1553-56-6

1553-56-6 structure

Name: 3-Oxo-5β-cholanoic acid
Chemical Name: 3-oxo-5β-cholanic acid
CAS Number: 1553-56-6
Molecular Formula: C₂₄H₃₈O₃
Molecular Weight: 374.55700
Catalog: Signaling Pathways Metabolic Enzyme/Protease ROR
Create Date: 2016-07-23 19:14:49
Modify Date: 2026-07-16 21:23:21
3-Oxo-5β-cholanoic acid (Dehydrolithocholic acid), a bile acid metabolite, inhibits the diferentiation of TH17 cells by directly binding to the key transcription factor RORγt (Kd=1.13 μM)[1].

Name	3-oxo-5β-cholanic acid
Synonyms	3-ketolithocholicacid 3-oxocholanic acid 3-oxocholan-24-oic acid 3-oxo-5-beta-cholan-24-oicacid 5β-Cholanic acid-3-one 3-Oxo-5β-cholanoic Acid (R)-4-((5R,8R,9S,10S,13R,14S,17R)-10,13-Dimethyl-3-oxohexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoic acid 3-Keto-5beta-cholanic acid (5-beta)-cholan-24-oicaci 3-Oxo-5β-cholan-24-oic acid 3-Keto-5β-cholanic acid 3-oxocholanicacid 3-oxo-5-beta-cholan-24-oicaci Ursodeoxycholic acid impurity 60 DEHYDROLITHOCHOLIC ACID 3-Oxo-5β-cholanoic acid, 10 mM in DMSO 5-B-CHOLANIC ACID-3-ONE 3-Oxo-5β-cholanic acid Cholan-24-oic acid, 3-oxo-, (5β) 3-Keto-5β-cholanic acid, Dehydrolithocholic acid 3-KETOCHOLANIC ACID 5BETA-CHOLANIC ACID-3-ONE 3-Oxo-5beta-cholanoic Acid cell,factor,R-related orphan rector,3 Oxo 5β cholanoic acid,TH17,RORγt,differentiation,acid,bile,Inhibitor,responses,transcription,inhibit,ROR,3Oxo5βcholanoic acid,immune,3-oxoLCA 3-oxolithocholicacid 3-oxo-5beta-cholanic acid

Description	3-Oxo-5β-cholanoic acid (Dehydrolithocholic acid), a bile acid metabolite, inhibits the diferentiation of TH17 cells by directly binding to the key transcription factor RORγt (Kd=1.13 μM)[1].
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> ROR Research Areas >> Inflammation/Immunology
In Vitro	Treatment with 3-Oxo-5β-cholanoic acid significantly reduced the activity of the RORγt reporter. These data suggest that 3-Oxo-5β-cholanoic acid probably inhibits TH17 cell differentiation by physically interacting with RORγt, and inhibiting its transcriptional activity[1].
In Vivo	3-Oxo-5β-cholanoic acid (Dehydrolithocholic acid) (0.3% (w/w); p.o.; for 1 week) significantly reduces the percentage of ileal TH17 cells[1]. Animal Model: B6 Jax mice (with a faecal slurry containing SFB)[1] Dosage: 0.3% (w/w) Administration: Gavaged; for 1 week Result: Significantly reduced the percentage of ileal TH17 cells.
References	[1]. Hang S, et al. Bile acid metabolites control TH17 and Treg cell differentiation. Nature. 2019 Dec;576(7785):143-148.

REFERENCE :: CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980- Volume(issue)/page/year: 4,1179,1983

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Literature: Nahar, Lutfun; Turner, Alan B. Journal of Chemical Research, 2004 , # 5 p. 329 - 332

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Literature: Faarup, Peter Patent: US2002/183531 A1, 2002 ;

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