Estrone sulfate sodium

Modify Date: 2026-07-05 19:04:13

Estrone sulfate sodium structure	Common Name	Estrone sulfate sodium
	CAS Number	438-67-5	Molecular Weight	372.41
	Density	1.349 g/cm3	Boiling Point	N/A
	Molecular Formula	C₁₈H₂₁NaO₅S	Melting Point	258-260°C
	MSDS	Chinese USA	Flash Point	N/A
	Symbol	GHS07, GHS08	Signal Word	Danger

Use of Estrone sulfate sodium

Estrone sulfate, a biologically inactive form of estrogen, is a major circulating plasma estrogen that is converted into the biologically active estrogen, estrone (E1) by steroid sulfatase (STS). strone sulfate can be used for the research of breast cancer[1][2].

This table lists Chinese names, IUPAC names and various aliases of this chemical substance.

Name	estrone sodium sulfate
Synonym	More Synonyms

This table contains bioactivity, target information and biological‑assay experimental data of this compound.

Description	Estrone sulfate, a biologically inactive form of estrogen, is a major circulating plasma estrogen that is converted into the biologically active estrogen, estrone (E1) by steroid sulfatase (STS). strone sulfate can be used for the research of breast cancer[1][2].
Related Catalog	Signaling Pathways >> Others >> Estrogen Receptor/ERR Research Areas >> Cancer
Target	Human Endogenous Metabolite
In Vitro	T47D cells are stably transfected with SOAT and incubated under increasing concentrations of Estrone sulfate and estradiol at physiologically relevant concentrations. Cell proliferation is significantly increased by 1 nM estradiol as well as by Estrone sulfate with EC50 of 2.2 nM[3].
References	[1]. Nakamura Y, et al. Steroid sulfatase and estrogen sulfotransferase in the atherosclerotic human aorta. Am J Pathol. 2003;163(4):1329-1339. [2]. Duncan L, et al. Inhibition of estrone sulfatase activity by estrone-3-methylthiophosphonate: a potential therapeutic agent in breast cancer. Cancer Res. 1993;53(2):298-303. [3]. Karakus E, et al. Estrone-3-Sulfate Stimulates the Proliferation of T47D Breast Cancer Cells Stably Transfected With the Sodium-Dependent Organic Anion Transporter SOAT (SLC10A6). Front Pharmacol. 2018;9:941. Published 2018 Aug 21.

This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.

Density	1.349 g/cm3
Melting Point	258-260°C
Molecular Formula	C₁₈H₂₁NaO₅S
Molecular Weight	372.41
Exact Mass	372.100739
PSA	91.88000
LogP	4.03160
InChIKey	VUCAHVBMSFIGAI-ZFINNJDLSA-M
SMILES	CC12CCC3c4ccc(OS(=O)(=O)[O-])cc4CCC3C1CCC2=O.[Na+]
Storage condition	-20°C

This table summarizes toxicological test data, acute & chronic toxicity and ecological hazard parameters for this chemical.

CHEMICAL IDENTIFICATION

RTECS NUMBER :: KG8775000

CHEMICAL NAME :: Estrone, hydrogen sulfate, sodium salt

CAS REGISTRY NUMBER :: 438-67-5

LAST UPDATED :: 199509

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C18-H22-O5-S.Na

MOLECULAR WEIGHT :: 373.45

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 504 ug/kg

SEX/DURATION :: female 9 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Maternal Effects - menstrual cycle changes or disorders

REFERENCE :: JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1960- Volume(issue)/page/year: 55,191,1979

This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.

Symbol	GHS07, GHS08
Signal Word	Danger
Hazard Statements	H315-H319-H335-H350
Precautionary Statements	P201-P261-P305 + P351 + P338-P308 + P313
Hazard Codes	T: Toxic;
Risk Phrases	R45-36/37/38
Safety Phrases	S53-45-26
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	KG8775000

This table lists upstream starting materials and downstream derivative products related to this chemical.

Precursor 2
CAS#:878408-57-2 estrone neopent... CAS#:53-16-7 Estrone
DownStream 1
CAS#:53-16-7 Estrone

This table lists relevant public references with title, journal and publication metadata for this compound.

Major active components in grapefruit, orange, and apple juices responsible for OATP2B1-mediated drug interactions.

J. Pharm. Sci. 102(1) , 280-8, (2013)

We aimed to explore the major active components in grapefruit juice (GFJ), orange juice (OJ), and apple juice (AJ) that are responsible for OATP2B1-mediated drug interactions, by means of in vitro stu...

Quantitative transporter proteomics by liquid chromatography with tandem mass spectrometry: addressing methodologic issues of plasma membrane isolation and expression-activity relationship.

Drug Metab. Dispos. 43(2) , 284-8, (2015)

To predict transporter-mediated drug disposition using physiologically based pharmacokinetic models, one approach is to measure transport activity and relate it to protein expression levels in cell li...

Inclusion of endogenous hormone levels in risk prediction models of postmenopausal breast cancer.

J. Clin. Oncol. 32(28) , 3111-7, (2014)

Endogenous hormones are risk factors for postmenopausal breast cancer, and their measurement may improve our ability to identify high-risk women. Therefore, we evaluated whether inclusion of plasma es...

