42749-27-9

42749-27-9 structure

Name: Bis-Tos-PEG6
Chemical Name: 2-[2-[2-[2-[2-[2-(4-methylphenyl)sulfonyloxyethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethyl 4-methylbenzenesulfonate
CAS Number: 42749-27-9
Molecular Formula: C₂₆H₃₈O₁₁S₂
Molecular Weight: 590.70300
Catalog: Signaling Pathways PROTAC PROTAC Linker
Create Date: 2017-08-24 20:26:14
Modify Date: 2024-01-08 01:54:20
Bis-Tos-PEG6 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name	2-[2-[2-[2-[2-[2-(4-methylphenyl)sulfonyloxyethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethyl 4-methylbenzenesulfonate
Synonyms	PEG7-bis-Tos Hexaethylene glycol ditosylate O,O'-ditosyl-3,6,9,12,15-pentaoxaheptadecane-1,17-diol 3,6,9,12,15-pentaoxaheptadecane-1,17-diol ditosylate HEG ditosylate 3,6,9,12,15-pentaoxa-1,17-heptadecyl di-p-toluenesulfonate

Description	Bis-Tos-PEG6 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker
Target	PEGs
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References	[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

RIDADR	NONH for all modes of transport
HS Code	2909499000

2615-15-8

98-59-9

~99%

42749-27-9

2615-15-8

98-59-9

~6%

42749-27-9

42749-28-0

Literature: Bouzide, Abderrahim; Sauve, Gilles Organic Letters, 2002 , vol. 4, # 14 p. 2329 - 2332

144270-96-2

42749-27-9

Literature: Chen, Yiyan; Baker, Gregory L. Journal of Organic Chemistry, 1999 , vol. 64, # 18 p. 6870 - 6873

96922-86-0

42749-27-9

Literature: Beadle, James R.; Dishong, Dennis M.; Khanna, Raj K.; Gokel, George W. Tetrahedron, 1984 , vol. 40, # 20 p. 3935 - 3944

2615-15-8

42749-27-9

Literature: Beadle, James R.; Dishong, Dennis M.; Khanna, Raj K.; Gokel, George W. Tetrahedron, 1984 , vol. 40, # 20 p. 3935 - 3944

HS Code	2909499000
Summary	2909499000. ether-alcohols and their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:5.5%. General tariff:30.0%