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40254-90-8

40254-90-8 structure
40254-90-8 structure
  • Name: NSC693868
  • Chemical Name: Cdk 1/5 Inhibitor
  • CAS Number: 40254-90-8
  • Molecular Formula: C9H7N5
  • Molecular Weight: 185.18500
  • Create Date: 2019-06-09 21:02:36
  • Modify Date: 2025-08-25 18:21:51
  • NSC693868 is a selective inhibitor of CDK1 and CDK5 with IC50s of 600 nM and 400 nM, respectively. NSC693868 less potently inhibits GSK3β with an IC50 of 1 µM) and does not block CDC25 activity. NSC693868 is used to help define the roles of CDK1 and CDK5 in various signaling pathways[1].
Name Cdk 1/5 Inhibitor
Synonyms MFCD04038461
Description NSC693868 is a selective inhibitor of CDK1 and CDK5 with IC50s of 600 nM and 400 nM, respectively. NSC693868 less potently inhibits GSK3β with an IC50 of 1 µM) and does not block CDC25 activity. NSC693868 is used to help define the roles of CDK1 and CDK5 in various signaling pathways[1].
Related Catalog
Target

Cdk1/cyclin B:600 nM (IC50)

Cdk5/p25:400 nM (IC50)

GSK-3β:1 μM (IC50)

References

[1]. Ortega MA, et al. Pyrazolo[3,4-b]quinoxalines. A new class of cyclin-dependent kinases inhibitors. Bioorg Med Chem. 2002 Jul;10(7):2177-84.
Density 1.57g/cm3
Boiling Point 522.8ºC at 760mmHg
Molecular Formula C9H7N5
Molecular Weight 185.18500
Flash Point 303ºC
Exact Mass 185.07000
PSA 80.48000
LogP 1.66950
Index of Refraction 1.9
Hazard Codes T+
HS Code 2933990090
40254-89-5 structure

40254-89-5

~87%

40254-90-8 structure

40254-90-8

Literature: Monge; Palop; Pinol; Martinez-Crespo; Narro; Gonzalez; Sainz; Lopez De Cerain; Hamilton; Barker Journal of Heterocyclic Chemistry, 1994 , vol. 31, # 5 p. 1135 - 1139
90323-01-6 structure

90323-01-6

~%

40254-90-8 structure

40254-90-8

Literature: Yoshida, Kei; Otomasu, Hirotaka Chemical and Pharmaceutical Bulletin, 1984 , vol. 32, # 9 p. 3361 - 3365
36818-07-2 structure

36818-07-2

~%

40254-90-8 structure

40254-90-8

Literature: Yoshida, Kei; Otomasu, Hirotaka Chemical and Pharmaceutical Bulletin, 1984 , vol. 32, # 9 p. 3361 - 3365
90415-26-2 structure

90415-26-2

~%

40254-90-8 structure

40254-90-8

Literature: Yoshida, Kei; Otomasu, Hirotaka Chemical and Pharmaceutical Bulletin, 1984 , vol. 32, # 9 p. 3361 - 3365
31055-87-5 structure

31055-87-5

~%

40254-90-8 structure

40254-90-8

Literature: Yoshida, Kei; Otomasu, Hirotaka Chemical and Pharmaceutical Bulletin, 1984 , vol. 32, # 9 p. 3361 - 3365
94951-42-5 structure

94951-42-5

~%

40254-90-8 structure

40254-90-8

Literature: Yoshida, Kei; Otomasu, Hirotaka Chemical and Pharmaceutical Bulletin, 1984 , vol. 32, # 9 p. 3361 - 3365
480-96-6 structure

480-96-6

~%

40254-90-8 structure

40254-90-8

Literature: Monge; Palop; Pinol; Martinez-Crespo; Narro; Gonzalez; Sainz; Lopez De Cerain; Hamilton; Barker Journal of Heterocyclic Chemistry, 1994 , vol. 31, # 5 p. 1135 - 1139
36597-16-7 structure

36597-16-7

~%

40254-90-8 structure

40254-90-8

Literature: Monge; Palop; Pinol; Martinez-Crespo; Narro; Gonzalez; Sainz; Lopez De Cerain; Hamilton; Barker Journal of Heterocyclic Chemistry, 1994 , vol. 31, # 5 p. 1135 - 1139
23190-84-3 structure

23190-84-3

~%

40254-90-8 structure

40254-90-8

Literature: Monge; Palop; Pinol; Martinez-Crespo; Narro; Gonzalez; Sainz; Lopez De Cerain; Hamilton; Barker Journal of Heterocyclic Chemistry, 1994 , vol. 31, # 5 p. 1135 - 1139
HS Code 2933990090
Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
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