516493-93-9

516493-93-9 structure

Name: Azido-PEG5-amine
Chemical Name: 2-[2-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethanamine
CAS Number: 516493-93-9
Molecular Formula: C₁₂H₂₆N₄O₅
Molecular Weight: 306.35900
Catalog: Chemical reagent Organic reagent Azide
Create Date: 2018-08-04 00:16:48
Modify Date: 2024-01-02 08:52:20
Azido-PEG5-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name	2-[2-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethanamine
Synonyms	17-azido-3,6,9,12,15-pentaoxaheptadecanamine 5-PEG amino azide 17-azido-3,6,9,12,15-pentaoxa-1-heptadecylamine 17-azide-3,6,9,12,15-pentaoxaheptadecan-1-amine Azido-PEG5-Amine 17-AZIDO-3,6,9,12,15-PENTAOXAHEPTADECAN-1-AMINE 1-amino-17-azido-3,6,9,12,15-pentaoxaheptadecane

Description	Azido-PEG5-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker
Target	PEGs
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References	[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562