211555-04-3
211555-04-3 structure
- Name: WHI-P154
- Chemical Name: 2-bromo-4-[(6,7-dimethoxyquinazolin-4-yl)amino]phenol
- CAS Number: 211555-04-3
- Molecular Formula: C16H14BrN3O3
- Molecular Weight: 376.205
- Catalog: Biochemical Inhibitor Tyrosine protein kinase/signal transducer and transcriptional activator inhibitor (JAK/STAT) JAK inhibitor
- Create Date: 2018-10-09 11:39:33
- Modify Date: 2024-01-05 18:54:56
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WHI-P154 is a potent EGFR inhibitor, and also modestly blocks JAK3, with IC50s of 4 nM and 1.8 μM, respectively.
| Name | 2-bromo-4-[(6,7-dimethoxyquinazolin-4-yl)amino]phenol |
|---|---|
| Synonyms |
2-Bromo-4-[(6,7-dimethoxyquinazolin-4-yl)amino]phenol
2-Bromo-4-[(6,7-dimethoxy-4-quinazolinyl)amino]phenol Phenol, 2-bromo-4-[(6,7-dimethoxy-4-quinazolinyl)amino]- WHI-P154 jak3 inhibitor ii 2-Bromo-4-[(6,7-dimethoxy-4-quinazolinyl)amino]-phenol |
| Description | WHI-P154 is a potent EGFR inhibitor, and also modestly blocks JAK3, with IC50s of 4 nM and 1.8 μM, respectively. |
|---|---|
| Related Catalog | |
| Target |
EGFR:4 nM (IC50) JAK3:1.8 μM (IC50) |
| In Vitro | WHI-P154 is a potent EGFR inhibitor, and also modestly blocks JAK3, with IC50s of 4 nM and 1.8 μM, respectively[1]. WHI-P154 significantly enhances the sensitivity of ABCG2-overexpressing cells to its substrates. WHI-P154 (4 μM) moderately sensitizes ABCB1-overexpressing KB-C2 cells to its substrates whereas shows no sensitizing effect on ABCC1-, ABCC2 or ABCC10-mediated drug resistance. Moreover, WHI-P154 (4 μM) causes a significant increase in the intracellular accumulation of [3H]-mitoxantrone in ABCG2-overexpressing cells. WHI-P154 alters the expression levels rather than the localization of the ABCG2 protein in ABCG2-overexpressing cells[2]. |
| References |
| Density | 1.6±0.1 g/cm3 |
|---|---|
| Boiling Point | 470.3±45.0 °C at 760 mmHg |
| Melting Point | 230 °C |
| Molecular Formula | C16H14BrN3O3 |
| Molecular Weight | 376.205 |
| Flash Point | 238.2±28.7 °C |
| Exact Mass | 375.021851 |
| PSA | 76.50000 |
| LogP | 4.15 |
| Appearance | white to brown |
| Vapour Pressure | 0.0±1.2 mmHg at 25°C |
| Index of Refraction | 1.703 |
| Storage condition | Store at RT |
| Water Solubility | DMSO: soluble1mg/mL, clear (warmed) |
| Symbol |
GHS06 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H301-H315-H319-H335 |
| Precautionary Statements | P261-P301 + P310-P305 + P351 + P338 |
| Hazard Codes | Xn |
| Risk Phrases | 22-36/37/38 |
| Safety Phrases | 26 |
| RIDADR | UN 2811 6.1 / PGIII |