上海化源世纪贸易有限公司
上海市上海市普陀区
产品名：W-2429
纯度：98.7%
规格：
联系人：徐经理
联系电话：13311869306

上海创赛科技有限公司
上海市上海市嘉定区
产品名：[Perfemiker]W-2429,98%
纯度：98.0%
规格：5mg/1mg
联系人：夏言
联系电话：18016376636

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37795-69-0生产厂家

37795-69-0价格

37795-69-0

37795-69-0结构式

常用中文名：W-2429
常用英文名：W-2429
CAS号：37795-69-0
分子式：C₁₀H₈N₂O₂
分子量：188.18300
相关类别：研究领域神经疾病
发布时间：2017-10-22 18:26:38
更新时间：2024-02-04 22:29:38
W-2429 是一种非麻醉性镇痛药。

化源商城直购

中文名	W-2429
英文名	2,3-dihydro-[1,2]oxazolo[3,2-b]quinazolin-9-one
英文别名	W 2429 2,3-dihydro-9H-isoxazolo<3,2-b>quinazolin-9-one W-2429

描述	W-2429 是一种非麻醉性镇痛药。
相关类别	信号通路 >> 其他 >> 其他研究领域 >> 神经疾病
体内研究	W-2429是一种非麻醉性镇痛剂。大鼠以及狗对W-2429的治疗耐受良好。在狗中,观察到的唯一毒性迹象是在100mg/kg /天W-2429下食欲和流涎减少。没有观察到其他物理,化学,严重或组织病理学变化的重要证据[1]。
参考文献	[1]. Banerjee BN, et al. Toxicological investigation of 2,3-dihydro-9H-isoxazolo[3,2-b]quinazolin-9-one (W-2429). Acuteand subacute toxicity in mice, rats and dogs. Arzneimittelforschung. 1977;27(4):793-801.

密度	1.47g/cm3
沸点	330ºC at 760mmHg
分子式	C₁₀H₈N₂O₂
分子量	188.18300
闪点	153.4ºC
精确质量	188.05900
PSA	44.12000
LogP	0.38120
折射率	1.719
储存条件	2-8℃

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NY3450000

CHEMICAL NAME :: 9H-Isoxazolo(3,2-b)quinazolin-9-one, 2,3-dihydro-

CAS REGISTRY NUMBER :: 37795-69-0

LAST UPDATED :: 199706

DATA ITEMS CITED :: 7

MOLECULAR FORMULA :: C10-H8-N2-O2

MOLECULAR WEIGHT :: 188.20

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 395 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - ataxia Behavioral - convulsions or effect on seizure threshold

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 27,770,1977

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 278 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - ataxia Behavioral - convulsions or effect on seizure threshold

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 27,770,1977

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 420 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - ataxia Behavioral - convulsions or effect on seizure threshold

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 27,770,1977

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 212 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - ataxia Behavioral - convulsions or effect on seizure threshold

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 27,770,1977

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 700 mg/kg

TOXIC EFFECTS :: Behavioral - food intake (animal) Gastrointestinal - changes in structure or function of salivary glands

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 27,793,1977 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3 gm/kg/30D-C

TOXIC EFFECTS :: Brain and Coverings - changes in brain weight Liver - changes in liver weight Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 27,793,1977

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 3 gm/kg/30D-I

TOXIC EFFECTS :: Nutritional and Gross Metabolic - weight loss or decreased weight gain

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 27,793,1977

海关编码	2934999090

37795-76-9

37795-69-0

文献：Reisner; Ludwig; Simon; Dejneka; Sofia Arzneimittel-Forschung/Drug Research, 1977 , vol. 27, # 4 p. 766 - 770

134-20-3

37795-69-0

文献：Reisner; Ludwig; Simon; Dejneka; Sofia Arzneimittel-Forschung/Drug Research, 1977 , vol. 27, # 4 p. 766 - 770

118-48-9

625-36-5

37795-69-0

文献：Dunn, A. D.; Kinnear, K. I.; Norrie, R.; Ringan, N.; Martin, D. Journal of Heterocyclic Chemistry, 1987 , vol. 24, p. 175 - 180

1192-07-0

118-48-9

37795-69-0

文献：Reisner; Ludwig; Simon; Dejneka; Sofia Arzneimittel-Forschung/Drug Research, 1977 , vol. 27, # 4 p. 766 - 770

上游产品 5
37795-76-9 134-20-3 118-48-9 625-36-5
1192-07-0
下游产品 1
63480-08-0

海关编码	2934999090
中文概述	2934999090. 其他杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途
Summary	2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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