40254-90-8
40254-90-8 structure
- Name: NSC693868
- Chemical Name: Cdk 1/5 Inhibitor
- CAS Number: 40254-90-8
- Molecular Formula: C9H7N5
- Molecular Weight: 185.18500
- Create Date: 2019-06-09 21:02:36
- Modify Date: 2024-01-05 22:44:35
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NSC693868 is a selective inhibitor of CDK1 and CDK5 with IC50s of 600 nM and 400 nM, respectively. NSC693868 less potently inhibits GSK3β with an IC50 of 1 µM) and does not block CDC25 activity. NSC693868 is used to help define the roles of CDK1 and CDK5 in various signaling pathways[1].
| Name | Cdk 1/5 Inhibitor |
|---|---|
| Synonyms | MFCD04038461 |
| Description | NSC693868 is a selective inhibitor of CDK1 and CDK5 with IC50s of 600 nM and 400 nM, respectively. NSC693868 less potently inhibits GSK3β with an IC50 of 1 µM) and does not block CDC25 activity. NSC693868 is used to help define the roles of CDK1 and CDK5 in various signaling pathways[1]. |
|---|---|
| Related Catalog | |
| Target |
Cdk1/cyclin B:600 nM (IC50) Cdk5/p25:400 nM (IC50) GSK-3β:1 μM (IC50) |
| References |
| Density | 1.57g/cm3 |
|---|---|
| Boiling Point | 522.8ºC at 760mmHg |
| Molecular Formula | C9H7N5 |
| Molecular Weight | 185.18500 |
| Flash Point | 303ºC |
| Exact Mass | 185.07000 |
| PSA | 80.48000 |
| LogP | 1.66950 |
| Index of Refraction | 1.9 |
| Hazard Codes | T+ |
|---|---|
| HS Code | 2933990090 |
|
~87%
40254-90-8 |
| Literature: Monge; Palop; Pinol; Martinez-Crespo; Narro; Gonzalez; Sainz; Lopez De Cerain; Hamilton; Barker Journal of Heterocyclic Chemistry, 1994 , vol. 31, # 5 p. 1135 - 1139 |
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40254-90-8 |
| Literature: Yoshida, Kei; Otomasu, Hirotaka Chemical and Pharmaceutical Bulletin, 1984 , vol. 32, # 9 p. 3361 - 3365 |
|
~%
40254-90-8 |
| Literature: Yoshida, Kei; Otomasu, Hirotaka Chemical and Pharmaceutical Bulletin, 1984 , vol. 32, # 9 p. 3361 - 3365 |
|
~%
40254-90-8 |
| Literature: Yoshida, Kei; Otomasu, Hirotaka Chemical and Pharmaceutical Bulletin, 1984 , vol. 32, # 9 p. 3361 - 3365 |
|
~%
40254-90-8 |
| Literature: Yoshida, Kei; Otomasu, Hirotaka Chemical and Pharmaceutical Bulletin, 1984 , vol. 32, # 9 p. 3361 - 3365 |
|
~%
40254-90-8 |
| Literature: Yoshida, Kei; Otomasu, Hirotaka Chemical and Pharmaceutical Bulletin, 1984 , vol. 32, # 9 p. 3361 - 3365 |
|
~%
40254-90-8 |
| Literature: Monge; Palop; Pinol; Martinez-Crespo; Narro; Gonzalez; Sainz; Lopez De Cerain; Hamilton; Barker Journal of Heterocyclic Chemistry, 1994 , vol. 31, # 5 p. 1135 - 1139 |
|
~%
40254-90-8 |
| Literature: Monge; Palop; Pinol; Martinez-Crespo; Narro; Gonzalez; Sainz; Lopez De Cerain; Hamilton; Barker Journal of Heterocyclic Chemistry, 1994 , vol. 31, # 5 p. 1135 - 1139 |
|
~%
40254-90-8 |
| Literature: Monge; Palop; Pinol; Martinez-Crespo; Narro; Gonzalez; Sainz; Lopez De Cerain; Hamilton; Barker Journal of Heterocyclic Chemistry, 1994 , vol. 31, # 5 p. 1135 - 1139 |
| Precursor 5 | |
|---|---|
| DownStream 1 | |
![3-Chloro-1H-pyrazolo[3,4-b]quinoxaline structure](https://www.chemsrc.com/caspic/136/160315-07-1.png)
| HS Code | 2933990090 |
|---|---|
| Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |