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37795-69-0

37795-69-0 structure
37795-69-0 structure
  • Name: W-2429
  • Chemical Name: 2,3-dihydro-[1,2]oxazolo[3,2-b]quinazolin-9-one
  • CAS Number: 37795-69-0
  • Molecular Formula: C10H8N2O2
  • Molecular Weight: 188.18300
  • Catalog: Research Areas Neurological Disease
  • Create Date: 2017-10-22 18:26:38
  • Modify Date: 2024-02-04 22:29:38
  • W-2429 is a non-narcotic analgesic agent.
Name 2,3-dihydro-[1,2]oxazolo[3,2-b]quinazolin-9-one
Synonyms W 2429
2,3-dihydro-9H-isoxazolo<3,2-b>quinazolin-9-one
W-2429
Description W-2429 is a non-narcotic analgesic agent.
Related Catalog
In Vivo W-2429 is a non-narcotic analgesic agent. Treatment with W-2429 is well tolerated by rats as well as dogs. In the dog, the only signs of toxicity observed are decreased appetite and salivation at 100 mg/kg/day W-2429. No other significant evidence of physical, chemical, gross or histopathologic change is observed[1].
References

[1]. Banerjee BN, et al. Toxicological investigation of 2,3-dihydro-9H-isoxazolo[3,2-b]quinazolin-9-one (W-2429). Acuteand subacute toxicity in mice, rats and dogs. Arzneimittelforschung. 1977;27(4):793-801.

Density 1.47g/cm3
Boiling Point 330ºC at 760mmHg
Molecular Formula C10H8N2O2
Molecular Weight 188.18300
Flash Point 153.4ºC
Exact Mass 188.05900
PSA 44.12000
LogP 0.38120
Index of Refraction 1.719
Storage condition 2-8℃

CHEMICAL IDENTIFICATION

RTECS NUMBER :
NY3450000
CHEMICAL NAME :
9H-Isoxazolo(3,2-b)quinazolin-9-one, 2,3-dihydro-
CAS REGISTRY NUMBER :
37795-69-0
LAST UPDATED :
199706
DATA ITEMS CITED :
7
MOLECULAR FORMULA :
C10-H8-N2-O2
MOLECULAR WEIGHT :
188.20

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
395 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - ataxia Behavioral - convulsions or effect on seizure threshold
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 27,770,1977
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
278 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - ataxia Behavioral - convulsions or effect on seizure threshold
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 27,770,1977
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
420 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - ataxia Behavioral - convulsions or effect on seizure threshold
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 27,770,1977
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
212 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - ataxia Behavioral - convulsions or effect on seizure threshold
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 27,770,1977
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
700 mg/kg
TOXIC EFFECTS :
Behavioral - food intake (animal) Gastrointestinal - changes in structure or function of salivary glands
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 27,793,1977 ** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
3 gm/kg/30D-C
TOXIC EFFECTS :
Brain and Coverings - changes in brain weight Liver - changes in liver weight Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 27,793,1977
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
3 gm/kg/30D-I
TOXIC EFFECTS :
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 27,793,1977
HS Code 2934999090
37795-76-9 structure

37795-76-9

~%

37795-69-0 structure

37795-69-0

Literature: Reisner; Ludwig; Simon; Dejneka; Sofia Arzneimittel-Forschung/Drug Research, 1977 , vol. 27, # 4 p. 766 - 770
134-20-3 structure

134-20-3

~%

37795-69-0 structure

37795-69-0

Literature: Reisner; Ludwig; Simon; Dejneka; Sofia Arzneimittel-Forschung/Drug Research, 1977 , vol. 27, # 4 p. 766 - 770
118-48-9 structure

118-48-9

625-36-5 structure

625-36-5

~%

37795-69-0 structure

37795-69-0

Literature: Dunn, A. D.; Kinnear, K. I.; Norrie, R.; Ringan, N.; Martin, D. Journal of Heterocyclic Chemistry, 1987 , vol. 24, p. 175 - 180
1192-07-0 structure

1192-07-0

118-48-9 structure

118-48-9

~%

37795-69-0 structure

37795-69-0

Literature: Reisner; Ludwig; Simon; Dejneka; Sofia Arzneimittel-Forschung/Drug Research, 1977 , vol. 27, # 4 p. 766 - 770
HS Code 2934999090
Summary 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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