80226-00-2
80226-00-2 structure
- Name: Enterodiol
- Chemical Name: (2R,3R)-2,3-bis[(3-hydroxyphenyl)methyl]butane-1,4-diol
- CAS Number: 80226-00-2
- Molecular Formula: C18H22O4
- Molecular Weight: 302.36
- Catalog: Biochemical Chinese herbal medicine ingredients
- Create Date: 2016-05-07 22:16:54
- Modify Date: 2024-01-02 15:10:13
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Enterodiol is transformed by human intestinal bacteria from lignans contained in various whole-grain cereals, nuts, legumes, flaxseed, and vegetables. Enterodiol has an apoptotic effect in colorectal cancer (CRC) cells. Anti-cancer activities[1][2].
| Name | (2R,3R)-2,3-bis[(3-hydroxyphenyl)methyl]butane-1,4-diol |
|---|---|
| Synonyms |
3,3'-[2,3-Bis(hydroxymethyl)butane-1,4-diyl]diphenol
Enterodiol Arbo 9 |
| Description | Enterodiol is transformed by human intestinal bacteria from lignans contained in various whole-grain cereals, nuts, legumes, flaxseed, and vegetables. Enterodiol has an apoptotic effect in colorectal cancer (CRC) cells. Anti-cancer activities[1][2]. |
|---|---|
| Related Catalog | |
| Target |
Human Endogenous Metabolite |
| In Vitro | Enterodiol (0-100 μM; 24-72 hours) results in an apoptosis rate of up to 40% in CT26 cells. Enterodiol shows no cytotoxicity toward RAW264.7 macrophages[1]. Enterodiol (0-100 μM; 24-48 hours) also suppresses the migration of CRC cells in a concentration-dependent manner. The phosphorylation of ERK, JNK, and p38 is down-regulated with Enterodiol treatment. Enterodiol (0-100 μM; 48 hours) decreases the expression levels of anti-apoptotic proteins in CRC cells[1]. |
| In Vivo | Enterodiol (1 mg/kg; intra-tumor injection method; once every other day until day 32) suppresses tumor markedly[2]. Animal Model: 4-8 weeks old female BALB/c nude mice[2] Dosage: 1 mg/kg Administration: Intra-tumor injection method; once every other day until day 32 Result: A significant reduction in the tumor volume in the experimental groups compared to the PBS group. |
| References |
| Density | 1.251g/cm3 |
|---|---|
| Boiling Point | 554.9ºC at 760 mmHg |
| Molecular Formula | C18H22O4 |
| Molecular Weight | 302.36 |
| Flash Point | 262.5ºC |
| Exact Mass | 302.15200 |
| PSA | 80.92000 |
| LogP | 2.10000 |
| Index of Refraction | 1.626 |
| Storage condition | 2-8°C |
| Hazard Codes | Xi: Irritant; |
|---|---|
| Risk Phrases | R36/37/38 |
| Safety Phrases | 26-36 |
| WGK Germany | 3 |