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136310-93-5

136310-93-5 structure
136310-93-5 structure
  • Name: Tiotropium bromide
  • Chemical Name: Tiotropium Bromide
  • CAS Number: 136310-93-5
  • Molecular Formula: C19H22BrNO4S2
  • Molecular Weight: 472.416
  • Catalog: API Respiratory medication Asthma
  • Create Date: 2018-04-16 08:00:00
  • Modify Date: 2024-01-01 20:11:12
  • Tiotropium Bromide (BA679 BR) is a muscarinic acetylcholine receptor (mAChR) antagonist that blocks the binding of the acetylcholine ligand and subsequent opening of the ligand-gated ion channel.
Name Tiotropium Bromide
Synonyms Tiova
3-Oxa-9-azoniatricyclo[3.3.1.0]nonane, 7-[(2-hydroxy-2,2-di-2-thienylacetyl)oxy]-9,9-dimethyl-, bromide, (1R,2R,4S,5S)- (1:1)
MFCD00867027
(1a,2b,4b,5a,7b)-7-[(Hydroxydi-2-thienylacetyl)oxy]-9,9-dimethyl-3-oxa-9-azoniatricyclo[3.3.1.0 2,4 ]nonane bromide
BA 679 BR
(1R,2R,4S,5S,7S)-7-{[hydroxy(dithiophen-2-yl)acetyl]oxy}-9,9-dimethyl-3-oxa-9-azoniatricyclo[3.3.1.0]nonane bromide
6b,7b-Epoxy-3b-hydroxy-8-methyl-1aH,5aH-tropanium bromide di-2-thienylglycolate
Spiriva Handihaler
TIOTROPIUM BROMIDE
(1R,2R,4S,5S,7s)-7-[2-Hydroxy(di-2-thienyl)acetoxy]-9,9-dimethyl-3-oxa-9-azoniatricyclo[3.3.1.0]nonane bromide
Spiriva
Tiotropium (Bromide)
Description Tiotropium Bromide (BA679 BR) is a muscarinic acetylcholine receptor (mAChR) antagonist that blocks the binding of the acetylcholine ligand and subsequent opening of the ligand-gated ion channel.
Related Catalog
Target

mAChR
In Vitro Tiotropium Bromide stops signaling between neurons and leads to muscle relaxation. Tiotropium Bromide is a long-acting, 24 hour, anticholinergic bronchodilator used in the management of chronic obstructive pulmonary disease. Tiotropium Bromide improves symptoms of chronic obstructive pulmonary disease complicated by chronic heart failure.
References

[1]. Barnes PJ. Tiotropium bromide. Expert Opin Investig Drugs. 2001 Apr;10(4):733-40.

[2]. ZuWallack AR, ZuWallack RL. Tiotropium bromide, a new, once-daily inhaled anticholinergic bronchodilator for chronic-obstructive pulmonary disease. Expert Opin Pharmacother. 2004 Aug;5(8):1827-35.

[3]. Lipson DA. Tiotropium bromide. Int J Chron Obstruct Pulmon Dis. 2006;1(2):107-14.

[4]. Mamary AJ, Criner GJ. Tiotropium bromide for chronic obstructive pulmonary disease. Expert Rev Respir Med. 2009 Jun;3(3):211-20.

[5]. Szmidt M. [The influence of treatment with formoterol, formoterol with tiotropium, formoterol with inhaled glucocorticosteroid and tiotropium on lung functions, tolerance of exercise and simple, morning everyday activities in patients with chronic obstructive pulmonary disease (COPD)]. Pneumonol Alergol Pol. 2012;80(3):255-62.
Melting Point 218-2200C
Molecular Formula C19H22BrNO4S2
Molecular Weight 472.416
Exact Mass 471.017365
PSA 115.54000
Storage condition Refrigerator
Hazard Codes Xi
Risk Phrases R36:Irritating to the eyes.
Safety Phrases S23-S24/25
WGK Germany 3
HS Code 29309070
HS Code 29309070

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title: CAS No. 136310-93-5 | Chemsrc address: https://m.chemsrc.com/en/baike/587967.html

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