Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Estra-1,3,5(10)-trien-17-one,3-(sulfooxy)-, sodium salt (1:1)
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438-67-5

438-67-5 structure

Name: Estrone sulfate sodium
Chemical Name: estrone sodium sulfate
CAS Number: 438-67-5
Molecular Formula: C₁₈H₂₁NaO₅S
Molecular Weight: 372.41
Catalog: Research Areas Cancer
Create Date: 2018-07-25 10:27:38
Modify Date: 2026-07-05 19:04:13
Estrone sulfate, a biologically inactive form of estrogen, is a major circulating plasma estrogen that is converted into the biologically active estrogen, estrone (E1) by steroid sulfatase (STS). strone sulfate can be used for the research of breast cancer[1][2].

Name	estrone sodium sulfate
Synonyms	1,3,5-ESTRATRIEN-3-OL-17-ONE 3-SULFATE SODIUM SODIUMOESTRONESULPHATE 3-HYDROXY-1,3,5-ESTRATRIEN-17-ONE 3-SULFATE SODIUM SALT estrone,hydrogensulfate,sodiumsalt Estra-1,3,5-trien-17-one 3-(Sulfooxy) Sodium Salt Estrone Impurity 7 ESTRONE SODIUM SULPHATE estrone sodium sulphate Estrone 3-sulfate sodium salt,1,3,5-Estratrien-17-one 3-sulfate 17β-Estrone 3-sulfate ESTROGENIC SUBSTANCES Estrone-3-sulfate sodium salt Estrone 3-Sulfate Sodium Salt, with TRIS DISCONTINUED. See E889070 morestin estrone 3-sulfate sodium Estrone-3-sulfate Estrogenic substances (conjugated) Sodium estrone 3-sulfate Estrone-3-sulphate sodiumQ: What is Estrone-3-sulphate sodium Q: What is the CAS Number of Estrone-3-sulphate sodium Q: What is the storage condition of Estrone-3-sulphate sodium Q: What e the applications of Estrone-3-sulphate sodium sodiumestrone-3-sulfate Estra-1(10),2,4-trien-17-one, 3-(sulfooxy)-, sodium salt (1:1) Estrone 3-Sulfate Sodium Salt, with TRIS sodiumestronesulfate 1,3,5-ESTRATRIEN-3-OL-17-ONE SULPHATE, SODIUM SALT Estron sodium sulfate ESTRONE 3-SULFATE SODIUM SALT Estrone 3-sulfate (sodium salt)\|\|\|17β-Estrone 3-sulfate 1,3,5-ESTRATRIEN-3-OL-17-ONE SULFATE SODIUM SALT conestoral 3-(Sodiosulfooxy)-1,3,5-estratrien-17-one Sodium 17-oxoestra-1(10),2,4-trien-3-yl sulfate Estrone 3-sulfate sodium salt Estrone sodium sulfate 1,3,5-ESTRATRIEN-17-ONE 3-SULFATE SODIUM SALT estronesulfatesodiumsalt Estrone 3-O-sulfate, sodium salt oestrone-3-sulphatesodiumsalt Hyhorin Sulfuric acid sodium 17-oxo-1,3,5-estratriene-3-yl ester salt 3,5-trien-17-one,3-(sulfooxy)-estra-sodiumsalt ESTRONE SULFATE SODIUM SODIUMESTRONESULPHATE 3-HYDROXY-1,3,5-ESTRATRIEN-17-ONE 3-SULPHATE estronesodiumsulfate

Description	Estrone sulfate, a biologically inactive form of estrogen, is a major circulating plasma estrogen that is converted into the biologically active estrogen, estrone (E1) by steroid sulfatase (STS). strone sulfate can be used for the research of breast cancer[1][2].
Related Catalog	Signaling Pathways >> Others >> Estrogen Receptor/ERR Research Areas >> Cancer
Target	Human Endogenous Metabolite
In Vitro	T47D cells are stably transfected with SOAT and incubated under increasing concentrations of Estrone sulfate and estradiol at physiologically relevant concentrations. Cell proliferation is significantly increased by 1 nM estradiol as well as by Estrone sulfate with EC50 of 2.2 nM[3].
References	[1]. Nakamura Y, et al. Steroid sulfatase and estrogen sulfotransferase in the atherosclerotic human aorta. Am J Pathol. 2003;163(4):1329-1339. [2]. Duncan L, et al. Inhibition of estrone sulfatase activity by estrone-3-methylthiophosphonate: a potential therapeutic agent in breast cancer. Cancer Res. 1993;53(2):298-303. [3]. Karakus E, et al. Estrone-3-Sulfate Stimulates the Proliferation of T47D Breast Cancer Cells Stably Transfected With the Sodium-Dependent Organic Anion Transporter SOAT (SLC10A6). Front Pharmacol. 2018;9:941. Published 2018 Aug 21.

Density	1.349 g/cm3
Melting Point	258-260°C
Molecular Formula	C₁₈H₂₁NaO₅S
Molecular Weight	372.41
Exact Mass	372.100739
PSA	91.88000
LogP	4.03160
Storage condition	-20°C

CHEMICAL IDENTIFICATION

RTECS NUMBER :: KG8775000

CHEMICAL NAME :: Estrone, hydrogen sulfate, sodium salt

CAS REGISTRY NUMBER :: 438-67-5

LAST UPDATED :: 199509

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C18-H22-O5-S.Na

MOLECULAR WEIGHT :: 373.45

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 504 ug/kg

SEX/DURATION :: female 9 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Maternal Effects - menstrual cycle changes or disorders

REFERENCE :: JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1960- Volume(issue)/page/year: 55,191,1979

Symbol	GHS07, GHS08
Signal Word	Danger
Hazard Statements	H315-H319-H335-H350
Precautionary Statements	P201-P261-P305 + P351 + P338-P308 + P313
Hazard Codes	T: Toxic;
Risk Phrases	R45-36/37/38
Safety Phrases	S53-45-26
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	KG8775000

Precursor 2
878408-57-2 53-16-7
DownStream 1
53-16-7

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