40254-90-8

40254-90-8 structure

Name: NSC693868
Chemical Name: Cdk 1/5 Inhibitor
CAS Number: 40254-90-8
Molecular Formula: C₉H₇N₅
Molecular Weight: 185.18500
Create Date: 2019-06-09 21:02:36
Modify Date: 2024-01-05 22:44:35
NSC693868 is a selective inhibitor of CDK1 and CDK5 with IC50s of 600 nM and 400 nM, respectively. NSC693868 less potently inhibits GSK3β with an IC50 of 1 µM) and does not block CDC25 activity. NSC693868 is used to help define the roles of CDK1 and CDK5 in various signaling pathways[1].

Name	Cdk 1/5 Inhibitor
Synonyms	MFCD04038461

Description	NSC693868 is a selective inhibitor of CDK1 and CDK5 with IC50s of 600 nM and 400 nM, respectively. NSC693868 less potently inhibits GSK3β with an IC50 of 1 µM) and does not block CDC25 activity. NSC693868 is used to help define the roles of CDK1 and CDK5 in various signaling pathways[1].
Related Catalog	Signaling Pathways >> Stem Cell/Wnt >> GSK-3 Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> CDK Signaling Pathways >> PI3K/Akt/mTOR >> GSK-3
Target	Cdk1/cyclin B:600 nM (IC50) Cdk5/p25:400 nM (IC50) GSK-3β:1 μM (IC50)
References	[1]. Ortega MA, et al. Pyrazolo[3,4-b]quinoxalines. A new class of cyclin-dependent kinases inhibitors. Bioorg Med Chem. 2002 Jul;10(7):2177-84.

Density	1.57g/cm3
Boiling Point	522.8ºC at 760mmHg
Molecular Formula	C₉H₇N₅
Molecular Weight	185.18500
Flash Point	303ºC
Exact Mass	185.07000
PSA	80.48000
LogP	1.66950
Index of Refraction	1.9

Hazard Codes	T+
HS Code	2933990090

40254-89-5

~87%

40254-90-8

Literature: Monge; Palop; Pinol; Martinez-Crespo; Narro; Gonzalez; Sainz; Lopez De Cerain; Hamilton; Barker Journal of Heterocyclic Chemistry, 1994 , vol. 31, # 5 p. 1135 - 1139