Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Formamide,N-[(1E)-2-(2,5-dihydroxyphenyl)ethenyl]-
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100827-28-9

100827-28-9 structure

100827-28-9 structure

Name: Formamide,N-[(1E)-2-(2,5-dihydroxyphenyl)ethenyl]-
Chemical Name: N-[(E)-2-(2,5-dihydroxyphenyl)ethenyl]formamide
CAS Number: 100827-28-9
Molecular Formula: C₉H₉NO₃
Molecular Weight: 179.17
Create Date: 2017-06-13 03:35:06
Modify Date: 2024-01-09 09:51:32
Erbstatin, a EGFR kinase inhibitor, possesses antineoplastic effect[1][2].

Name	N-[(E)-2-(2,5-dihydroxyphenyl)ethenyl]formamide
Synonyms	N-[2-(2,5-dihydroxyphenyl)ethenyl]formamide FORMAMIDE,N-(2-(2,5-DIHYDROXYPHENYL)ETHENYL)-,(E) (E)-N-(2-(2,5-Dihydroxyphenyl)ethenyl)formamide (2-formamidovinyl)-2,5-dihydroxybenzene Erbstatin

Description	Erbstatin, a EGFR kinase inhibitor, possesses antineoplastic effect[1][2].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> JAK/STAT Signaling >> EGFR Signaling Pathways >> Protein Tyrosine Kinase/RTK >> EGFR
In Vitro	Erbstatin不抑制EGF与其受体的结合，但是会抑制EGFR复合物的内吞作用，而且该化合物不会抑制A431细胞中EGF刺激的磷脂酰肌醇代谢[2]。 Erbstatin引起人小细胞肺癌（SCLC）细胞形态学凋亡和DNA断裂[3]。
References	[1]. Shigeki Kobayashi, et al. Diastereomer-specific effects of double-stranded peptides conjugated with -L-Tyr-L-Phe- or -L-Tyr-D-Phe- residues on tyrosine phosphorylation and inhibition of src(ts)NRK, A431, MCF-7, and DU145 cell growth. Chem Pharm Bull (Tokyo). 2007 Nov;55(11):1585-92. [2]. M Toi, et al. Antineoplastic effect of erbstatin on human mammary and esophageal tumors in athymic nude mice. Eur J Cancer. 1990;26(6):722-4. [3]. S Simizu, et al. Involvement of hydrogen peroxide production in erbstatin-induced apoptosis in human small cell lung carcinoma cells. Cancer Res. 1996 Nov 1;56(21):4978-82.

Density	1.343g/cm3
Boiling Point	517.5ºC at 760mmHg
Molecular Formula	C₉H₉NO₃
Molecular Weight	179.17
Flash Point	266.8ºC
Exact Mass	179.05800
PSA	69.56000
LogP	1.84130
Vapour Pressure	2.48E-11mmHg at 25°C
Index of Refraction	1.667

CHEMICAL IDENTIFICATION

RTECS NUMBER :: KD9500000

CHEMICAL NAME :: Formamide, N-(2-(2,5-dihydroxyphenyl)ethenyl)-, (E)-

CAS REGISTRY NUMBER :: 100827-28-9

LAST UPDATED :: 199109

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C9-H9-N-O3

MOLECULAR WEIGHT :: 179.19

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: Mutation test systems - not otherwise specified

TEST SYSTEM :: Rodent - mouse Leukocyte

DOSE/DURATION :: 15 mg/L

REFERENCE :: JJCREP Japanese Journal of Cancer Research. (Elsevier Science Pub. BV, POB 211, 1000 AE Amsterdam, Netherlands) V.76- 1985- Volume(issue)/page/year: 78,329,1987

Precursor 9
108536-21-6 113093-47-3 2688-48-4 93-02-7
108536-18-1 38489-67-7 33567-62-3 13391-35-0
584-82-7
DownStream 0