Tiotropium bromide

Modify Date: 2024-01-01 20:11:12

Tiotropium bromide Structure
Tiotropium bromide structure
 Common Name Tiotropium bromide
CAS Number 136310-93-5 Molecular Weight 472.416
Density N/A Boiling Point N/A
Molecular Formula C19H22BrNO4S2 Melting Point 218-2200C
MSDS N/A Flash Point N/A

 Use of Tiotropium bromide


Tiotropium Bromide (BA679 BR) is a muscarinic acetylcholine receptor (mAChR) antagonist that blocks the binding of the acetylcholine ligand and subsequent opening of the ligand-gated ion channel.

 Names

Name Tiotropium Bromide
Synonym More Synonyms

 Tiotropium bromide Biological Activity

Description Tiotropium Bromide (BA679 BR) is a muscarinic acetylcholine receptor (mAChR) antagonist that blocks the binding of the acetylcholine ligand and subsequent opening of the ligand-gated ion channel.
Related Catalog
Target

mAChR
In Vitro Tiotropium Bromide stops signaling between neurons and leads to muscle relaxation. Tiotropium Bromide is a long-acting, 24 hour, anticholinergic bronchodilator used in the management of chronic obstructive pulmonary disease. Tiotropium Bromide improves symptoms of chronic obstructive pulmonary disease complicated by chronic heart failure.
References

[1]. Barnes PJ. Tiotropium bromide. Expert Opin Investig Drugs. 2001 Apr;10(4):733-40.

[2]. ZuWallack AR, ZuWallack RL. Tiotropium bromide, a new, once-daily inhaled anticholinergic bronchodilator for chronic-obstructive pulmonary disease. Expert Opin Pharmacother. 2004 Aug;5(8):1827-35.

[3]. Lipson DA. Tiotropium bromide. Int J Chron Obstruct Pulmon Dis. 2006;1(2):107-14.

[4]. Mamary AJ, Criner GJ. Tiotropium bromide for chronic obstructive pulmonary disease. Expert Rev Respir Med. 2009 Jun;3(3):211-20.

[5]. Szmidt M. [The influence of treatment with formoterol, formoterol with tiotropium, formoterol with inhaled glucocorticosteroid and tiotropium on lung functions, tolerance of exercise and simple, morning everyday activities in patients with chronic obstructive pulmonary disease (COPD)]. Pneumonol Alergol Pol. 2012;80(3):255-62.

 Chemical & Physical Properties

Melting Point 218-2200C
Molecular Formula C19H22BrNO4S2
Molecular Weight 472.416
Exact Mass 471.017365
PSA 115.54000
Storage condition Refrigerator

 Safety Information

Hazard Codes Xi
Risk Phrases R36:Irritating to the eyes.
Safety Phrases S23-S24/25
WGK Germany 3
HS Code 29309070

 Customs

HS Code 29309070

 Synonyms

Tiova
3-Oxa-9-azoniatricyclo[3.3.1.0]nonane, 7-[(2-hydroxy-2,2-di-2-thienylacetyl)oxy]-9,9-dimethyl-, bromide, (1R,2R,4S,5S)- (1:1)
MFCD00867027
(1a,2b,4b,5a,7b)-7-[(Hydroxydi-2-thienylacetyl)oxy]-9,9-dimethyl-3-oxa-9-azoniatricyclo[3.3.1.0 2,4 ]nonane bromide
BA 679 BR
(1R,2R,4S,5S,7S)-7-{[hydroxy(dithiophen-2-yl)acetyl]oxy}-9,9-dimethyl-3-oxa-9-azoniatricyclo[3.3.1.0]nonane bromide
6b,7b-Epoxy-3b-hydroxy-8-methyl-1aH,5aH-tropanium bromide di-2-thienylglycolate
Spiriva Handihaler
TIOTROPIUM BROMIDE
(1R,2R,4S,5S,7s)-7-[2-Hydroxy(di-2-thienyl)acetoxy]-9,9-dimethyl-3-oxa-9-azoniatricyclo[3.3.1.0]nonane bromide
Spiriva
Tiotropium (Bromide)
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Related Compounds: More...
Tiotropium Bromide
139404-48-1
Tiotropium bromide hydrate
411207-31-3
Tiotropium Bromide Impurity 3
136310-95-7
Tiotropium Bromide Impurity 6
704-38-1
Tiotropium Bromide Impurity 5
26447-85-8
Tiotropium Bromide Impurity 4
136310-66-2
TiotropiuM BroMide IMpurity D
736108-96-6
Tiotropium Bromide Impurity I
136521-48-7
Tiotropium Bromide Impurity G
1508-46-9
Chemsrc provides Tiotropium bromide(CAS#:136310-93-5) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of Tiotropium bromide are included as well.>> amp version: Tiotropium bromide

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