620-61-1

620-61-1 structure

Name: Hyoscyamine sulfate hydrate
Chemical Name: l-hyoscyamine hemisulfate salt
CAS Number: 620-61-1
Molecular Formula: C₁₇H₂₄NO₅S_0.5
Molecular Weight: 676.817
Catalog: Natural product Alkaloid
Create Date: 2018-04-13 08:00:00
Modify Date: 2024-01-07 18:15:21
L-Hyoscyamine sulfate (Daturine sulfate) is a tropane alkaloid that is a secondary metabolite found in certain plants of the solanaceae family. In vitro it has been shown to be an antagonist of mAChR[1].

Name	l-hyoscyamine hemisulfate salt
Synonyms	Benzeneacetic acid, α-(hydroxymethyl)-, (3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester, sulfate, hydrate (2:1:1) (salt) Atropina Solfato UNII:03J5ZE7KA5 L-TROPINE TROPATE SULFATE atropine sulphate L-Hyoscyamine Hemisulfate atropin sulfate Benzeneacetic acid, α-(hydroxymethyl)-, (3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester, (αS)-, sulfate (2:1) (salt) (3-endo)-8-Methyl-8-azabicyclo[3.2.1]oct-3-yl 3-hydroxy-2-phenylpropanoate sulfate hydrate (2:1:1) Atropine Sulfate Monohydrate MFCD00078244 (3-endo)-8-Methyl-8-azabicyclo[3.2.1]oct-3-yl 3-hydroxy-2-phenylpropanoate sulfate (2:1) hydrate (salt) levsinsulfate EINECS 210-644-6 Atropinsulfat (3-endo)-8-Methyl-8-azabicyclo[3.2.1]oct-3-yl (2S)-3-hydroxy-2-phenylpropanoate sulfate (2:1) L-HYOSCYAMINE SULFATE Hyoscyamine sulfate hydrate

Description	L-Hyoscyamine sulfate (Daturine sulfate) is a tropane alkaloid that is a secondary metabolite found in certain plants of the solanaceae family. In vitro it has been shown to be an antagonist of mAChR[1].
Related Catalog	Signaling Pathways >> Neuronal Signaling >> mAChR Signaling Pathways >> GPCR/G Protein >> mAChR Research Areas >> Neurological Disease
References	[1]. Jones JB, et al. Sublingual hyoscyamine sulfate in combination with ketorolac tromethamine for ureteral colic: a randomized, double-blind, controlled trial. Ann Emerg Med. 2001 Feb;37(2):141-6.

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation) Cardiac - pulse rate increase, without fall in BP Skin and Appendages - dermatitis, other (after systemic exposure)

REFERENCE :: AJEMEN American Journal of Emergency Medicine. (WB Saunders, Philadelphia, PA) V.1- 1983- Volume(issue)/page/year: 15,532,1997

TOXIC EFFECTS :: Behavioral - irritability Cardiac - pulse rate increase, without fall in BP Skin and Appendages - dermatitis, other (after systemic exposure)

REFERENCE :: AJEMEN American Journal of Emergency Medicine. (WB Saunders, Philadelphia, PA) V.1- 1983- Volume(issue)/page/year: 15,532,1997

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Cardiac - pulse rate increase, without fall in BP Skin and Appendages - dermatitis, other (after systemic exposure)

REFERENCE :: AJEMEN American Journal of Emergency Medicine. (WB Saunders, Philadelphia, PA) V.1- 1983- Volume(issue)/page/year: 15,532,1997

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961- Volume(issue)/page/year: 55,849,1966 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 80431 No. of Facilities: 967 (estimated) No. of Industries: 3 No. of Occupations: 9 No. of Employees: 3990 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 80431 No. of Facilities: 445 (estimated) No. of Industries: 1 No. of Occupations: 5 No. of Employees: 14970 (estimated) No. of Female Employees: 12609 (estimated)