This table contains target information, in‑vitro & in‑vivo assay data for this compound.

Name: Inhibition of the Burkholderia mallei acyl-homoserine lactone synthase BmaI1
Source: ICCB-Longwood/NSRB Screening Facility, Harvard Medical School
Target: autoinducer synthetase family protein [Burkholderia mallei ATCC 23344]
External Id: HMS1126

Name: Primary cell-based high-throughput screening assay for identification of compounds th...
Source: Johns Hopkins Ion Channel Center
Target: regulator of G-protein signaling 4 isoform 2 [Homo sapiens]
External Id: JHICC_RGS_Act_HTS

Name: Fluorescence-based counterscreen for orexin 1 receptor (OX1R) antagonists: cell-based...
Source: The Scripps Research Institute Molecular Screening Center
Target: N/A
External Id: CHOK1_ANT_FLUO8_1536_1X%INH CSRUN

Name: Absorbance-based primary biochemical high throughput screening assay to identify acti...
Source: The Scripps Research Institute Molecular Screening Center
Target: caspase-3 preproprotein [Homo sapiens]
External Id: PROCASPASE3_ACT_EPIABS_1536_1X%ACT PRUN

Name: Chemical Probes of Kaposi's Sarcoma Herpes Virus Latent Infection
Source: ICCB-Longwood/NSRB Screening Facility, Harvard Medical School
Target: ORF 73 [Human herpesvirus 8 type M]
External Id: HMS791

Name: Antibacterial activity against Staphylococcus aureus MRSA ATCC 43300 (CO-ADD:GP_020);...
Source: ChEMBL
Target: Staphylococcus aureus
External Id: CHEMBL4296184

Name: Antibacterial activity against Klebsiella pneumoniae MDR ATCC 70063 (CO-ADD:GN_003); ...
Source: ChEMBL
Target: Klebsiella pneumoniae
External Id: CHEMBL4296186

Name: Primary cell-based high-throughput screening for identification of compounds that all...
Source: Johns Hopkins Ion Channel Center
Target: MAS-related GPR member X1 [Homo sapiens]
External Id: JHICC_MrgX1_AlloAgonist_Primary

Name: Antibacterial activity against Escherichia coli ATCC 25922 (CO-ADD:GN_001); MIC in CA...
Source: ChEMBL
Target: Escherichia coli
External Id: CHEMBL4296185

Name: A screen for compounds that inhibit the activity of LtaS in Staphylococcus aureus
Source: ICCB-Longwood/NSRB Screening Facility, Harvard Medical School
External Id: HMS979

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This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.

Estra-1(10),2,4-trien-17-one, 3-(sulfooxy)-, sodium salt (1:1)

Sodium 17-oxoestra-1(10),2,4-trien-3-yl sulfate

Estrone 3-sulfate sodium salt

Estrone sodium sulfate

Estrone sulfate sodium

Estrone-3-sulfate sodium salt

estrone sodium sulphate

Sodium estrone 3-sulfate

This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.

Q: What are the upstream materials of estrone sodium sulfate?

A: Related upstream materials(CAS) of estrone sodium sulfate: 878408-57-2;53-16-7.

Q: What English synonyms does estrone sodium sulfate have?

A: English synonyms of estrone sodium sulfate: Estra-1(10),2,4-trien-17-one, 3-(sulfooxy)-, sodium salt (1:1), Sodium 17-oxoestra-1(10),2,4-trien-3-yl sulfate, Estrone 3-sulfate sodium salt, Estrone sodium sulfate, Estrone sulfate sodium, Estrone-3-sulfate sodium salt, estrone sodium sulphate, Sodium estrone 3-sulfate.

Q: What is the CAS number of estrone sodium sulfate?

A: CAS number of estrone sodium sulfate is 438-67-5.

Q: What is the polar surface area (PSA) of estrone sodium sulfate?

A: Polar surface area (PSA) of estrone sodium sulfate is 91.88000.

Q: What is the SMILES notation of estrone sodium sulfate?

A: SMILES notation of estrone sodium sulfate is CC12CCC3c4ccc(OS(=O)(=O)[O-])cc4CCC3C1CCC2=O.[Na+].

Q: What is the English name of estrone sodium sulfate?

A: The English name of estrone sodium sulfate is estrone sodium sulfate.

Q: What is the molecular weight of estrone sodium sulfate?

A: Molecular weight of estrone sodium sulfate is 372.41.

Q: What are the storage conditions for estrone sodium sulfate?

A: Storage conditions for estrone sodium sulfate: -20°C.

Q: What is the LogP of estrone sodium sulfate?

A: LogP of estrone sodium sulfate is 4.03160.

Q: What are the uses of estrone sodium sulfate?

A: Main uses of estrone sodium sulfate: Estrone sulfate, a biologically inactive form of estrogen, is a major circulating plasma estrogen that is converted into the biologically active estrogen, estrone (E1) by steroid sulfatase (STS). strone sulfate can be used for the research of breast cancer[1][2].

This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.

Shanghai Nianxing Industrial Co., Ltd

Dayang Chem (Hangzhou) Co., Ltd.

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Estrone sulfate sodium
Price: Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Estra-1,3,5(10)-trien-17-one,3-(sulfooxy)-, sodium salt (1:1)
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

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