(R)-(-)-Ibuprofen
(R)-(-)-Ibuprofen structure
|
Common Name | (R)-(-)-Ibuprofen | ||
|---|---|---|---|---|
| CAS Number | 51146-57-7 | Molecular Weight | 206.281 | |
| Density | 1.0±0.1 g/cm3 | Boiling Point | 319.6±11.0 °C at 760 mmHg | |
| Molecular Formula | C13H18O2 | Melting Point | 41-42ºC | |
| MSDS | N/A | Flash Point | 216.7±14.4 °C | |
Use of (R)-(-)-Ibuprofen(R)-(-)-Ibuprofen is the R enantiomer of Ibuprofen, inactive on COX, inhibits NF-κB activation; (R)-(-)-Ibuprofen exhibits anti-inflammatory and antinociceptive effects. |
This table lists Chinese names, IUPAC names and various aliases of this chemical substance.
| Name | levibuprofen |
|---|---|
| Synonym | More Synonyms |
This table contains bioactivity, target information and biological‑assay experimental data of this compound.
| Description | (R)-(-)-Ibuprofen is the R enantiomer of Ibuprofen, inactive on COX, inhibits NF-κB activation; (R)-(-)-Ibuprofen exhibits anti-inflammatory and antinociceptive effects. |
|---|---|
| Related Catalog | |
| Target |
NF-κB |
| In Vitro | (R)-(-)-Ibuprofen is the R enantiomer of Ibuprofen, with no inhibitory effect on COX, but is involved in pathways of lipid metabolism and is incorporated into triglycerides along with endogenous fatty acids[1]. (R)-(-)-Ibuprofen (1 μM) significantly reduces NF-κB activation and completely prevents NF-κB induction at 10 μM. (R)-(-)-Ibuprofen inhibits NF-κB luciferase activity with an IC50 of 121.8 μM, weaker than that of S(+)-ibuprofen (IC50, 61.7 μM). Furthermore, (R)-(-)-Ibuprofen (10 mM) has no effect on HSF[2]. |
| References |
This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.
| Density | 1.0±0.1 g/cm3 |
|---|---|
| Boiling Point | 319.6±11.0 °C at 760 mmHg |
| Melting Point | 41-42ºC |
| Molecular Formula | C13H18O2 |
| Molecular Weight | 206.281 |
| Flash Point | 216.7±14.4 °C |
| Exact Mass | 206.130676 |
| PSA | 37.30000 |
| LogP | 3.72 |
| Vapour Pressure | 0.0±0.7 mmHg at 25°C |
| Index of Refraction | 1.519 |
| InChIKey | HEFNNWSXXWATRW-SNVBAGLBSA-N |
| SMILES | CC(C)Cc1ccc(C(C)C(=O)O)cc1 |
This table provides MSDS information including hazard classification, first‑aid, fire‑fighting, spill handling, operation and storage instructions.
This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.
| HS Code | 2916399090 |
|---|
This table presents publicly reported synthetic routes, reaction conditions, reactants and product information of the compound.
This table lists upstream starting materials and downstream derivative products related to this chemical.
| Precursor 9 | |
|---|---|
| DownStream 1 | |
![N-[3-[(3-propoxybenzoyl)carbamothioylamino]phenyl]furan-2-carboxamide Structure](https://image.chemsrc.com/caspic/447/6448-14-2.png)
CAS#:6448-14-2
CAS#:15687-27-1
CAS#:62784-66-1
CAS#:110282-71-8
CAS#:1187670-13-8
CAS#:51407-46-6
CAS#:61566-34-5
CAS#:298197-67-8
CAS#:2039-82-9
CAS#:34352-86-8This table shows customs‑related data including HS‑code, tariff and regulatory conditions for import and export.
| HS Code | 2916399090 |
|---|---|
| Summary | 2916399090 other aromatic monocarboxylic acids, their anhydrides, halides, peroxides, peroxyacids and their derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0% |
This table contains target information, in‑vitro & in‑vivo assay data for this compound.
This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.
| Inoven |
| Lebrufen |
| (RS)-ibuprofen |
| Ibumetin |
| Femadon |
| 2-(4-Isobutylphenyl)propionic acid |
| QVY1&R D1Y1&1 |
| l-Ibuprofen |
| Para-Isobutylhydratropic Acid |
| Ibuprofen |
| (2R)-2-(4-Isobutylphenyl)propanoic acid |
| (R)-2-(4-Isobutylphenyl)propanoic acid |
| (±)-ibuprofen |
| Novogent N |
| Ibutid |
| fenbid |
| 2-(4-Isobutylphenyl)propanoic acid |
| MOTRIN |
| Dolgirid |
| (R)-Ibuprofen |
| Amibufen |
| (-)-ibuprofen |
| Nurofen |
| (R)-(-)-Ibuprofen |
| Racemic ibuprofen |
| (2R)-2-[4-(2-methylpropyl)phenyl]propanoic acid |
| Advil |
| Brufen |
| Dolo-Dolgit |
| Seclodin |
| UNII:WK2XYI10QM |
| IbU |
| Panafen |
This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.
| Q: What is the InChIKey of levibuprofen? |
| A: InChIKey of levibuprofen is HEFNNWSXXWATRW-SNVBAGLBSA-N. |
| Q: What is the molecular weight of levibuprofen? |
| A: Molecular weight of levibuprofen is 206.281. |
| Q: What is the LogP of levibuprofen? |
| A: LogP of levibuprofen is 3.72. |
| Q: What is the SMILES notation of levibuprofen? |
| A: SMILES notation of levibuprofen is CC(C)Cc1ccc(C(C)C(=O)O)cc1. |
| Q: What is the melting point of levibuprofen? |
| A: Melting point of levibuprofen is 41-42ºC. |
| Q: What are the uses of levibuprofen? |
| A: Main uses of levibuprofen: (R)-(-)-Ibuprofen is the R enantiomer of Ibuprofen, inactive on COX, inhibits NF-κB activation; (R)-(-)-Ibuprofen exhibits anti-inflammatory and antinociceptive effects. |
| Q: What is the CAS number of levibuprofen? |
| A: CAS number of levibuprofen is 51146-57-7. |
| Q: What are the upstream materials of levibuprofen? |
| A: Related upstream materials(CAS) of levibuprofen: 6448-14-2;15687-27-1;62784-66-1;110282-71-8;1187670-13-8;51407-46-6;61566-34-5;298197-67-8;2039-82-9. |
| Q: What is the boiling point of levibuprofen? |
| A: Boiling point of levibuprofen is 319.6±11.0 °C at 760 mmHg. |
| Q: What is the polar surface area (PSA) of levibuprofen? |
| A: Polar surface area (PSA) of levibuprofen is 37.30000. |
This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.
| Shanghai Nianxing Industrial Co., Ltd |
| Dayang Chem (Hangzhou) Co., Ltd. |
| Henan Tianfu Chemical Co., Ltd. |