51146-57-7
51146-57-7 structure
- Name: (R)-(-)-Ibuprofen
- Chemical Name: levibuprofen
- CAS Number: 51146-57-7
- Molecular Formula: C13H18O2
- Molecular Weight: 206.281
- Catalog: Research Areas Inflammation/Immunology
- Create Date: 2018-05-30 08:00:00
- Modify Date: 2026-07-04 19:45:09
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(R)-(-)-Ibuprofen is the R enantiomer of Ibuprofen, inactive on COX, inhibits NF-κB activation; (R)-(-)-Ibuprofen exhibits anti-inflammatory and antinociceptive effects.
| Name | levibuprofen |
|---|---|
| Synonyms |
(R)-(-)-IBUPROFEN
(R)-IBUPROFEN Ibumetin (R)-(-)-Ibuprofen, 10 mM in DMSO QVY1&R D1Y1&1 (-)-Ibuprofen l-Ibuprofen (R)-IbuprofenQ: What is (R)-Ibuprofen Q: What is the CAS Number of (R)-Ibuprofen Q: What is the storage condition of (R)-Ibuprofen Q: What e the applications of (R)-Ibuprofen (R)-(-)-2-(4-ISOBUTYLPHENYL)-PROPIONIC ACID Ibuprofen Ibuprofen (R)-Isomer (±)-ibuprofen Novogent N Ibutid 2-(4-Isobutylphenyl)propanoic acid MOTRIN Dolgirid (alph-alpha-Methyl-4-(2-methylpropyl)benzeneacetic acid Amibufen R-(-)-p-Isobutylhydratropic acid (-)-ibuprofen (R)-(-)-ibuprofen reference substance (αR)-α-Methyl-4-(2-methylpropyl)-benzeneacetic Acid Racemic ibuprofen (2R)-2-[4-(2-methylpropyl)phenyl]propanoic acid (2R)-2-(4-isobutylphenyl)propanoic acid Advil (R)-(-)-Ibuprofen ((R)-Ibuprofen) Dolo-Dolgit UNII:WK2XYI10QM IbU Benzeneacetic acid, a-Methyl-4-(2-Methylpropyl) Panafen Inoven Lebrufen (RS)-ibuprofen Femadon 2-(4-Isobutylphenyl)propionic acid Para-Isobutylhydratropic Acid (2R)-2-(4-Isobutylphenyl)propanoic acid (R)-2-(4-Isobutylphenyl)propanoic acid (R)-(-)-Ibupr en fenbid (R)-Ibuprofen 2-Yl)cbamate Nurofen Benzeneacetic acid, α-methyl-4-(2-methylpropyl)-, (R) (-)-Ibuprophen (R)-(-)-IBUPROFEN //BP 5-Triiodo-L-thyronine sodium Brufen Benzeneacetic acid, α-methyl-4-(2-methylpropyl)-, (αR) Seclodin a-Methyl-4-(2-methylpropyl)benzeneacetic Acid Ibuprofen Impurity 20((R)-Isomer) |
| Description | (R)-(-)-Ibuprofen is the R enantiomer of Ibuprofen, inactive on COX, inhibits NF-κB activation; (R)-(-)-Ibuprofen exhibits anti-inflammatory and antinociceptive effects. |
|---|---|
| Related Catalog | |
| Target |
NF-κB |
| In Vitro | (R)-(-)-Ibuprofen is the R enantiomer of Ibuprofen, with no inhibitory effect on COX, but is involved in pathways of lipid metabolism and is incorporated into triglycerides along with endogenous fatty acids[1]. (R)-(-)-Ibuprofen (1 μM) significantly reduces NF-κB activation and completely prevents NF-κB induction at 10 μM. (R)-(-)-Ibuprofen inhibits NF-κB luciferase activity with an IC50 of 121.8 μM, weaker than that of S(+)-ibuprofen (IC50, 61.7 μM). Furthermore, (R)-(-)-Ibuprofen (10 mM) has no effect on HSF[2]. |
| References |
| Density | 1.0±0.1 g/cm3 |
|---|---|
| Boiling Point | 319.6±11.0 °C at 760 mmHg |
| Melting Point | 41-42ºC |
| Molecular Formula | C13H18O2 |
| Molecular Weight | 206.281 |
| Flash Point | 216.7±14.4 °C |
| Exact Mass | 206.130676 |
| PSA | 37.30000 |
| LogP | 3.72 |
| Vapour Pressure | 0.0±0.7 mmHg at 25°C |
| Index of Refraction | 1.519 |
| HS Code | 2916399090 |
|---|
| Precursor 9 | |
|---|---|
| DownStream 1 | |
![N-[3-[(3-propoxybenzoyl)carbamothioylamino]phenyl]furan-2-carboxamide structure](https://image.chemsrc.com/caspic/447/6448-14-2.png)
| HS Code | 2916399090 |
|---|---|
| Summary | 2916399090 other aromatic monocarboxylic acids, their anhydrides, halides, peroxides, peroxyacids and their derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0% |