 (30 mM)条件下显着抑制661W 细胞中超氧化物的产生[2]。
In Vivo	RS 23597-190 (6.0 mg/kg；静脉注射) 抑制微型猪中 5-HT 诱导的心动过速[1]. Animal Model: Bilaterally vagotomized micropig[1] Dosage: 6.0 mg/kg Administration: I.v. Result: Antagonized 5-HT-induced tachycardia with a half-life of 77 (63-99) min.
References	[1]. Eglen RM, et al. RS 23597-190: a potent and selective 5-HT4 receptor antagonist. Br J Pharmacol. 1993 Sep;110(1):119-26. [2]. Du Y, et al. Adrenergic and serotonin receptors affect retinal superoxide generation in diabetic mice: relationship to capillary degeneration and permeability. FASEB J. 2015 May;29(5):2194-204.

Boiling Point	486.5ºC at 760 mmHg
Molecular Formula	C₁₆H₂₄Cl₂N₂O₃
Molecular Weight	363.27900
Flash Point	248ºC
Exact Mass	362.11600
PSA	64.79000
LogP	4.28470
Vapour Pressure	1.29E-09mmHg at 25°C

Hazard Codes	Xn
HS Code	2933399090

HS Code	2933399090
Summary	2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Trequinsin hydrochloride

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: RS 23597-190
Price: Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

DC Chemicals Limited
China
Product Name: Rs23597-190 Hydrochloride
Price: ￥Inquiry/100mg ￥Inquiry/250mg ￥Inquiry/1g
Purity: 98.0%
Delivery: 10 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 3-(PIPERIDIN-1-YL)PROPYL 4-AMINO-5-CHLORO-2-METHOXYBENZOATE HYDROCHLORIDE
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

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The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.